|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||1:500|
|Western Blot (WB)||See 3 publications below|
|Immunoprecipitation (IP)||See 3 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Hamster, Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Human , Mouse|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||SV40-transformed mouse B4 cells|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-12453 targets p53 in FACS, IF, IP, and WB applications and shows reactivity with Hamster, Human, mouse, Non-human primate, and Rat samples.
The MA5-12453 immunogen is sV40-transformed mouse B4 cells.
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen NY-CO-13; Cellular tumor antigen p53; mutant p53; mutant tumor protein 53; p53 cellular tumor antigen; p53 tumor suppressor; Phosphoprotein p53; TP53; transformation related protein 53; transformation-related protein 53; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); Tumor suppressor p53; tumor supressor p53
Gene Aliases: bbl; BCC7; bfy; bhy; I79_002739; LFS1; p44; P53; TP53; TRP53
Molecular Function: transcription factor
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