PA1-26615 detects cyclin-dependent kinase inhibitor 1C (p57, Kip2) from human, mouse, and bovine samples.
PA1-26615 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-26615 immunogen is a synthetic peptide corresponding to a portion of human CDKN1C.
The protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; p57 Kip2; p57Kip2
Gene Aliases: AL024410; BOS_25086; BWCR; BWS; CDKI; CDKN1C; KIP2; p57; p57(kip2); p57Kip2; WBS