PA1-30151 detects mGluR2 + mGluR3 from rat samples.
Sequence is 100% conserved between mGluR2 and mGluR3. Predicted to react with human and mouse.
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: glutamate receptor; M mGlu3; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 3; mGluR2; mGluR3
Gene Aliases: Gprc1b; Gprc1c; Grm2; Grm3; Mglur2; Mglur3
Molecular Function: G-protein coupled receptor