Proteintech

smooth muscle actin Monoclonal Antibody (1E9A11)

smooth muscle actin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

smooth muscle actin Antibody (67735-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed C2C12 cells using smooth muscle actin specific antibody (Product # 67735-1-Ig) (Clone: 1E9A11) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

smooth muscle actin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

smooth muscle actin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

67735-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50,000

View 29 publications 29 publications

Immunohistochemistry (IHC)

View 18 publications 18 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:5,000

Immunocytochemistry (ICC/IF)

1:400

View 29 publications 29 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse, Rat, Zebrafish

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1E9A11

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle. Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands. Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6. Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. Multiple alternatively spliced variants of smooth muscle actin have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang Y,Ji H,Qiao O,Li Z,Pecoraro L,Zhang X,Han X,Wang W,Zhang X,Man S,Wang J,Li X,Liu C,Huang L,Gao W

Thu Jul 01 00:00:00 UTC 2021

Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang Y,Ji H,Qiao O,Li Z,Pecoraro L,Zhang X,Han X,Wang W,Zhang X,Man S,Wang J,Li X,Liu C,Huang L,Gao W

Thu Jul 01 00:00:00 UTC 2021

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.

Frontiers in molecular biosciences

Xue Y,Zhou Y,Bao W,Fu Q,Hao H,Han L,Zhang X,Tian X,Zhang M

Fri Nov 12 00:00:00 UTC 2021

USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro.

Plastic and reconstructive surgery

Tu L,Lin Z,Huang Q,Liu D

Mon Nov 01 00:00:00 UTC 2021

Inhibition of Neovascularization and Inflammation in a Mouse Model of Corneal Alkali Burns Using Cationic Liposomal Tacrolimus.

Frontiers in bioengineering and biotechnology

Lin X,Yu X,Chen X,Sheng S,Wang J,Wang B,Xu W

Sat Dec 25 00:00:00 UTC 2021

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling.

Frontiers in cell and developmental biology

Liu JT,Bao H,Fan YJ,Li ZT,Yao QP,Han Y,Zhang ML,Jiang ZL,Qi YX

Tue Oct 05 00:00:00 UTC 2021

Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.

Journal of ethnopharmacology

Zhou S,He Y,Zhang W,Xiong Y,Jiang L,Wang J,Cui X,Qu Y,Ge F

Tue Aug 10 00:00:00 UTC 2021

1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway.

International immunopharmacology

Yu B,Jin XQ,Yu WY,Dong YY,Ying HZ,Yu CH

Wed Dec 01 00:00:00 UTC 2021

1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway.

International immunopharmacology

Yu B,Jin XQ,Yu WY,Dong YY,Ying HZ,Yu CH

Wed Dec 01 00:00:00 UTC 2021

Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice.

The American journal of pathology

Meng L,Goto M,Tanaka H,Kamikokura Y,Fujii Y,Okada Y,Furukawa H,Nishikawa Y

Wed Sep 01 00:00:00 UTC 2021

Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice.

The American journal of pathology

Meng L,Goto M,Tanaka H,Kamikokura Y,Fujii Y,Okada Y,Furukawa H,Nishikawa Y

Wed Sep 01 00:00:00 UTC 2021

PEGylated gold nanorods are not cytotoxic to human endothelial cells but affect kruppel-like factor signaling pathway.

Toxicology and applied pharmacology

Li X,Tang Y,Chen C,Qiu D,Cao Y

Fri Nov 01 00:00:00 UTC 2019

MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1.

Stem cell research

Jin M,Wu Y,Wang Y,Yu D,Yang M,Yang F,Feng C,Chen T

Thu Sep 01 00:00:00 UTC 2016

MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1.

Stem cell research

Jin M,Wu Y,Wang Y,Yu D,Yang M,Yang F,Feng C,Chen T

Thu Sep 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Actin Alpha 2 Smooth Muscle Aorta; Actin Vascular Smooth Muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; Alpha Cardiac Actin; Alpha-actin-2; alpha-cardiac actin; Aortic Smooth Muscle; asma; Cell growth-inhibiting gene 46 protein; Growth Inhibiting Gene 46; smooth muscle; smooth muscle alpha-actin; vascular smooth muscle alpha-actin

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Gene Aliases: 0610041G09Rik; a-SMA; AAT6; ACT-4; ACTA2; actin; ACTSA; ACTVS; alphaSMA; GIG46; MYMY5; SMalphaA

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UniProt ID: (Human) P62736, (Rat) P62738, (Mouse) P62737

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Entrez Gene ID: (Pig) 733615, (Human) 59, (Rat) 81633, (Mouse) 11475

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Function(s)

ATP binding protein kinase binding nucleotide binding protein binding actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein

Process(es)

muscle contraction regulation of blood pressure response to virus positive regulation of gene expression vascular smooth muscle contraction glomerular mesangial cell development mesenchyme migration

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smooth muscle actin Monoclonal Antibody (1E9A11)

smooth muscle actin Antibody (67735-1-IG) in ICC/IF

Product Details

67735-1-IG

Western Blot (WB)

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Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

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