|Immunocytochemistry (ICC)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (aa sequence is considered to be commercially sensitive)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-20679 detects Metabotropic Glutamate Receptor 2 in Human samples.
PA1-20679 has been successfully used in Immunocytochemistry and Immunohistochemistry (Paraffin) procedures.
PA1-20679 immunogen corresponds to Synthetic peptide (aa sequence is considered to be commercially sensitive).
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: glutamate receptor homolog; glutamate receptor, metabotropic 2; Metabotropic glutamate receptor 2; mGluR2
Gene Aliases: GLUR2; GPRC1B; GRM2; mGlu2; MGLUR2
UniProt ID: (Human) Q14416
Entrez Gene ID: (Human) 2912
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