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Invitrogen

mGluR5 Recombinant Rabbit Monoclonal Antibody (ST51-00)

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mGluR5 Recombinant Rabbit Monoclonal Antibody (ST51-00)

Product Details

MA5-32155

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ST51-00

Immunogen

Synthetic peptide within Human GRM5 aa 1,163-1,212.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809444

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A830007B11Rik; D16Ium24; D16Ium24e; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPCR family C; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5 homolog; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; mGlu1; mGluR; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; mGluR5f; mGluR5g; mGluR5h; mGluR5i; protein phosphatase 1, regulatory subunit 86; unnamed protein product; variant b of mGluR5

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Gene Aliases: 6430542K11Rik; Glu5R; GPRC1E; mGlu5; MGLUR5; mGluR5b; PPP1R86

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UniProt ID: (Human) P41594, (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Human) 2915, (Rat) 24418, (Mouse) 108071

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Function(s)
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding glutamate receptor activity protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential protein tyrosine kinase binding PLC activating G-protein coupled glutamate receptor activity calmodulin binding PDZ domain binding
Process(es)
temperature homeostasis response to amphetamine desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway positive regulation of cytosolic calcium ion concentration phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission learning or memory associative learning positive regulation of dopamine secretion operant conditioning protein targeting to nuclear inner membrane response to morphine positive regulation of MAPK cascade response to ethanol response to antibiotic positive regulation of long-term neuronal synaptic plasticity synapse organization positive regulation of calcium-mediated signaling cognition response to corticosterone regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential negative regulation of dendritic spine morphogenesis sensory perception of hot stimulus negative regulation of excitatory postsynaptic potential positive regulation of cellular response to hypoxia regulation of long term synaptic depression positive regulation of intracellular signal transduction positive regulation of sensory perception of pain cellular response to beta-amyloid conditioned place preference positive regulation of neural precursor cell proliferation protein phosphorylation phospholipase C-activating G-protein coupled receptor signaling pathway learning locomotory behavior phosphatidylinositol-mediated signaling regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission
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