HeavyPeptide AQUA Custom Peptide Synthesis Service

Thermo Scientific HeavyPeptide AQUA Custom Synthesis Service provides isotopically labeled, AQUA-grade peptides for the relative and absolute quantitation of proteins at very low concentrations in complex protein mixtures. Peptides are synthesized using the latest Fmoc solid-phase technology and purified by HPLC. All HeavyPeptide sequences come with mass spectrometric analysis, and AQUA Ultimate and QuantPro-grade peptides also come with analytical HPLC data. Additionally, we offer a wide range of labels, modifications, scales, and purities.

  • Quality—synthesized using pure materials and packaged using ArgonGuard
  • Accuracy—concentration precision for reproducible results
  • Sensitivity—provides for the absolute quantification of low-abundance proteins
  • Specificity—Up to 100% peptide sequence specificity
  • Flexibility—extensive list of available modifications, solvents, concentrations, and formats

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Compare HeavyPeptide AQUA-Grade Standards

  AQUA Ultimate AQUA QuantPro AQUA Basic
Formulation 5 pmol/µL in 5% (v/v) acetonitrile/H2O 5 pmol/µL in 5% (v/v) acetonitrile/H2O lyophilized
Concentration precision ±5% ±25%  
Peptide purity >97% >97% >95%
Isotopic enrichment >99% >99% >99%
Peptide length Up to 15 amino acids Up to 15 amino acids Up to 15 amino acids
Amount/aliquot number 10 nmol/10 aliquots
40 nmol/40 aliquots
96 nmol/96 aliquots
10 nmol/10 aliquots
40 nmol/40 aliquots
96 nmol/96 aliquots
15 to 30 nmol† (0.05 to 0.1mg)/1 aliquot
Shipment In solution on wet ice In solution on wet ice Dry at room temperature

†The 30 nmol scale is valid for peptides 6–15 amino acids in length. For shorter or longer peptides, the amount might decrease to as little as 15 nmol.

Product options

  • Additional light amino acids to extend the peptide length
  • Additional heavy amino acid on each peptide
  • Multiple solvents, concentrations and aliquot sizes available
  • Peptides delivered in various formats (e.g., 96-well plate with or without detachable tubes in glass or plastic, 2D barcodes, etc.)

Peptide modifications

  • Single or double phosphorylation (pY, pT or pS)
  • Cysteine carbamidomethylation (CAM)
  • Chloro-L-Tyrosine
  • Pryoglutamic acid
  • Methionine oxidation (Met[O])
  • Other modifications available on request
CAM tends to cause cyclisation at the N-terminus. Fully cyclized form can be provided upon request.


  • Biomarker discovery, verification and validation
  • Functional quantitative proteomics
  • Quantitation of post-translational modifications
  • Confirmation of RNA interference (RNAi)
  • Pharmacokinetics
  • Metabolomics
  • Clinical biochemistry for drug and metabolite monitoring
  • Anti-doping testing
  • Protein expression monitoring
  • Cell signal profiling and pathway validation
Heavy amino acids offered with Thermo Scientific HeavyPeptide Custom Synthesis†
Amino acid Code Mass difference Isotope Isotopic enrichment
Alanine A +4 Da U-13C3, 15N >99%
Arginine R +10 Da U-13C6, 15N4 >99%
Isoleucine I +7 Da U-13C6, 15N >99%
Leucine L +7 Da U-13C6, 15N >99%
Lysine K +8 Da U-13C6, 15N2 >99%
Phenylalanine F +10 Da U-13C9, 15N >99%
Proline P +6 Da U-13C5, 15N >99%
Valine V +6 Da U-13C5, 15N >99%

†Other amino acids on request.

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