Product References
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Equine veterinary journal
Bou T,Ding W,Ren X,Liu H,Gong W,Jia Z,Zhang X,Dugarjaviin M,Bai D
Mon Jan 01 00:00:00 UTC 2024
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
Cell proliferation
Li S,Liao Z,Yin H,Liu O,Hua W,Wu X,Zhang Y,Gao Y,Yang C
Wed Mar 01 00:00:00 UTC 2023
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
International ophthalmology
Liu W,Chen Y,Song X,Xue Y,Zhang Y
Mon May 01 00:00:00 UTC 2023
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Science China. Life sciences
Zhang M,Zhang B,Wang X,Song J,Tong M,Dong Z,Xu J,Liu M,Jiang Y,Wang N,Wang Y,Du Z,Liu Y,Zhang R,Xu C
Sat Apr 01 00:00:00 UTC 2023
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Journal of translational medicine
Zhong WJ,Zhang J,Duan JX,Zhang CY,Ma SC,Li YS,Yang NS,Yang HH,Xiong JB,Guan CX,Jiang ZX,You ZJ,Zhou Y
Mon Mar 06 00:00:00 UTC 2023
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Ecotoxicology and environmental safety
Liu X,Xi H,Han S,Zhang H,Hu J
Wed Mar 01 00:00:00 UTC 2023
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Cancers
Chen J,Feng D,Lu Y,Zhang Y,Jiang H,Yuan M,Xu Y,Zou J,Zhu Y,Zhang J,Ge C,Wang Y
Sun Mar 05 00:00:00 UTC 2023
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
The Journal of nutritional biochemistry
Lin G,Qi H,Guo X,Wang W,Zhang M,Gao X
Sat Apr 01 00:00:00 UTC 2023
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Experimental eye research
Zhang L,Xue K,Fan P,Chen C,Hu J,Huang J,Lu W,Xu J,Xu S,Ran J,Zhu S,Gan S
Sat Apr 01 00:00:00 UTC 2023
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Journal of natural products
Liu L,Shi D,Xia ZY,Wang BW,Wang XL,Wang XT,Wang GL,Li MJ,Zheng QS,Li D,Li BH
Fri Apr 28 00:00:00 UTC 2023
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Molecular carcinogenesis
Wu W,Chen X,Liu X,Bao HJ,Li QH,Xian JY,Lu BF,Zhao Y,Chen S
Sat Apr 01 00:00:00 UTC 2023
KIFC3 regulates progression of hepatocellular carcinoma via EMT and the AKT/mTOR pathway.
Experimental cell research
Lu S,Liu Y,Tian S,He Y,Dong W
Mon May 01 00:00:00 UTC 2023
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yang J,Bao S,Luo S,Jiang L,Li Q,Kong Y,Cao J
Wed Mar 01 00:00:00 UTC 2023
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Translational oncology
Deng Y,Ma J,Zhao S,Yang M,Sun Y,Zhang Q
Wed Feb 01 00:00:00 UTC 2023
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Phytochemistry
Wang J,Wang D,Feng L,Li X,Gong Y,Wang Z,Tan N,Han J
Sat Apr 01 00:00:00 UTC 2023
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway.
BMC cancer
Xue Z,Wang J,Wang Z,Liu J,Zhao J,Liu X,Zhang Y,Liu G,Zhao Z,Li W,Zhang Q,Li X,Huang B,Wang X
Mon Jun 26 00:00:00 UTC 2023
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Journal of orthopaedic translation
Lu R,Xu H,Deng X,Wang Y,He Z,Xu S,Liang S,Huang X,You H,Guo F,Cheng P,Chen AM
Wed Mar 01 00:00:00 UTC 2023
Combined Epimedii Folium and Ligustri Lucidi Fructus with dexamethasone alleviate the proliferation of airway smooth muscle cells by regulating apoptosis/autophagy.
Journal of ethnopharmacology
Long Y,Wang H,Ma Z,Li Y,Ma Z,Yu P,Tang X,Liu R
Thu Oct 05 00:00:00 UTC 2023
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Yan Y,Yu S,Fan Y
Wed Nov 01 00:00:00 UTC 2023
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Journal of ethnopharmacology
Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL
Sat Oct 28 00:00:00 UTC 2023
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Environmental toxicology
Zhuge R,Li Z,He C,Ma W,Yan J,Xue Q,Wang R,Liu Y,Lu R,Du H,Yin F,Guo L
Wed Feb 01 00:00:00 UTC 2023
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Environmental toxicology
Zhuge R,Li Z,He C,Ma W,Yan J,Xue Q,Wang R,Liu Y,Lu R,Du H,Yin F,Guo L
Wed Feb 01 00:00:00 UTC 2023
SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway.
Archives of biochemistry and biophysics
Wang H,Chen M,Yang C,Hu H,Jiang Y,Yang F,Lv L
Sat Jul 15 00:00:00 UTC 2023
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy.
