T cell activation

T cell activation requires at least two signals to become fully activated. The first occurs after engagement of the T cell antigen-specific receptor (TCR) by the antigen-major histocompatibility complex (MHC), and the second by subsequent engagement of co-stimulatory molecules. The most potent T cell co-stimulator is CD28. These signals are transmitted to the nucleus and result in:

  1. Clonal expansion of T cells
  2. Upregulation of activation markers on the cell surface
  3. Differentiation into effector cells
  4. Induction of cytotoxicity or cytokine secretion
  5. Induction of apoptosis

 T Cell Activation Protocol, In Vitro

T Cell Activation

Additional information