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Product Details
651152
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
J19
Immunogen
Synthetic Peptide J6 (Corresponding To Aa 292-309), Coupled To Klh
Conjugate
Unconjugated
Form
Liquid
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Specific Information
Recognizes neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin/armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Delta-catenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimer's disease. No cross-reaction with other members of the armadillo/plakoglobin protein family. Polypeptide reacting: Neurojungin (delta-catenin), 160 kD polypeptide; in endothelia from blood vessels the antibody is positive with a 300 kD polypeptide.Reactivity on cultured cell lines: Murine cell line A1B2, A431 stably transfected with neurojungin cDNA. Positive control: Murine brain, retina.
Target Information
Delta 1 Catenin is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin-associated Src substrate; Cadherin-associated Src substrate (CAS); CAS; Catenin (cadherin associated protein) delta 1; catenin (cadherin-associated protein), delta 1; Catenin delta-1; catenin src; catenin, delta 1; p120 catenin; P120 CTN; P120 p120; P120 P120CTN; p120(cas); p120(ctn); p120-catenin
Gene Aliases: AA409437; AU019353; CAS; Catns; CTNND; CTNND1; KIAA0384; mKIAA0384; P120; p120(CAS); p120(CTN); P120CAS; P120CTN
UniProt ID: (Human) O60716, (Mouse) P30999
Entrez Gene ID: (Bovine) 515187, (Human) 1500, (Mouse) 12388, (Rat) 311163, (Zebrafish) 556726
Molecular Function:
intermediate filament binding protein
transcription, DNA-templated
regulation of transcription, DNA-templated
cell adhesion
brain development
Wnt signaling pathway
single organismal cell-cell adhesion
adherens junction organization
negative regulation of canonical Wnt signaling pathway
morphogenesis of a polarized epithelium
salivary gland morphogenesis
keratinocyte differentiation
epithelial cell differentiation involved in salivary gland development
cell-cell junction assembly
mesodermal cell migration
cell migration involved in gastrulation
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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