Proteintech

p38 MAPK Monoclonal Antibody (1A1C2)

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Antibody Testing Data (10)

p38 MAPK Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 10

p38 MAPK Antibody (66234-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 66234-1-Ig (p38 MAPK Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

p38 MAPK Antibody in Western Blot (WB) — Human heart tissue were subjected to SDS PAGE followed by western blot with 66234-1-IG ( p38 MAPK Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

Product Details

66234-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:6,000

View 41 publications 41 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Pig

Published species

Mouse, Pig

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1A1C2

Immunogen

p38 MAPK Fusion Protein Ag5797 (1-307 aa encoded by BC031574)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1.33 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MSQERPTFY RQELNKTIWE VPERYQNLSP VGSGAYGSVC AAFDTKTGLR VAVKKLSRPF QSIIHAKRTY RELRLLKHMK HENVIGLLDV FTPARSLEEF NDVYLVTHLM GADLNNIVKC QKLTDDHVQF LIYQILRGLK YIHSADIIHR DLKPSNLAVN EDCELKILDF GLARHTDDEM TGYVATRWYR APEIMLNWMH YNQTVDIWSV GCIMAELLTG RTLFPGTDHI DQLKLILRLV GTPGAELLKK ISSESARNYI QSLTQMPKMN FANVFIGANP LAVDLLEKML VLDSDKRITA AQALAHAY (1-307 aa encoded by BC031574)

Target Information

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; SAPK2a; Stress-activated protein kinase 2a

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Gene Aliases: CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A

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UniProt ID: (Human) Q16539

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Entrez Gene ID: (Human) 1432, (Pig) 100156630

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Molecular Function: non-receptor serine/threonine protein kinase

Function(s)

Process(es)

protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding protein C-terminus binding enzyme binding protein phosphatase binding NFAT protein binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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p38 MAPK Monoclonal Antibody (1A1C2)

p38 MAPK Antibody (66234-1-IG) in IHC (P)

Product Details

66234-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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