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Rockland
mSlo maxi-K+ channel Monoclonal Antibody (S6-60)
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FIGURE: 1 / 2
mSlo maxi-K+ channel Antibody (200-301-G15) in IHC
Immunohistochemistry of mouse anti-mSlo maxi K+ channel antibody. Tissue: Mouse cerebellum tissue. Primary Antibody: mSlo maxi K+ channel antibody at 1 μg/mL for 1 hr at RT. Secondary antibody: Peroxidase mouse secondary at 1:10,000 for 45 min at RT. Localization: membrane. Staining: mSlo maxi K+ channel as white signal.
Product Details
200-301-G15
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
S6-60
Immunogen
mSlo maxi- K+ channel Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of mouse Slo1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; maxi-K channel HSLO; MaxiK; mSlo1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; stretch-activated Kca channel
Gene Aliases: 5730414M22Rik; bA205K10.1; BKCa; BKTM; hSlo; KCa1.1; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
UniProt ID: (Human) Q12791, (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Human) 3778, (Mouse) 16531, (Rat) 83731
actin binding
voltage-gated potassium channel activity
protein binding
calcium-activated potassium channel activity
metal ion binding
large conductance calcium-activated potassium channel activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
protein complex binding
protein homodimerization activity
ion channel
response to hypoxia
potassium ion transport
response to osmotic stress
cellular potassium ion homeostasis
response to carbon monoxide
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of apoptotic process
negative regulation of cell volume
response to calcium ion
micturition
smooth muscle contraction involved in micturition
potassium ion transmembrane transport
transport
ion transport
chemical synaptic transmission
sensory perception of sound
circadian rhythm
adult walking behavior
response to pH
neuronal action potential
response to corticosteroid
regulation of aldosterone metabolic process
vasodilation
regulation of vasodilation
auditory receptor cell differentiation
response to estrogen
locomotor rhythm
saliva secretion
cell maturation
neuromuscular process controlling balance
protein homooligomerization
protein homotetramerization
transmembrane transport
eye blink reflex
relaxation of vascular smooth muscle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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