Proteintech

p38 MAPK Monoclonal Antibody (1A1C2)

p38 MAPK Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

p38 MAPK Antibody (66234-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66234-1-Ig (p38 MAPK Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

66234-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:6,000

View 41 publications 41 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Pig

Published species

Mouse, Pig

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1A1C2

Immunogen

p38 MAPK Fusion Protein Ag5797 (1-307 aa encoded by BC031574)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.33 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSQERPTFY RQELNKTIWE VPERYQNLSP VGSGAYGSVC AAFDTKTGLR VAVKKLSRPF QSIIHAKRTY RELRLLKHMK HENVIGLLDV FTPARSLEEF NDVYLVTHLM GADLNNIVKC QKLTDDHVQF LIYQILRGLK YIHSADIIHR DLKPSNLAVN EDCELKILDF GLARHTDDEM TGYVATRWYR APEIMLNWMH YNQTVDIWSV GCIMAELLTG RTLFPGTDHI DQLKLILRLV GTPGAELLKK ISSESARNYI QSLTQMPKMN FANVFIGANP LAVDLLEKML VLDSDKRITA AQALAHAY (1-307 aa encoded by BC031574)

Target Information

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway.

Journal of ethnopharmacology

Li XC,Wang S,Yang XX,Li TJ,Gu JX,Zhao L,Bao YR,Meng XS

Mon Jun 12 00:00:00 UTC 2023

Anti-inflammatory effects of extracellular vesicles from Morchella on LPS-stimulated RAW264.7 cells via the ROS-mediated p38 MAPK signaling pathway.

Molecular and cellular biochemistry

Chen Q,Che C,Yang S,Ding P,Si M,Yang G

Wed Feb 01 00:00:00 UTC 2023

Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Tan R,You Q,Cui J,Wang M,Song N,An K,Lin L,Adu-Amankwaah J,Yuan J,Sun H

Sun Jan 01 00:00:00 UTC 2023

Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xian Z,Tian J,Zhao Y,Yi Y,Li C,Han J,Zhang Y,Wang Y,Wang L,Liu S,Pan C,Liu C,Wang D,Meng J,Tang X,Wang F,Liang A

Thu Jun 01 00:00:00 UTC 2023

Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.

Foods (Basel, Switzerland)

Zhao L,Miao Y,Shan B,Zhao C,Peng C,Gong J

Thu Mar 30 00:00:00 UTC 2023

LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.

Journal of experimental & clinical cancer research : CR

Wu T,Li X,Yan G,Tan Z,Zhao D,Liu S,Wang H,Xiang Y,Chen W,Lu H,Liao X,Li Y,Lu Z

Tue Jan 10 00:00:00 UTC 2023

HIV Tat-Conjugated Histone H3 Peptides Induce Tumor Cell Death Via Cellular Stress Responses.

Human gene therapy

Xu Q,Zhu F,Pan Y,Ren Y,Li J,Huang N,Liu K,Wang Y

Sun Jan 01 00:00:00 UTC 2023

Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.

Veterinary research

Wen Y,Chen Z,Tian Y,Yang M,Dong Q,Yang Y,Ding H

Thu Aug 04 00:00:00 UTC 2022

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.

Arthritis research & therapy

Yu H,Li M,Wen X,Yang J,Liang X,Li X,Bao X,Shu J,Ren X,Chen W,Li Z,Li Y

Fri Apr 29 00:00:00 UTC 2022

CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.

Pharmacological research

Pan G,Zhang J,Han Y,Chen Y,Guo X,Cui X,Cheng M,Gao H,Wang J,Jiang F

Tue Mar 01 00:00:00 UTC 2022

Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation.

Bioengineered

Yu Y,Wang M,Yu X,Yan Y,Yu B,Zhang D

Fri Apr 01 00:00:00 UTC 2022

Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Tang Y,Wang H,Nie K,Gao Y,Su H,Wang Z,Lu F,Huang W,Dong H

Thu Sep 01 00:00:00 UTC 2022

Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.

Journal of periodontal research

Cai J,Liu J,Yan J,Lu X,Wang X,Li S,Mustafa K,Wang H,Xue Y,Mustafa M,Kantarci A,Xing Z

Sat Oct 01 00:00:00 UTC 2022

Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.

Metabolic brain disease

Li F,Mao Q,Wang J,Zhang X,Lv X,Wu B,Yan T,Jia Y

Thu Dec 01 00:00:00 UTC 2022

Hypotonic induction of aquaporin5 expression in rat astrocytes through p38 MAPK pathway.

Anatomia, histologia, embryologia

Yi Y,Qiu G,Liu H,Gao F,Liu X,Chen Y,Yang M

Tue Nov 01 00:00:00 UTC 2022

ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Journal of hazardous materials

Li S,Ma Y,Ye S,Hu D,Xiao F

Wed Jan 05 00:00:00 UTC 2022

γ-mangostin attenuates amyloid-β42-induced neuroinflammation and oxidative stress in microglia-like BV2 cells via the mitogen-activated protein kinases signaling pathway.

European journal of pharmacology

Kong C,Jia L,Jia J

Tue Feb 15 00:00:00 UTC 2022

Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.

Heliyon

Huang X,Jiang L,Wen Z,Yuan M,Zhong Y

Tue Nov 01 00:00:00 UTC 2022

Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin.

Frontiers in pharmacology

Qi YS,Xiao MY,Xie P,Xie JB,Guo M,Li FF,Piao XL

Thu Dec 22 00:00:00 UTC 2022

Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhou H,Zhuang W,Huang H,Ma N,Lei J,Jin G,Wu S,Zhou S,Zhao X,Lan L,Xia H,Shangguan F

Thu Dec 01 00:00:00 UTC 2022

Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H₂O₂.