Acta pharmacologica Sinica
Liu W,Zhu SO,Guo YL,Tu LF,Zhen YQ,Zhao RY,Ou-Yang L,Kurihara H,He RR,Liu B
Wed Mar 01 00:00:00 UTC 2023
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Liu W,Lin T,Gong L
Wed Mar 01 00:00:00 UTC 2023
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Journal of ethnopharmacology
Li J,Zhang M,Pei Y,Yang Q,Zheng L,Wang G,Sun Y,Yang W,Liu L
Wed Nov 15 00:00:00 UTC 2023
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Journal of physiology and biochemistry
Wang K,Li Z,Ding Y,Liu Z,Li Y,Liu X,Sun Y,Hong J,Zheng W,Qian L,Xu D
Mon May 01 00:00:00 UTC 2023
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Molecular cancer
Song R,Ma S,Xu J,Ren X,Guo P,Liu H,Li P,Yin F,Liu M,Wang Q,Yu L,Liu J,Duan B,Rahman NA,Wołczyński S,Li G,Li X
Mon Jan 23 00:00:00 UTC 2023
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Molecular cancer
Song R,Ma S,Xu J,Ren X,Guo P,Liu H,Li P,Yin F,Liu M,Wang Q,Yu L,Liu J,Duan B,Rahman NA,Wołczyński S,Li G,Li X
Mon Jan 23 00:00:00 UTC 2023
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy.
Frontiers in pharmacology
Hu BA,Li YL,Han HT,Lu B,Jia X,Han L,Ma WX,Zhu P,Wang ZH,Zhang W,Zhong M,Zhang L
Tue Feb 07 00:00:00 UTC 2023
Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
Gastroenterology
Yang XM,Wang XQ,Hu LP,Feng MX,Zhou YQ,Li DX,Li J,Miao XC,Zhang YL,Yao LL,Nie HZ,Huang S,Xia Q,Zhang XL,Jiang SH,Zhang ZG
Fri Sep 01 00:00:00 UTC 2023
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Biochemical and biophysical research communications
Ke C,Zhao S,Wang L,Zhang M,Gao X
Sun Feb 05 00:00:00 UTC 2023
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Journal of ethnopharmacology
Wei P,He Q,Liu T,Zhang J,Shi K,Zhang J,Liu S
Sat Mar 25 00:00:00 UTC 2023
Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.
Ecotoxicology and environmental safety
Li X,Wang W,Hou Y,Li G,Yi H,Cui S,Zhang J,He X,Zhao H,Yang Z,Qiu Y,Liu Z,Xie J
Thu Jun 01 00:00:00 UTC 2023
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Amino acids
Xu M,Zhou Y,Fan S,Zhang M,Gao X
Wed Feb 01 00:00:00 UTC 2023
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Redox biology
Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S
Mon May 01 00:00:00 UTC 2023
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
International journal of biological sciences
Zhong WJ,Liu T,Yang HH,Duan JX,Yang JT,Guan XX,Xiong JB,Zhang YF,Zhang CY,Zhou Y,Guan CX
Wed Jan 04 00:00:00 UTC 2023
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Journal of controlled release : official journal of the Controlled Release Society
Liang X,Yang Y,Huang C,Ye Z,Lai W,Luo J,Li X,Yi X,Fan JB,Wang Y,Wang Y
Sat Apr 01 00:00:00 UTC 2023
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Cancers
Zhou Z,Zhang G,Li T,Ai J,Li W,Zeng S,Ye M,Liu Q,Xiao J,Li Y,Tan G,Zhang X
Wed Jan 18 00:00:00 UTC 2023
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cell death & disease
Cai J,Ye Z,Hu Y,Ye L,Gao L,Wang Y,Sun Q,Tong S,Zhang S,Wu L,Yang J,Chen Q
Sat Mar 25 00:00:00 UTC 2023
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Theriogenology
Xi H,Hu Z,Han S,Liu X,Wang L,Hu J
Sun Jan 01 00:00:00 UTC 2023
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
European journal of pharmacology
Zhou W,Wang C,Zhang B,Gou S
Wed Jul 05 00:00:00 UTC 2023
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Journal of orthopaedic translation
Chen D,Jiang X,Zou H
Wed Mar 01 00:00:00 UTC 2023
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Biochemical and biophysical research communications
Yang C,Deng Z,Zeng Q,Chang X,Wu X,Li G
Sun Jun 18 00:00:00 UTC 2023
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway.
Biochemical and biophysical research communications
Yang C,Deng Z,Zeng Q,Chang X,Wu X,Li G
Sun Jun 18 00:00:00 UTC 2023
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
PloS one
Zheng W,Guo Y,Zhang G,Bai J,Song Y,Song X,Zhu Q,Bao X,Wu G,Zhang C
Mon Jun 26 00:00:00 UTC 2023
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Journal of ethnopharmacology
Zhang PP,Zhuo BY,Duan ZW,Li X,Huang SL,Cao Q,Zhao T,Wei SL,Hu XH,Zhang Y
Thu Aug 10 00:00:00 UTC 2023
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Cancers
Jin L,Mi T,Wu X,Wang Z,Zhang Z,Liu J,Wang Z,Wang J,Li M,Ren C,Guo P,He D
Tue Mar 28 00:00:00 UTC 2023
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
International heart journal
Shi G,Zeng L,Shi J,Chen Y
Fri Jun 02 00:00:00 UTC 2023
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Journal of medicinal chemistry
Wang Z,Tan M,Su W,Huang W,Zhang J,Jia F,Cao G,Liu X,Song H,Ran H,Nie G,Wang H
Thu May 11 00:00:00 UTC 2023
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Oncology letters
Zhou H,Yun X,Shu Y,Xu K
Wed Mar 01 00:00:00 UTC 2023
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Toxicology
Zhang J,Zha Y,Jiao Y,Li Y,Zhang S
Wed Feb 01 00:00:00 UTC 2023
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Chinese journal of integrative medicine
Ge XF,Li SS,Liu YH,Lu MQ,Su HN,Yang X,Sun XW
Thu Jun 01 00:00:00 UTC 2023
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
iScience
Lu R,Wei Z,Wang Z,Xu S,Sun K,Cheng P,Huang X,You H,Guo F,Liang S,Chen AM
Fri Feb 17 00:00:00 UTC 2023
Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.
