Identify the right drug candidates

Identify the right drug candidates

Thermo Scientific™ twin-screw extruders are built with similar geometries. This enables experimentation and feasibility projects with a lab-scale (11 mm screw) extruder that minimizes the use of expensive APIs and enables easy clean-up between experiments. 

With a minimum throughput of 20 g/h, a benchtop extruder is ideal for Phase 1 research applications, especially when developing and testing recipes with expensive API and associated compounds. As a GMP-compliant unit, the Thermo Scientific™ Pharma 11 is also suitable for clinical trials and small-scale production for throughputs up to 2.5 kg/h. The screw and barrel designs are geometrically scalable across the whole Thermo Scientific portfolio of extruders from lab and pilot through to production scale.

For consistent, controllable processing of hot melt drug formulations that are suitable for PAT, the 24mm twin screw extruder promises reduced product changeover time, minimized scale-up risk and easy cleaning.

This platform includes a number of integrated ancillary equipment for both project development and small-scale production including pre-mixers, feeders, chill rolls, air-cooled conveyors, pelletizers, and cast sheet or blown film lines. GMP standard pharmaceutical versions of the ancillaries are available with stainless steel construction and dust-tight touch-screen operator interface.

Pharma Twin-Screw Extruders Micro-Compound 11mm TSE 16mm TSE
24mm TSE
Recommended for Feasibility Research  Phase 1 Pilot  Phase 2 Manufacturing  Phase 3
Typical Throughput Hot Melt Extrusion 3 g batch or 100 g/h 20 g/h – 2.5 kg/h 500 g/h – 5 kg/h 500 g/h – 20 kg/h
Typical Throughput Continuous Granulation N/A up to 3 kg/h up to 15 kg/h up to 60 kg/h
Dimensions
(L × W × H)
650 × 470 × 590mm 820 × 480 × 410mm 1750 × 610 × 1220mm 1900 × 800 × 1300mm
Downstream Options Take Off Belt Conveyor Belt Pelletizer Conveyor Belt Pelletizer Chill Roll Conveyor Belt Pelletizer Chill Roll
Suitable for Co-Extrusion Implant Production Co-Extrusion Sheet Extrusion Implant Production Co-Extrusion Sheet Extrusion Implant Production Sheet Extrusion High-Volume HME Production
Screw Design Conical,
Co-/Counter
Parallel, Co-Rotating Parallel, Co-Rotating Parallel, Co-Rotating
Max. Torque 5 Nm/shaft 6 Nm/shaft 18 Nm/shaft 52.5 Nm/shaft