Molecules (Basel, Switzerland)

Zhou N,Tian Y,Wu H,Cao Y,Li R,Zou K,Xu W,Lu L

Tue May 31 00:00:00 UTC 2022

Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection.

Pharmacological research

Chen S,Lv K,Sharda A,Deng J,Zeng W,Zhang C,Hu Q,Jin P,Yao G,Xu X,Ming Z,Fang C

Sat May 01 00:00:00 UTC 2021

The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD.

Frontiers in pharmacology

Li J,Zhao P,Tian Y,Li K,Zhang L,Guan Q,Mei X,Qin Y

Wed Nov 17 00:00:00 UTC 2021

A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.

Food science & nutrition

Zhou S,Zhou Y,Yu J,Jiang L,Xiang Y,Wang J,Du Y,Cui X,Ge F

Thu Jul 01 00:00:00 UTC 2021

A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus.

International immunopharmacology

Min L,Wu Y,Cao G,Mi D,Chen C

Wed Sep 01 00:00:00 UTC 2021

Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.

The Journal of biological chemistry

He X,Gao F,Hou J,Li T,Tan J,Wang C,Liu X,Wang M,Liu H,Chen Y,Yu Z,Yang M

Sun Aug 01 00:00:00 UTC 2021

Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.

Experimental and therapeutic medicine

Wang C,Wang X,Han A,Wang Y,Jiang H

Sat May 01 00:00:00 UTC 2021

Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.

Toxicology and applied pharmacology

Wang X,Gong Q,Song C,Fang J,Yang Y,Liang X,Huang X,Liu J

Sat May 01 00:00:00 UTC 2021

Shikonin Induced Program Cell Death through Generation of Reactive Oxygen Species in Renal Cancer Cells.

Antioxidants (Basel, Switzerland)

Tsai MF,Chen SM,Ong AZ,Chung YH,Chen PN,Hsieh YH,Kang YT,Hsu LS

Thu Nov 18 00:00:00 UTC 2021

FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.

Development (Cambridge, England)

Li C,Liu Z,Wu G,Zang Z,Zhang JQ,Li X,Tao J,Shen M,Liu H

Thu Jul 15 00:00:00 UTC 2021

Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.

Redox report : communications in free radical research

Meng Q,Zaharieva EK,Sasatani M,Kobayashi J

Wed Dec 01 00:00:00 UTC 2021

Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension.

Frontiers in physiology

Zhao Z,Guo Z,Yin Z,Qiu Y,Zhou B

Tue Dec 28 00:00:00 UTC 2021

LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.

American journal of cancer research

Li Z,Zhou Z,Wu X,Zhou Q,Liao C,Liu Y,Li D,Shen L,Feng D,Yang L

Mon Sep 28 00:00:00 UTC 2020

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Oncology research

Wei W,Ma XD,Jiang GM,Shi B,Zhong W,Sun CL,Zhao L,Hou YJ,Wang H

Tue Sep 01 00:00:00 UTC 2020

Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.

Frontiers in pharmacology

Xu Q,Fan Y,Loor JJ,Liang Y,Sun X,Jia H,Zhao C,Xu C

Thu Dec 31 00:00:00 UTC 2020

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling.

Molecular medicine reports

Tang T,Wang LX,Yang ML,Zhang RM

Tue Dec 01 00:00:00 UTC 2020

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling.

Molecular medicine reports

Tang T,Wang LX,Yang ML,Zhang RM

Tue Dec 01 00:00:00 UTC 2020

Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis.

International journal of general medicine

Zhang S,Liu J,Yuan T,Liu H,Wan C,Le Y

Tue Apr 19 00:00:00 UTC 2022

Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells.

Cancer medicine

Zhao Z,Liu K,Tian X,Sun M,Wei N,Zhu X,Yang H,Wang T,Jiang G,Chen K

Mon Jul 01 00:00:00 UTC 2019

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca²⁺-dependent PKC/p38MAPK/NF-κB pathway.

Journal of neuroinflammation

Liu Q,Zhang Y,Liu S,Liu Y,Yang X,Liu G,Shimizu T,Ikenaka K,Fan K,Ma J

Wed Jan 16 00:00:00 UTC 2019

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.

Free radical biology & medicine

Wu W,Wang S,Liu Q,Wang X,Shan T,Wang Y

Sat Dec 01 00:00:00 UTC 2018

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.

Free radical biology & medicine

Wu W,Wang S,Liu Q,Wang X,Shan T,Wang Y

Sat Dec 01 00:00:00 UTC 2018

Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

Toxicology letters

Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

Mon Oct 15 00:00:00 UTC 2018

Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

Toxicology letters

Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

Mon Oct 15 00:00:00 UTC 2018

Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway.

Molecular medicine reports

Ma M,Yang X,Zhao L,Liu L,Zhang C,Wang X,Shan B

Sun Oct 01 00:00:00 UTC 2017

Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway.

Molecular medicine reports

Ma M,Yang X,Zhao L,Liu L,Zhang C,Wang X,Shan B

Sun Oct 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; SAPK2a; Stress-activated protein kinase 2a

View more View less

Gene Aliases: CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A

View more View less

UniProt ID: (Human) Q16539

View more View less

Entrez Gene ID: (Human) 1432, (Pig) 100156630

View more View less

Function(s)

protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding protein C-terminus binding enzyme binding protein phosphatase binding NFAT protein binding non-receptor serine/threonine protein kinase

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

p38 MAPK Monoclonal Antibody (1A1C2)

p38 MAPK Antibody (66234-1-IG) in IHC (P)

Product Details

66234-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!