{"id":1846,"date":"2026-05-25T01:26:35","date_gmt":"2026-05-25T01:26:35","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=1846"},"modified":"2026-05-25T01:26:36","modified_gmt":"2026-05-25T01:26:36","slug":"olink-gout","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/olink-gout\/","title":{"rendered":"\u4e2d\u56fd\u58f0\u97f3\uff5c\u5e7f\u4e1c\u4eba\u6c11\u533b\u9662\u56e2\u961f\u5229\u7528Olink\u86cb\u767d\u7ec4\u5b66\u63ed\u79d8\u75db\u98ce\u708e\u75c7\u7279\u5f81\u56fe\u8c31"},"content":{"rendered":"\n<p><strong>\u524d\u5f80<a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/brands\/olink-proteomics-protein-biomarker-analysis.html?icid=cn-blog-olink\" target=\"_blank\" rel=\"noreferrer noopener\">\u8d5b\u9ed8\u98deOlink\u4e3b\u9875<\/a>&gt;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u7814\u7a76\u80cc\u666f\"><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/h2>\n\n\n\n<p><strong>\u75db\u98ce<\/strong>\uff08Gout\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684<strong>\u5173\u8282\u708e\u6027\u75be\u75c5<\/strong>\uff0c\u5176\u7279\u5f81\u662f\u8840\u6e05\u5c3f\u9178\uff08SUA\uff09\u6c34\u5e73\u5347\u9ad8\uff0c\u5bfc\u81f4\u5355\u94a0\u5c3f\u9178\u76d0\uff08MSU\uff09\u6676\u4f53\u5728\u5173\u8282\u5185\u548c\u5173\u8282\u5468\u56f4\u6c89\u79ef\uff0c\u8fdb\u800c\u89e6\u53d1<strong>\u5148\u5929\u514d\u75ab\u53cd\u5e94<\/strong>\u3002\u8fd1\u5e74\u6765\uff0c\u5168\u7403\u8303\u56f4\u5185\u539f\u53d1\u6027\u75db\u98ce\u548c\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u53d1\u75c5\u7387\u5747\u5448\u4e0a\u5347\u548c<strong>\u5e74\u8f7b\u5316\u8d8b\u52bf<\/strong>\u3002\u5728\u4e2d\u56fd\uff0c\u75db\u98ce\u7684\u8c03\u6574\u60a3\u75c5\u7387\u4e3a3.2%\uff0c\u800c\u9ad8\u5c3f\u9178\u8840\u75c7\u7684\u6bd4\u4f8b\u9ad8\u8fbe17.7%\u3002<\/p>\n\n\n\n<p><strong>NLRP3\u708e\u75c7\u5c0f\u4f53<\/strong>\u662fMSU\u6676\u4f53\u5f15\u53d1\u7ec6\u80de\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\u7684\u6838\u5fc3\u3002\u4e00\u65e6\u6fc0\u6d3b\uff0c\u5c06\u4fc3\u8fdb<strong>\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50<\/strong>\u5206\u6ccc\uff0c\u5305\u62ec\u767d\u4ecb\u7d20-1\u03b2\uff08IL-1\u03b2\uff09\u548c\u767d\u4ecb\u7d20-18\uff08IL-18\uff09\u3002\u5176\u4e2d\uff0cIL-1\u03b2\u662f\u4ecb\u5bfc<strong>\u75db\u98ce\u7279\u5f81\u6027\u708e\u75c7\u7ea7\u8054\u53cd\u5e94<\/strong>\u7684\u5173\u952e\u56e0\u5b50\u3002\u5176\u5206\u6ccc\u542f\u52a8\u4e86\u5176\u5b83<strong>\u514d\u75ab\u7ec6\u80de<\/strong>\u7684\u52df\u96c6\uff0c\u5f15\u53d1\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\uff0c\u8868\u73b0\u4e3a\u75db\u98ce