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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b, kappa|
|Storage buffer||PBS with 0.1% gelatin|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.
c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dominant white spotting, SCFR, Steel Factor Receptor, belly-spot, c-kit proto-oncogene protein, dominant spotting, mast/stem cell growth factor receptor Kit, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, spotted sterile male, tyrosine-protein kinase Kit, C-Kit, CD117, PBT, piebald trait protein, soluble KIT variant 1, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit
Fdc, c-KIT, Gsfsco1, Ssm, SCO5, Bs, SCO1, Tr-kit, W, CD117, Gsfsow3, Gsfsco5, SOW3
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Immunity and defense Stress response Oncogenesis Developmental processes Gametogenesis Embryogenesis Cell structure and motility Cell motility Cell proliferation and differentiation