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Invitrogen

mGluR1/mGluR5 Polyclonal Antibody

1 Reference
View all (2) mGluR1/mGluR5 antibodies
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Product Details

Applications
Tested Dilution
Publications
Western Blot (WB)
1:1000
-
Immunohistochemistry (IHC)
1:500
-
Immunohistochemistry - Free Floating (IHC (Free))
-
View 1 publication 1 publication
Dot blot (DB)
1:1000
-
Product Specifications
Species Reactivity
Rat
Published species
Rat
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal region of rat GRM5 conjugated to KLH
Conjugate
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2115762

Product Specific Information

This antibody is predicted to react with human and mouse based on 100% sequence homology.

This antibody is specific for the ~125 kDa monomer and the ~250 kDa dimmers of mGluR5 and mGluR1 in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Target Information

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: G protein coupled receptor family C group 1 member A; glutamate receptor; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; mGluR1; mGluR5; mGlurR1a

Gene Aliases: Gprc1a; Gprc1e; Grm1; Grm5; Mglur1; Mglur5

UniProt ID: (Rat) P23385, (Rat) P31424

Entrez Gene ID: (Rat) 24414, (Rat) 24418

Molecular Function: G-protein coupled receptor receptor

Function(s)
activation of MAPKK activity activation of MAPK activity G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission locomotory behavior regulation of glutamate secretion sensory perception of pain calcium-mediated signaling dimeric G-protein coupled receptor signaling pathway regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway membrane depolarization regulation of sensory perception of pain synaptic transmission, GABAergic regulation of synaptic transmission, glutamatergic cellular response to electrical stimulus activation of MAPKKK activity desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated protein phosphorylation learning negative regulation of locomotion phosphatidylinositol-mediated signaling regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity cognition
Process(es)
PLC activating G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity estrogen receptor binding identical protein binding calmodulin binding PDZ domain binding A2A adenosine receptor binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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