|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||SV40 - transformed cell line BALBc SVA31E7 (1).|
|Storage buffer||PBS, pH 7.2|
|Contains||10mM sodium azide|
|Storage conditions||4°C or -20°C if preferred|
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons
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Protein Aliases: cellular tumor antigen p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53
Gene Aliases: bbl; bfy; bhy; p44; p53; Tp53
UniProt ID: (Mouse) P02340
Entrez Gene ID: (Mouse) 22059
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