Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
Staining of normal human peripheral blood cells with the Human Hematopoietic Lineage APC Cocktail, Anti-Human CD34 FITC and Mouse IgG1 K Isotype Control PE-Cy7 (left) or Anti-Human CD117 (c-kit) PE-Cy7 (right, cat. no. A14779). Lineage negative/low cells were used for analysis.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||MOLM-1 megakaryocytic cells|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PBT, C-Kit, SCFR, CD117
mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, C-Kit, CD117, PBT, SCFR