Seminar
Jul 29, 2018 - Aug 02, 2018
Washington Marriott Wardman Park | 2660 Woodley Rd NW - Washington, D.C.
HPLC 2018

HPLC 2018 is a memory but you can still access information about the products we exhibited at the conference and view our technical posters. We hope to see you at HPLC 2019 in Milan.

We introduced two new products at the conference to help improve your chromatography:

Posters

P-M-0100 – Sample Preparation

P-M-0300 – Characterization of Monoclonal Antibodies/Drug Conjugates/Protein-based Drugs

P-M-0600 – Foods/Beverages and Nutrition

P-T-0800 – Protein Characterization and Modification

P-T-0900 – Omics (metabolomics/lipidomics/glycomics/proteomics/genomics)

P-T-1000 – Method Development and Automation

P-T-1400 – Instrument Design and Applications

P-W-1600 – Forensics/Toxicology/Drugs of Abuse

  • P-W-1609: Tailoring Solvent Purity for Liquid Phase Separation Analysis

P-W-1700 – Biopharmaceutical and Pharmaceutical Applications

Products

Discover the unique ProPac WCX weak cation exchange (WCX) column designed for protein characterization including therapeutic proteins, monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), biosimilars and their charge variants.

Resources


Pharmaceutical scientists can now have confidence in the results gained from the ultra-trace analysis of critical polar N-containing compounds due to the ultra-low absorption surface. New inert glass vial is constructed of 1st hydrolytic class special 33 expansion glass to meet strict USPs and Pharmacopeias.

Resources


Three workflows. Two flow paths. One integrated UHPLC solution. Improve your productivity and sample knowledge for a faster return on investment.

Resources


The Q Exactive HF-X MS rises to the occasion and sets new standards in sensitivity, performance, and productivity.

Resources


Allows any chromatographer to easily access mass spectrometry with a system that has unmatched low mass sensitivity, is simple-to-use and robust.

Resources


Separate your science from the status quo. Experience uncompromised UHPLC—with no trade-offs in performance, robustness and ease of use.

Resources


Make the invisible visible with a versatile, universal detector that adds a unique form of detection to the speed and resolution of your UPHLC system.

Resources


With the ability to use 4-μm particle size IC columns on high-pressure capable IC systems, you can finally choose between achieving even faster run times or better chromatographic resolution.

Resources


The Thermo Scientific nano and capillary systems are ideal for use as an integrated part of the proteomics workflow and seamlessly combine with our mass spectrometry systems

Resources


Our extensive family of products includes a variety of particle sizes and column designs to meet all separation needs, offering improved resolution, enhanced sensitivity, faster analysis and consistent performance.

Resources


From microsampling to headspace applications, you'll find the right vials and closures to match your application and autosampler requirements from our comprehensive portfolio.

Resources


Simplify your lab workflow with unified control, processing and data management for your chromatography/mass spectrometry instruments.

Resources


For all HPLC/UHPLC and LC-MS applications, each Fisher Chemical high-quality solvent undergoes rigorous quality assurance and testing measures.


Deliver robust reproducible gradients with the Thermo Scientific pH buffer platform that is applicable to a wide range of mAbs and ready to use with existing LC columns and systems, without the need to formulate mobile phases.

Lunchtime seminars

Effectively Supporting Synthetic Chemistry for Pharmaceutical and Academic Research

Monday, July 30, 12:25 – 1:25 p.m.
Jenny Wong, HPLC Product Marketing Specialist, Thermo Fisher Scientific

Monitoring the synthesis of small or larger molecules is a key activity in pharmaceutical but also academic research. The investigation of new structural entities and compounds often requires re-creation of the characterized novel structures to conduct further general research or identify therapeutic properties. This workshop will showcase our comprehensive new workflow solution discussing not only fast mass confirmation, but also how to produce better mass balances of unknown impurities and non-chromophores. In addition, we discuss advanced system configurations multiplying detection options as well as productivity of multi-detector UHPLC setups.

Simple Approaches to Charge Variant Analysis

Tuesday, July 31, 12:25 – 1:25 p.m.
Jonathan Bones, Principal Investigator, NIBRT Characterization and Comparability Laboratory, NIBRT

The characterization of monoclonal antibodies (mAbs) during biopharmaceutical development involves the identification, monitoring, and analysis of charge variants. Antibodies can exhibit changes in charge heterogeneity during production and purification caused by amino acid substitutions, glycosylation, and other post-translational or chemical modifications. Not only can these changes impact stability and activity, they can also cause adverse immunological reactions. Identification of charge variants in development, and their monitoring throughout manufacturing is therefore critical. In this presentation the use of ion exchange and reverse phase approaches is discussed along with enabling technologies that simplify analysis.

