Suggested positive control: HeLa nuclear extract.
p300 is a relatively stable, ubiquitously expressed, nuclear phosphoprotein which is conserved among a variety of mammalian species. It is actively synthesized and phosphorylated in both quiescent and proliferating cells. Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of HAT activity, it has been suggested CBP and p300 may play a direct role in activating chromatin for transcription.
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Protein Aliases: Cyclic AMP responsive enhancer binding protein; E1A-associated protein p300; E1A-binding protein, 300kD; EP300: E1A binding protein p300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; p300 HAT; Protein propionyltransferase p300; RB and P300 binding protein EID 1
Gene Aliases: A430090G16; A730011L11; EP300; KAT3B; P300; p300 HAT; RSTS2