Molecular medicine reports
Li X,Huang L,Kong L,Su Y,Zhou H,Ji P,Sun R,Wang C,Li W,Li W
Sun Jan 01 00:00:00 UTC 2023
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Phytotherapy research : PTR
Zhang H,Xie X,Shi J,Zhao Q,Luo D,Hao J,Zhou Y,Han G,Pang X
Wed Feb 01 00:00:00 UTC 2023
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Neural regeneration research
Sun X,Huang LY,Pan HX,Li LJ,Wang L,Pei GQ,Wang Y,Zhang Q,Cheng HX,He CQ,Wei Q
Mon May 01 00:00:00 UTC 2023
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Journal of ethnopharmacology
Li Y,Zang J,Wang X,Feng X,Qiu F
Fri Feb 10 00:00:00 UTC 2023
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Cell death discovery
Ouyang S,Zeng Z,Liu Z,Zhang Z,Sun J,Wang X,Ma M,Ye X,Yu J,Kang W
Wed Feb 02 00:00:00 UTC 2022
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Journal of orthopaedic translation
Cao Y,Li Y,Fu SC,Shen J,Zhang H,Jiang C,Shu-Hang Yung P
Sun May 01 00:00:00 UTC 2022
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells.
Endocrinology
Ali Y,Gomez-Sanchez EP,Gomez-Sanchez CE
Mon Nov 14 00:00:00 UTC 2022
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Phytotherapy research : PTR
Zhai Y,Sun J,Sun C,Zhao H,Li X,Yao J,Su J,Xu X,Xu X,Hu J,Daglia M,Han B,Kai G
Tue Nov 01 00:00:00 UTC 2022
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Life (Basel, Switzerland)
Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S
Tue Sep 20 00:00:00 UTC 2022
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
BMC medical genomics
Li B,Ge N,Pan Z,Hou C,Xie K,Wang D,Liu J,Wan J,Deng F,Li M,Luo S
Tue Sep 13 00:00:00 UTC 2022
Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway.
The Journal of clinical investigation
Wang JZ,Zhu H,You P,Liu H,Wang WK,Fan X,Yang Y,Xu K,Zhu Y,Li Q,Wu P,Peng C,Wong CC,Li K,Shi Y,Zhang N,Wang X,Zeng R,Huang Y,Yang L,Wang Z,Hui J
Fri Apr 15 00:00:00 UTC 2022
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Evidence-based complementary and alternative medicine : eCAM
Zuo X,Shi X,Zhang X,Chen Z,Yang Z,Pan X,Lai R,Zhao Z
Fri Apr 08 00:00:00 UTC 2022
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Autophagy
Liu K,Qiu D,Liang X,Huang Y,Wang Y,Jia X,Li K,Zhao J,Du C,Qiu X,Cui J,Xiao Z,Qin Y,Zhang Q
Fri Apr 01 00:00:00 UTC 2022
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Journal of cardiovascular translational research
Wang K,Li Z,Sun Y,Liu X,Ma W,Ding Y,Hong J,Qian L,Xu D
Mon Aug 01 00:00:00 UTC 2022
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
International journal of environmental research and public health
Niu Z,Lin J,Hao C,Xu X,Wang C,Dai K,Deng X,Deng M,Guo Y,Yao W
Mon Jul 18 00:00:00 UTC 2022
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Ecotoxicology and environmental safety
Liu R,Cai D,Li X,Liu B,Chen J,Jiang X,Li H,Li Z,Teerds K,Sun J,Bai W,Jin Y
Fri Jul 01 00:00:00 UTC 2022
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Ecotoxicology and environmental safety
Liu R,Cai D,Li X,Liu B,Chen J,Jiang X,Li H,Li Z,Teerds K,Sun J,Bai W,Jin Y
Fri Jul 01 00:00:00 UTC 2022
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
International journal of molecular sciences
Chen W,Zhu L,Wang L,Zeng J,Wen M,Xu X,Zou L,Huang F,Huang Q,Qin D,Mei Q,Yang J,Wang Q,Wu J
Mon Nov 14 00:00:00 UTC 2022
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
Cell death discovery
Zhao G,Li S,Wang Q,Wu W,Fu X,Zhu C,Wang W,Wang X
Mon Sep 26 00:00:00 UTC 2022
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Pharmaceuticals (Basel, Switzerland)
Sun Y,Li H,Liu L,Bai X,Wu L,Shan J,Sun X,Wang Q,Guo Y
Thu Dec 29 00:00:00 UTC 2022
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Oxidative medicine and cellular longevity
Tu Z,Li J,Long X,Wu L,Zhu X,Huang K
Mon May 23 00:00:00 UTC 2022
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Pathology, research and practice
Chen L,Kang Y,Jiang Y,You J,Huang C,Xu X,Chen F
Thu Sep 01 00:00:00 UTC 2022
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
Neural regeneration research
Yan JN,Zhang HY,Li JR,Chen Y,Jiang YC,Shen JB,Ke KF,Gu XS
Wed Jun 01 00:00:00 UTC 2022
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Frontiers in cardiovascular medicine
Osuru HP,Lavallee M,Thiele RH
Sat Aug 06 00:00:00 UTC 2022
SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Digestive diseases and sciences
Nie K,Cai M
Fri Jul 01 00:00:00 UTC 2022
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
BMC cancer
Tan Y,Chen Q,Pan S,An W,Xu H,Xing Y,Zhang J
Sat Apr 30 00:00:00 UTC 2022
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fitoterapia
Fan Y,Wu H,Xiong L,Luo F,Li Q,Wang D,Zhong T
Tue Nov 01 00:00:00 UTC 2022
The Role of Syncytin in Placental Angiogenesis and Fetal Growth.