Oral presentations

Tuesday
1:30 p.m. (L-092)
Parallel Session: Glycomics – I

Keynote Lecture: High pH Anion Exchange Separation of Carbohydrates: Past, Present and Future
Christopher Pohl, Thermo Fisher Scientific (recipient of the 2018 Uwe D. Neue Award in Separation Science)

2:35 p.m. (L-091)
Parallel Session: Quality by Design

Algorithmic Approach to LC-MS and IC-MS Method Development and Optimization of the ESI Ion Source Settings
Alexander Semyonov, Thermo Fisher Scientific

Wednesday
11:45 a.m. (L-132)

Parallel Session: Advances in Liquid Chromatography – III
Complementary Parallel LC as a Convenient Alternative to Multi Heart-Cut LC for Samples of Medium Complexity
Maria Gruebner, Mauro De Pra, Frank Steiner, Thermo Fisher Scientific

Posters

P-M-0100 – Sample Preparation

P-M-0300 – Characterization of Monoclonal Antibodies/Drug Conjugates/Protein-based Drugs

P-M-0600 – Foods/Beverages and Nutrition

P-T-0800 – Protein Characterization and Modification

P-T-0900 – Omics (metabolomics/lipidomics/glycomics/proteomics/genomics)

P-T-1000 – Method Development and Automation

P-T-1400 – Instrument Design and Applications

P-W-1600 – Forensics/Toxicology/Drugs of Abuse

  • P-W-1609: Tailoring Solvent Purity for Liquid Phase Separation Analysis

P-W-1700 – Biopharmaceutical and Pharmaceutical Applications

Products

Discover the unique ProPac WCX weak cation exchange (WCX) column designed for protein characterization including therapeutic proteins, monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), biosimilars and their charge variants.

Resources


Pharmaceutical scientists can now have confidence in the results gained from the ultra-trace analysis of critical polar N-containing compounds due to the ultra-low absorption surface. New inert glass vial is constructed of 1st hydrolytic class special 33 expansion glass to meet strict USPs and Pharmacopeias.

Resources


Three workflows. Two flow paths. One integrated UHPLC solution. Improve your productivity and sample knowledge for a faster return on investment.

Resources


The Q Exactive HF-X MS rises to the occasion and sets new standards in sensitivity, performance, and productivity.

Resources


Allows any chromatographer to easily access mass spectrometry with a system that has unmatched low mass sensitivity, is simple-to-use and robust.

Resources


Separate your science from the status quo. Experience uncompromised UHPLC—with no trade-offs in performance, robustness and ease of use.

Resources


Make the invisible visible with a versatile, universal detector that adds a unique form of detection to the speed and resolution of your UPHLC system.

Resources


With the ability to use 4-μm particle size IC columns on high-pressure capable IC systems, you can finally choose between achieving even faster run times or better chromatographic resolution.

Resources


The Thermo Scientific nano and capillary systems are ideal for use as an integrated part of the proteomics workflow and seamlessly combine with our mass spectrometry systems

Resources


Our extensive family of products includes a variety of particle sizes and column designs to meet all separation needs, offering improved resolution, enhanced sensitivity, faster analysis and consistent performance.

Resources


From microsampling to headspace applications, you'll find the right vials and closures to match your application and autosampler requirements from our comprehensive portfolio.

Resources


Simplify your lab workflow with unified control, processing and data management for your chromatography/mass spectrometry instruments.

Resources


For all HPLC/UHPLC and LC-MS applications, each Fisher Chemical high-quality solvent undergoes rigorous quality assurance and testing measures.


Deliver robust reproducible gradients with the Thermo Scientific pH buffer platform that is applicable to a wide range of mAbs and ready to use with existing LC columns and systems, without the need to formulate mobile phases.

Lunchtime seminars

Effectively Supporting Synthetic Chemistry for Pharmaceutical and Academic Research

Monday, July 30, 12:25 – 1:25 p.m.
Jenny Wong, HPLC Product Marketing Specialist, Thermo Fisher Scientific

Monitoring the synthesis of small or larger molecules is a key activity in pharmaceutical but also academic research. The investigation of new structural entities and compounds often requires re-creation of the characterized novel structures to conduct further general research or identify therapeutic properties. This workshop will showcase our comprehensive new workflow solution discussing not only fast mass confirmation, but also how to produce better mass balances of unknown impurities and non-chromophores. In addition, we discuss advanced system configurations multiplying detection options as well as productivity of multi-detector UHPLC setups.

Simple Approaches to Charge Variant Analysis

Tuesday, July 31, 12:25 – 1:25 p.m.
Jonathan Bones, Principal Investigator, NIBRT Characterization and Comparability Laboratory, NIBRT

The characterization of monoclonal antibodies (mAbs) during biopharmaceutical development involves the identification, monitoring, and analysis of charge variants. Antibodies can exhibit changes in charge heterogeneity during production and purification caused by amino acid substitutions, glycosylation, and other post-translational or chemical modifications. Not only can these changes impact stability and activity, they can also cause adverse immunological reactions. Identification of charge variants in development, and their monitoring throughout manufacturing is therefore critical. In this presentation the use of ion exchange and reverse phase approaches is discussed along with enabling technologies that simplify analysis.

Oral presentations

Tuesday
1:30 p.m. (L-092)
Parallel Session: Glycomics – I

Keynote Lecture: High pH Anion Exchange Separation of Carbohydrates: Past, Present and Future
Christopher Pohl, Thermo Fisher Scientific (recipient of the 2018 Uwe D. Neue Award in Separation Science)

2:35 p.m. (L-091)
Parallel Session: Quality by Design

Algorithmic Approach to LC-MS and IC-MS Method Development and Optimization of the ESI Ion Source Settings
Alexander Semyonov, Thermo Fisher Scientific

Wednesday
11:45 a.m. (L-132)

Parallel Session: Advances in Liquid Chromatography – III
Complementary Parallel LC as a Convenient Alternative to Multi Heart-Cut LC for Samples of Medium Complexity
Maria Gruebner, Mauro De Pra, Frank Steiner, Thermo Fisher Scientific