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Alomone Labs, LTD

mGluR1 (extracellular) Polyclonal Antibody, Atto™ 488

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mGluR1 (extracellular) Polyclonal Antibody, Atto™ 488

Product Details

AGC-006-AG-50UL

Applications
Tested Dilution
Publications

Multiplex Immunohistochemistry (mIHC)

1:20
-

Immunohistochemistry (Frozen) (IHC (F))

1:20
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)HEGVLNIDDYKIQMNK, corresponding to amino acids 501-516 of rat mGluR1, Extracellular, N-terminus
3D Epitope / Immunogen

Conjugate

Atto™ 488 Atto™ 488 Atto™ 488

Excitation/Emission Max

501/523 nm

Form

Lyophilized

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G protein coupled receptor family C group 1 member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; glutamate receptor, metabotropic 1; GRM1A; mGluR1; mGluR1a; protein phosphatase 1, regulatory subunit 85; unnamed protein product

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Gene Aliases: 4930455H15Rik; Gm10828; GPRC1A; MGLU1; MGLUR1; nmf373; PPP1R85; rcw; SCA44; SCAR13; wobl

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UniProt ID: (Human) Q13255, (Rat) P23385, (Mouse) P97772

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Entrez Gene ID: (Human) 2911, (Rat) 24414, (Mouse) 14816

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Function(s)
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity G protein-coupled neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential PLC activating G-protein coupled glutamate receptor activity fibronectin binding collagen binding estrogen receptor binding laminin binding protein sequestering activity
Process(es)
G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission locomotory behavior sensory perception of pain regulation of membrane potential positive regulation of MAPK cascade regulation of sensory perception of pain regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential synaptic signaling via neuropeptide regulation of glutamate secretion calcium-mediated signaling positive regulation of cell migration negative regulation of viral entry into host cell receptor-mediated virion attachment to host cell membrane depolarization synaptic transmission, GABAergic cellular response to electrical stimulus L-glutamate import across plasma membrane negative regulation of protein localization to plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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