|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||A recombinant full length human p19 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 3 publications below|
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation.
37-8700 was used in western blot to study the role of p19INK4d in the repair machinery for DNA damage
|Sonzogni SV,Ogara MF,Castillo DS,Sirkin PF,Radicella JP,Cánepa ET||Molecular and cellular biochemistry (398:63)||2015|
p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation.
37-8700 was used in western blot to study the role of p19INK4d in the initiation and maintenance of cellular senescence
|Sonzogni SV,Ogara MF,Belluscio LM,Castillo DS,Scassa ME,Cánepa ET||Biochimica et biophysica acta (1840:2171)||2014|
|ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.||Koyama M,Matsuzaki Y,Yogosawa S,Hitomi T,Kawanaka M,Sakai T||Molecular cancer therapeutics (6:1579)||2007|