Frontiers in cell and developmental biology
Wang YN,Ye Y,Zhou D,Guo ZW,Xiong Z,Gong XX,Jiang SW,Chen H
Sat Jul 16 00:00:00 UTC 2022
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Blood advances
Wang C,Wang Y,Zuo N,Fang S,Shi J
Tue Aug 09 00:00:00 UTC 2022
Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring.
Human & experimental toxicology
Yang Q,Mao Y,Wang J,Yu H,Zhang X,Pei X,Duan Z,Xiao C,Ma M
Mon Sep 26 00:00:00 UTC 2022
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Journal of agricultural and food chemistry
Yan S,Chen J,Zhu L,Guo T,Qin D,Hu Z,Han S,Zhou Y,Akan OD,Wang J,Luo F,Lin Q
Wed Jun 01 00:00:00 UTC 2022
Theabrownins Produced via Chemical Oxidation of Tea Polyphenols Inhibit Human Lung Cancer Cells in vivo and in vitro by Suppressing the PI3K/AKT/mTOR Pathway Activation and Promoting Autophagy.
Frontiers in nutrition
Wang Y,Yuan Y,Wang C,Wang B,Zou W,Zhang N,Chen X
Tue May 10 00:00:00 UTC 2022
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Molecular and cellular endocrinology
Xi H,Ren F,Li Y,Xian M,Wang L,Hu J
Sat Jan 15 00:00:00 UTC 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 UTC 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 UTC 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 UTC 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 UTC 2022
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
International journal of biological sciences
Zhang Z,Xu P,Hu Z,Fu Z,Deng T,Deng X,Peng L,Xie Y,Long L,Zheng D,Shen P,Zhang M,Gong B,Zhu Z,Lin J,Chen R,Liu Z,Yang H,Li R,Fang W
Wed Jan 04 00:00:00 UTC 2023
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Genetics research
Lin L,Wang X,Zhao W,Chen Y
Mon Nov 07 00:00:00 UTC 2022
MCPIP1 alleviates inflammatory response through inducing autophagy in Aspergillus fumigatus keratitis.
International immunopharmacology
Han F,Shen L,Ma H,Wang L,Guo H,Wu X
Thu Dec 01 00:00:00 UTC 2022
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Journal of ethnopharmacology
Jin D,Liu F,Yu M,Zhao Y,Yan G,Xue J,Sun Y,Zhao D,Li X,Qi W,Wang X
Fri Jul 15 00:00:00 UTC 2022
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Frontiers in endocrinology
Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W
Tue Dec 20 00:00:00 UTC 2022
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Frontiers in pharmacology
Xin M,Gao Q,Xiang X,Xu J,Jiao Y,Li X,Zhang X,Jia X
Wed Nov 01 00:00:00 UTC 2023
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Materials today. Bio
Liu L,Li X,Bu W,Jin N,Meng Y,Wang Y,Wang D,Xu X,Zhou D,Sun H
Thu Dec 01 00:00:00 UTC 2022
Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
International immunopharmacology
Lu Y,Zhong W,Liu Y,Chen W,Zhang J,Zeng Z,Huang H,Qiao Y,Wan X,Meng X,Cai S,Dong H
Tue Mar 01 00:00:00 UTC 2022
The diagnostic and prognostic significance of small nuclear ribonucleoprotein Sm D1 aberrantly high expression in hepatocellular carcinoma.
Journal of Cancer
Wang H,Xu F,Lu L,Yang F,Huang X,Lv L,Hu H,Jiang Y
Tue Jan 04 00:00:00 UTC 2022
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Cancer science
Zhu Y,Yang Y,Bu H,Huang H,Chen H,Ran J,Qin L,Ni Y,Yao M,Song T,Li M,Yang Y,Guo T,Chao N,Liu Z,Li W,Zhang L
Tue Nov 01 00:00:00 UTC 2022
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Metabolites
Liu M,Yue Z,Zhang B,Li F,Liu L,Li F
Thu Aug 25 00:00:00 UTC 2022
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Experimental cell research
Xu P,Li X,Tang C,Wang T,Xu J
Tue Mar 01 00:00:00 UTC 2022
Dickkopf1 (Dkk1) Alleviates Vascular Calcification by Regulating the Degradation of Phospholipase D1 (PLD1).