\u7684\u6807\u5fd7\u6027\u75c7\u72b6\uff0c\u5982\u5173\u8282\u5267\u70c8\u75bc\u75db\u3001\u7ea2\u80bf\u548c\u53d1\u70ed\u7b49\u3002<\/p>\n\n\n\n<p>\u5c3d\u7ba1NLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u6fc0\u6d3b\u88ab\u8ba4\u4e3a\u662f\u5173\u952e\u4e8b\u4ef6\uff0c\u4f46\u9a71\u52a8\u75db\u98ce\u7684\u786e\u5207\u673a\u5236\u4ecd\u672a\u5b8c\u5168\u9610\u660e\u3002\u76ee\u524d\u8ba4\u4e3a\uff0c<strong>\u591a\u79cd\u8c03\u8282\u9014\u5f84<\/strong>\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u4e86\u75db\u98ce\u708e\u75c7\u7684<strong>\u591a\u6837\u5316\u4e34\u5e8a\u8868\u73b0<\/strong>\u3002<strong>\u90bb\u4f4d\u5ef6\u4f38\u5206\u6790\u6280\u672f<\/strong>\uff08PEA\uff09\u4f5c\u4e3a\u4e00\u79cd\u524d\u6cbf\u7684\u86cb\u767d\u7ec4\u5b66\u65b9\u6cd5\uff0c\u80fd\u591f\u7cbe\u51c6\u6d4b\u91cf\u5fae\u91cf\u751f\u7269\u6db2\u4f53\u4e2d\u7684<strong>\u4f4e\u4e30\u5ea6\u86cb\u767d<\/strong>\uff0c\u7279\u522b\u9002\u7528\u4e8e<strong>\u514d\u75ab\u708e\u75c7\u56fe\u8c31<\/strong><strong>\u63cf\u7ed8<\/strong>\u548c\u708e\u6027\u75be\u75c5\u673a\u7406\u7814\u7a76\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u6587\u7ae0\u7b80\u4ecb\"><strong>\u6587\u7ae0\u7b80\u4ecb<\/strong><\/h2>\n\n\n\n<p><strong>\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u98ce\u6e7f\u514d\u75ab\u79d1\u674e\u5929\u65fa\u4e3b\u4efb<\/strong>\u56e2\u961f\u5229\u7528Olink Target 48 Cytokine Panel\uff0c\u63cf\u7ed8\u4e86\u75db\u98ce\u60a3\u8005\u8840\u6e05\u548c\u6ed1\u6db2\uff08SF\uff09\u7684<strong>\u708e\u75c7\u7279\u5f81\u56fe\u8c31<\/strong>\uff0c\u7814\u7a76\u7ed3\u679c\u8fd1\u671f\u53d1\u8868\u4e8e<em>Front Immunol<\/em>\u6742\u5fd7\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"787\" height=\"326\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u72479.png\" alt=\"\" class=\"wp-image-1847\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u72479.png 787w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u72479-300x124.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u72479-768x318.png 768w\" sizes=\"auto, (max-width: 787px) 100vw, 787px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u7814\u7a76\u89e3\u8bfb\"><strong>\u7814\u7a76\u89e3\u8bfb<\/strong><\/h2>\n\n\n\n<p>\u7814\u7a76\u6536\u96c6\u4e868\u540d\u75db\u98ce\u60a3\u8005\uff08GS\uff09\u30018\u540d\u9aa8\u5173\u8282\u708e\u60a3\u8005\uff08OS\uff09\u548c8\u540d\u5065\u5eb7\u5bf9\u7167\uff08HS\uff09\u7684\u8840\u6e05\u6837\u672c\uff0c\u4ee5\u53ca14\u540d\u75db\u98ce\u60a3\u8005\uff08GJ\uff09\u548c13\u540d\u9aa8\u5173\u8282\u708e\u60a3\u8005\uff08OJ\uff09\u7684<strong>\u6ed1\u6db2<\/strong>\uff08SF\uff09\u6837\u672c\u3002\u4f7f\u7528<strong>Olink