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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, KLH conjugated, corresponding to the second extracellular domain of human kappa-1 Opioid Receptor.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24534 detects Opioid Receptor, Kappa 1 in Human samples.
PA1-24534 has been successfully used in Immunohistochemistry procedures. Positive control: rat brain.
The PA1-24534 immunogen is a synthetic peptide, KLH conjugated, corresponding to the second extracellular domain of human kappa-1 Opioid Receptor. Sequence identity/similarity to mouse: 94/100%. rat: 94/100%.
Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles.
KOR1, an Opioid Receptor, plays a modulatory role in specific aspects of opioid function such as the control of pain. Its endogenous ligand, dynorphin A, is an important neurotransmitter in the central and peripheral nervous systems. KOR1 is believed to mediate sedation, analgesia, and diuresis. KOR1 has been reported to be expressed in the central and peripheral nervous systems, placenta, uterus, breast, and blood. ESTs have been isolated from placenta and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
kappa opioid receptor; Opiate receptor, kappa-1; opioid receptor, kappa 1
K-OR-1; KOR; KOR-1; OPRK; OPRK1