Journal of cardiovascular translational research
Li X,Liu XL,Li X,Zhao YC,Wang QQ,Zhong HY,Liu DD,Yuan C,Zheng TF,Zhang M
Thu Dec 01 00:00:00 UTC 2022
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Frontiers in pharmacology
Cheng Z,Luo X,Zhu Z,Huang Y,Yan X
Sat Jul 16 00:00:00 UTC 2022
Anti-fatigue effects of fermented soybean protein peptides in mice.
Journal of the science of food and agriculture
Fang L,Zhang RX,Wei Y,Ling K,Lu L,Wang J,Pan XC,Cai MY
Sun May 01 00:00:00 UTC 2022
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Journal of gastrointestinal oncology
Yin L,Feng S,Sun Y,Jiang Y,Tang C,Sun D
Sat Oct 01 00:00:00 UTC 2022
Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung's disease by targeting mTOR.
Pediatric surgery international
Daiyue Y,Yang Y,Zhaorong H,Yi L,Chen W,Caiyun L,Yuqian S,Liucheng Y,Kai W
Mon Dec 19 00:00:00 UTC 2022
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Shi XY,Zhang XL,Shi QY,Qiu X,Wu XB,Zheng BL,Jiang HX,Qin SY
Wed Jun 01 00:00:00 UTC 2022
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Journal of agricultural and food chemistry
Li R,Xiao J,Cao Y,Huang Q,Ho CT,Lu M
Wed Jan 26 00:00:00 UTC 2022
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Environmental toxicology
Zhao Y,Mao A,Zhang R,Guan S,Lu J
Tue Mar 01 00:00:00 UTC 2022
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Journal of orthopaedic surgery (Hong Kong)
Zhang C,Li Z,Li L,Li S,Yang L,Chen L,Zhang X,Yang S,Guo Y
Tue Nov 01 00:00:00 UTC 2022
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Cell death & disease
Jia X,Xin M,Xu J,Xiang X,Li X,Jiao Y,Wang L,Jiang J,Pang F,Zhang X,Zhang J
Tue Aug 30 00:00:00 UTC 2022
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Oxidative medicine and cellular longevity
Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S
Thu Mar 24 00:00:00 UTC 2022
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
Frontiers in oncology
Li Y,Liu H,Liu X,Xiao B,Zhang M,Luo Y,Li M,Yang J
Sat Apr 09 00:00:00 UTC 2022
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Drug development research
Yuan D,Guo T,Qian H,Ge H,Zhao Y,Huang A,Wang X,Cao X,Zhu D,He C,Yu H
Thu Sep 01 00:00:00 UTC 2022
Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.
Journal of ethnopharmacology
Li N,Li M,Xiu L,Liao W,Ren Y,Liu H,Chen S,Chen F,Yu X,Fan A,Huo M,He J,Zhong G
Wed Oct 05 00:00:00 UTC 2022
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Journal of inflammation research
Hao M,Ding C,Sun S,Peng X,Liu W
Wed Sep 07 00:00:00 UTC 2022
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Cell death discovery
Benedetti R,Romeo MA,Arena A,Gilardini Montani MS,Di Renzo L,D'Orazi G,Cirone M
Sat Jun 25 00:00:00 UTC 2022
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
International journal of molecular sciences
Yang J,Li J,Guo H,Zhang Y,Guo Z,Liu Y,Huo T
Thu May 19 00:00:00 UTC 2022
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
Neural plasticity
Tian J,Wang Z,Ren Y,Jiang Y,Zhao Y,Li M,Zhang Z
Fri Jun 10 00:00:00 UTC 2022
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Ecotoxicology and environmental safety
Wu M,Cong Y,Wang K,Yu H,Zhang X,Ma M,Duan Z,Pei X
Fri Apr 01 00:00:00 UTC 2022
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Deng X,Hao C,Li Y,Guo Y,Si H,He J,Deng M,Niu Z,Wang C,Xu X,Dai K,Yao W
Tue Nov 01 00:00:00 UTC 2022
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Frontiers in pharmacology
Fan XX,Sun WY,Li Y,Tang Q,Li LN,Yu X,Wang SY,Fan AR,Xu XQ,Chang HS
Tue Sep 13 00:00:00 UTC 2022
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Aging and disease
Huang L,Chen Y,Liu R,Li B,Fei X,Li X,Liu G,Li Y,Xu B,Fang W
Sat Oct 01 00:00:00 UTC 2022
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Biochemical and biophysical research communications
Cheng F,Dun Y,Cheng J,Ripley-Gonzalez JW,Jiang W,You B,Liu S
Sat Apr 23 00:00:00 UTC 2022
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Cancer letters
Chen C,Guo Y,Huang Q,Wang B,Wang W,Niu J,Lou J,Xu J,Ren T,Huang Y,Guo W
Tue Jun 28 00:00:00 UTC 2022
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Frontiers in oncology
Glathar AR,Oyelakin A,Gluck C,Bard J,Sinha S
Sat Jul 16 00:00:00 UTC 2022
YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.
