Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||SV40 - transformed cell line BALBc SVA31E7 (1).|
|Storage buffer||PBS, pH 7.2|
|Contains||10mM sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cellular tumor antigen p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53
bbl; bfy; bhy; p44; p53; Tp53
Nucleoside, nucleotide and nucleic acid metabolism DNA metabolism DNA repair DNA recombination mRNA transcription Immunity and defense Stress response Oncogenesis Tumor suppressor Cell cycle Cell cycle control Apoptosis Induction of apoptosis