This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Suggested positive control: HeLa nuclear extract.
p300 is a relatively stable, ubiquitously expressed, nuclear phosphoprotein which is conserved among a variety of mammalian species. It is actively synthesized and phosphorylated in both quiescent and proliferating cells.
Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of HAT activity, it has been suggested CBP and p300 may play a direct role in activating chromatin for transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cyclic AMP responsive enhancer binding protein; E1A-associated protein p300; E1A-binding protein, 300kD; EP300: E1A binding protein p300; histone acetyltransferase p300; p300 HAT; RB and P300 binding protein EID 1
Gene Aliases: A430090G16; A730011L11; KAT3B; p300; p300 HAT; RSTS2