Scientific reports
Zhan Y,Chen X,Zheng H,Luo J,Yang Y,Ning Y,Wang H,Zhang Y,Zhou M,Wang W,Fan S
Tue Mar 08 00:00:00 UTC 2022
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Cancer cell international
Li W,Huang BS,Xiong YY,Yang LJ,Wu LX
Tue Jan 18 00:00:00 UTC 2022
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
International journal of oncology
Huang X,Huang Y,Lv Z,Wang T,Feng H,Wang H,Du S,Wu S,Shen D,Wang C,Li H,Wang B,Ma X,Zhang X
Fri Jul 01 00:00:00 UTC 2022
SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment.
Heliyon
Liu Y,Ma G,Liu J,Zheng H,Huang G,Song Q,Pang Z,Du J
Sat Oct 01 00:00:00 UTC 2022
Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2.
International journal of molecular sciences
Liao WL,Liu YF,Ying TH,Shieh JC,Hung YT,Lee HJ,Shen CY,Cheng CW
Mon Dec 26 00:00:00 UTC 2022
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
Development (Cambridge, England)
Kong X,Shu X,Wang J,Liu D,Ni Y,Zhao W,Wang L,Gao Z,Chen J,Yang B,Guo X,Wang Z
Thu Dec 15 00:00:00 UTC 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 UTC 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 UTC 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 UTC 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 UTC 2022
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Stem cell research & therapy
Zhao X,Sun W,Guo B,Cui L
Sat Aug 13 00:00:00 UTC 2022
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.
Molecular cancer
Li X,Wang J,Lin W,Yuan Q,Lu Y,Wang H,Chen Y,Chen L,Dai P,Long H,Li X
Thu Jun 23 00:00:00 UTC 2022
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Frontiers in cell and developmental biology
Shen G,Wang H,Zhu N,Lu Q,Liu J,Xu Q,Huang D
Sat Jul 16 00:00:00 UTC 2022
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
The Journal of nutritional biochemistry
Miao Y,Geng Y,Yang L,Zheng Y,Dai Y,Wei Z
Tue Mar 01 00:00:00 UTC 2022
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
The Journal of nutritional biochemistry
Miao Y,Geng Y,Yang L,Zheng Y,Dai Y,Wei Z
Tue Mar 01 00:00:00 UTC 2022
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's disease by regulating the metabolism of astrocytes.
Psychopharmacology
Wang C,Zheng D,Weng F,Jin Y,He L
Sat Jan 01 00:00:00 UTC 2022
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Chemico-biological interactions
Zhong Y,Sun D,Yao Y,Liu Q,Guo T,Wang X,Peng X
Tue Mar 01 00:00:00 UTC 2022
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Cell cycle (Georgetown, Tex.)
Wen C,Lin L,Zou R,Lin F,Liu Y
Tue Feb 01 00:00:00 UTC 2022
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
Journal of Cancer
Zhu N,Chen X,Zhao J,Fang L,Yao Y,Zhou F,Tao L,Xu Q
Tue Sep 20 00:00:00 UTC 2022
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Frontiers in pharmacology
Liu J,Zhang L,Wang Z,Chen S,Feng S,He Y,Zhang S
Sat Jul 16 00:00:00 UTC 2022
miR-145-5p affects autophagy by targeting CaMKIIδ in atherosclerosis.
International journal of cardiology
Zhang X,Zai L,Tao Z,Wu D,Lin M,Wan J
Mon Aug 01 00:00:00 UTC 2022
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Evidence-based complementary and alternative medicine : eCAM
Xu G,Ma T,Zhou C,Zhao F,Peng K,Li B
Sat Jul 16 00:00:00 UTC 2022
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Bioengineered
Liu D,Bi X,Yang Y
Tue Mar 01 00:00:00 UTC 2022
Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.
Bioengineered
Liu D,Bi X,Yang Y
Tue Mar 01 00:00:00 UTC 2022
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
The FEBS journal
Xu Z,Li X,Ding Z,Zhang Y,Peng Z,Yang X,Cao W,Du R
Thu Dec 01 00:00:00 UTC 2022
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.
Journal of experimental & clinical cancer research : CR
Ye D,Xu H,Xia H,Zhang C,Tang Q,Bi F
Tue May 18 00:00:00 UTC 2021
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Annals of the New York Academy of Sciences
Zheng J,Zhu X,He Y,Hou S,Liu T,Zhi K,Hou T,Gao L
Mon Feb 01 00:00:00 UTC 2021
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.
