MA5-15905 targets JUP in IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15905 immunogen is purified recombinant fragment of human JUP expressed in E. Coli. .
MA5-15905 detects JUP which has a predicted molecular weight of approximately 82kDa.
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
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Protein Aliases: ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; gamma-catenin; Junction plakoglobin
Gene Aliases: ARVD12; CTNNG; DP3; DPIII; JUP; PDGB; PKGB
UniProt ID: (Human) P14923
Entrez Gene ID: (Human) 3728