Lamin A and C are A-type lamins that arise from alternative splicing of the LMNA gene. As part of the lamin class of nuclear intermediate filament proteins, lamin A and C are major structural components of the matrix on the inner surface of the nuclear envelope.
During mitosis, lamin proteins are phosphorylated, resulting in the reversible disassembly of the lamina matrix. Lamins are also involved in chromatin structure, gene expression, nuclear stability, and apoptosis. Because they are ubiquitously expressed nuclear proteins, lamin A and C are useful as loading controls.
Mutations in lamin A and C have been linked to several human diseases including Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy, limb-girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
A variety of quality Invitrogen lamin A/C antibodies are available for your research, and most have been extensively validated for western blotting and immunostaining controls.