Stem cell research & therapy
Shu X,Cao KY,Liu HQ,Yu L,Sun LX,Yang ZH,Wu CA,Ran YL
Fri Feb 12 00:00:00 UTC 2021
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Journal of hazardous materials
Xiaoli F,Yaqing Z,Ruhui L,Xuan L,Aijie C,Yanli Z,Chen H,Lili C,Longquan S
Sun Aug 15 00:00:00 UTC 2021
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Molecular medicine reports
Zhu Y,Su Y,Zhang J,Zhang Y,Li Y,Han Y,Dong X,Li W,Li W
Tue Jun 01 00:00:00 UTC 2021
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Cancer cell international
Liu X,Yang J,Yang C,Huang X,Han M,Kang F,Li J
Thu Nov 25 00:00:00 UTC 2021
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Fan Y,Lu J,Liu J,Zhang R,Yu Z,Guan S
Mon Nov 01 00:00:00 UTC 2021
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
Archives of biochemistry and biophysics
Xia F,Xiang S,Chen Z,Song L,Li Y,Liao Z,Ge B,Zhou B
Wed Dec 15 00:00:00 UTC 2021
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Scientific reports
Qi R,Sun J,Qiu X,Zhang Y,Wang J,Wang Q,Huang J,Ge L,Liu Z
Thu May 27 00:00:00 UTC 2021
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Frontiers in cardiovascular medicine
Hua L,Zhou Y,Hou C,Chen J,Wang Y,Zhang S,Zhou H,He S,Jia E
Tue Sep 14 00:00:00 UTC 2021
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Nutrients
Lin L,Zeng L,Liu A,Yuan D,Peng Y,Zhang S,Li Y,Chen J,Xiao W,Gong Z
Wed Nov 17 00:00:00 UTC 2021
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Journal of oncology
Hu C,Cao Y,Li P,Tang X,Yang M,Gu S,Xiong K,Li T,Xiao T
Mon Apr 25 00:00:00 UTC 2022
CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.
Cell death & disease
Zhang S,Lu Y,Jiang HY,Cheng ZM,Wei ZJ,Wei YH,Liu T,Xia BJ,Zhao XY,Huang Y,Zou X,Liu R,Zhou S
Wed Jun 09 00:00:00 UTC 2021
2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Journal of agricultural and food chemistry
Wu X,Li J,Wang S,Jiang L,Sun X,Liu X,Yao X,Zhang C,Wang N,Yang G
Wed May 05 00:00:00 UTC 2021
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Journal of experimental & clinical cancer research : CR
Liu S,Chen L,Chen H,Xu K,Peng X,Zhang M
Fri Feb 12 00:00:00 UTC 2021
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
BMC cancer
Wang F,Wang L,Qu C,Chen L,Geng Y,Cheng C,Yu S,Wang D,Yang L,Meng Z,Chen Z
Mon Apr 12 00:00:00 UTC 2021
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Food & function
Xian M,Cai J,Zheng K,Liu Q,Liu Y,Lin H,Liang S,Wang S
Tue Sep 07 00:00:00 UTC 2021
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Scientific reports
Zhao Y,Liu X,Zheng Y,Liu W,Ding C
Mon Oct 18 00:00:00 UTC 2021
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Frontiers in cell and developmental biology
Deng C,Hu F,Zhao Z,Zhou Y,Liu Y,Zhang T,Li S,Zheng W,Zhang W,Wang T,Ma X
Fri Jan 21 00:00:00 UTC 2022
Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.
European journal of pharmacology
Din SRU,Nisar MA,Ramzan MN,Saleem MZ,Ghayas H,Ahmad B,Batool S,Kifayat K,Guo X,Huang M,Zhong M
Wed Sep 15 00:00:00 UTC 2021
Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.
Behavioural brain research
So LY,Miller JE
Mon Feb 01 00:00:00 UTC 2021
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Bioorganic chemistry
Ma Y,Yang X,Han H,Wen Z,Yang M,Zhang Y,Fu J,Wang X,Yin T,Lu G,Qi J,Lin H,Wang X,Yang Y
Tue Jun 01 00:00:00 UTC 2021
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Experimental and therapeutic medicine
Qu G,He T,Dai A,Zhao Y,Guan D,Li S,Shi H,Gan W,Zhang A
Wed Dec 01 00:00:00 UTC 2021
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
BMC cancer
Liu C,Zhou X,Pan Y,Liu Y,Zhang Y
Tue Jun 22 00:00:00 UTC 2021
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Molecular medicine reports
Liu Z,Ma T,Duan J,Liu X,Liu L
Mon Feb 01 00:00:00 UTC 2021
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 UTC 2022
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea.
EMBO molecular medicine
Deng Z,Chen M,Liu Y,Xu S,Ouyang Y,Shi W,Jian D,Wang B,Liu F,Li J,Shi Q,Peng Q,Sha K,Xiao W,Liu T,Zhang Y,Zhang H,Wang Q,Sun L,Xie H,Li J
Fri May 07 00:00:00 UTC 2021
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chen X,Tang H,Liang Y,Wu P,Xie L,Ding Y,Yang P,Long B,Lin J
Wed Dec 01 00:00:00 UTC 2021
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chen X,Tang H,Liang Y,Wu P,Xie L,Ding Y,Yang P,Long B,Lin J
Wed Dec 01 00:00:00 UTC 2021
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Histology and histopathology
Ji Q,Qiao X,Liu Y,Wang D
Thu Apr 01 00:00:00 UTC 2021
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Frontiers in medicine
Yao M,Zhang J,Li Z,Bai X,Ma J,Li Y
Wed Mar 10 00:00:00 UTC 2021
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
American journal of physiology. Heart and circulatory physiology
Sun Z,Zhang L,Li L,Shao C,Liu J,Zhou M,Wang Z
Fri Jan 01 00:00:00 UTC 2021
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Research in veterinary science
Xing Y,Wang L,Xu G,Guo S,Zhang M,Cheng G,Liu Y,Liu J
Mon Nov 01 00:00:00 UTC 2021
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
International immunopharmacology
Zhao P,Cai Z,Tian Y,Li J,Li K,Li M,Bai Y,Li J
Wed Dec 01 00:00:00 UTC 2021
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
International journal of medical sciences
Du P,Luo K,Li G,Zhu J,Xiao Q,Li Y,Zhang X
Tue Mar 15 00:00:00 UTC 2022
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Life sciences
Liu H,Bian W,Yang D,Yang M,Luo H
Fri Jan 01 00:00:00 UTC 2021
Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.
Neuroscience
Liu D,Cai X,Wang L,Yi F,Liao W,Huang R,Fang C,Chen J,Zhou J
Fri Oct 01 00:00:00 UTC 2021
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Journal of bone oncology
Guo H,Peng J,Hu J,Chang S,Liu H,Luo H,Chen X,Tang H,Chen Y
Wed Dec 01 00:00:00 UTC 2021
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Journal of biochemical and molecular toxicology
Man S,Wu Z,Sun R,Guan Q,Li Z,Zuo D,Zhang W,Wu Y
Sun Aug 01 00:00:00 UTC 2021
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
ACS chemical neuroscience
Lu C,Liu X,Li J,Huang Y,Huang X,Dai G,Wu L
Wed Oct 20 00:00:00 UTC 2021
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.
Molecular nutrition & food research
Yang L,Cao N,Miao Y,Dai Y,Wei Z
Fri Oct 01 00:00:00 UTC 2021
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
The American journal of Chinese medicine
Qiao D,Jin J,Xing J,Zhang Y,Jia N,Ren X,Lin Z,Jin N,Chen L,Piao Y
Thu Aug 26 00:00:00 UTC 2021
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
American journal of translational research
Deng L,Wu X,Zhu X,Yu Z,Liu Z,Wang J,Zheng Y
Wed Feb 03 00:00:00 UTC 2021
Compound essential oils relieve oxidative stress caused by PM2 .5 exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Environmental toxicology
Ren F,Xu X,Xu J,Mei Y,Zhang J,Wang X,Li F
Wed Sep 01 00:00:00 UTC 2021
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
Hepatology communications
Kim HJ,Han YH,Kim JY,Lee MO
Wed Dec 01 00:00:00 UTC 2021
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.
Hepatology communications
Kim HJ,Han YH,Kim JY,Lee MO
Wed Dec 01 00:00:00 UTC 2021
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Evidence-based complementary and alternative medicine : eCAM
Yang R,Wen J,Yang T,Dai C,Zhao Y
Thu Apr 28 00:00:00 UTC 2022
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Journal of cellular biochemistry
Zheng Y,Nie P,Xu S
Mon Jun 01 00:00:00 UTC 2020
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Oncology reports
Wu G,Long Y,Lu Y,Feng Y,Yang X,Xu X,Yao D
Wed Jul 01 00:00:00 UTC 2020
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cellular signalling
Cooper LM,Hanson A,Kavanagh JA,Waddell DS
Mon Jun 01 00:00:00 UTC 2020
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
BioMed research international
Li R,Liu W,Ou L,Gao F,Li M,Wang L,Wei P,Miao F
Fri Apr 23 00:00:00 UTC 2021
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Nature communications
Zhou X,Zhong Y,Molinar-Inglis O,Kunkel MT,Chen M,Sun T,Zhang J,Shyy JY,Trejo J,Newton AC,Zhang J
Mon Nov 30 00:00:00 UTC 2020
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Human & experimental toxicology
Chen M,Zhu LL,Su JL,Li GL,Wang J,Zhang YN
Sat Feb 01 00:00:00 UTC 2020
Dietary Baicalin Zinc Supplementation Alleviates Oxidative Stress and Enhances Nutrition Absorption in Deoxynivalenol Challenged Pigs.
Current drug metabolism
Zha A,Cui Z,Qi M,Liao S,Chen L,Liao P,Tan B
Thu Aug 05 00:00:00 UTC 2021
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Oncology reports
Yan X,Yang C,Hu W,Chen T,Wang Q,Pan F,Qiu B,Tang B
Wed Jul 01 00:00:00 UTC 2020
QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy.
Journal of cellular and molecular medicine
Lv S,Yuan P,Dong J,Lu C,Li M,Qu F,Zhu Y,Yuan Z,Zhang J
Thu Oct 01 00:00:00 UTC 2020
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Technology in cancer research & treatment
Meng Q,Xue H
Mon Sep 21 00:00:00 UTC 2020
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
Molecular medicine reports
Ran Z,Zhang Y,Wen X,Ma J
Fri Feb 01 00:00:00 UTC 2019
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Cancer cell international
Zhang C,Wang B,Wang X,Sheng X,Cui Y
Tue Apr 12 00:00:00 UTC 2022
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Artificial organs
Zeng X,Wang S,Li S,Yang Y,Fang Z,Huang H,Wang Y,Fan X,Ye Q
Sun Dec 01 00:00:00 UTC 2019
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Oncology research
Liu X,Tan X,Liu P,Wu Y,Qian S,Zhang X
Thu Aug 23 00:00:00 UTC 2018