Target 48 Cytokine Panel<\/strong>\u5bf9\u4ee5\u4e0a\u6837\u672c\u4e2d\u768445\u79cd\u86cb\u767d\u8fdb\u884c\u4e86\u68c0\u6d4b\uff0c\u5176\u4e2d\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u3001\u8d8b\u5316\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\u3002<\/p>\n\n\n\n<p><strong>\u8840\u6e05\u86cb\u767d\u4e3b\u6210\u5206\u5206\u6790<\/strong>\uff08PCA\uff09\u5c55\u793a\u4e86\u75db\u98ce\u3001\u9aa8\u5173\u8282\u708e\uff08OA\uff09\u548cHC\u4e2d\u4e0d\u540c\u7684\u805a\u7c7b\u6a21\u5f0f\uff08\u4e0b\u56feB\uff09\u3002\u5065\u5eb7\u5bf9\u7167\u8005\u7684\u86cb\u767d\u8d28\u8c31\u5177\u6709\u9ad8\u5ea6\u4e00\u81f4\u6027\uff0c\u800c<strong>\u75db\u98ce\u60a3\u8005\u8840\u6e05\u6837\u672c\u7684\u86cb\u767d\u56fe\u8c31\u5177\u6709\u663e\u8457\u5f02\u8d28\u6027<\/strong>\u3002SF\u86cb\u767dPCA\u5206\u6790\u663e\u793a<strong>\u75db\u98ce\u548cOA\u4e4b\u95f4\u5b58\u5728\u5927\u91cf\u91cd\u53e0<\/strong>\uff0c\u8868\u660e\u4e24\u7ec4\u95f4\u5177\u6709\u76f8\u4f3c\u7684\u86cb\u767d\u7ec4\u5b66\u7279\u5f81\uff08\u4e0b\u56feC\uff09\u3002\u70ed\u56fe\u663e\u793a\uff0cGS\u4e2d\u90e8\u5206\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u9ad8\u4e8eHS\uff08\u4e0b\u56feD\uff09\uff1bGJ\u548cHS\u7ec4\u95f4\u7684\u86cb\u767d\u6c34\u5e73\u4e5f\u6709\u663e\u8457\u5dee\u5f02\u3002\u5728\u6ed1\u6db2\u4e2d\uff0cGJ\u5e76\u6ca1\u6709\u663e\u793a\u51fa\u6bd4OJ\u66f4\u9ad8\u7684\u86cb\u767d\u8868\u8fbe\uff08\u4e0b\u56feE\uff09\uff0c\u8fd9\u4e5f\u4e0ePCA\u7684\u7ed3\u679c\u4e00\u81f4\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"729\" height=\"655\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724710.png\" alt=\"\" class=\"wp-image-1848\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724710.png 729w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724710-300x270.png 300w\" sizes=\"auto, (max-width: 729px) 100vw, 729px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u56fe1. \u75db\u98ce\u7684\u7efc\u5408\u86cb\u767d\u7ec4\u56fe\u8c31<\/p>\n\n\n\n<p>\u4e3a\u4e86\u9610\u660e\u75db\u98ce\u60a3\u8005\u4e2d<strong>\u708e\u75c7\u86cb\u767d\u8868\u8fbe\u6a21\u5f0f<\/strong>\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u4e0d\u540c\u7ec4\u522b\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u4e0eHS\u76f8\u6bd4\uff0c<strong>GS\u7ec4\u4e2d\u670920\u79cd\u86cb\u767d\u6c34\u5e73\u663e\u8457\u5347\u9ad8<\/strong>\uff08\u4e0b\u56feA\uff09\uff0c\u5305\u62ecIL-8\u3001 MCP-3\u3001IL-1b\u3001 IL-6\u3001 EGF\u3001 OSM\u3001LOX-1\u3001MIP-1a\u3001 MMP-1\u3001TGF-a\u3001VEGF-A\u3001MIP-1b\u3001 IL-7\u3001MMP-12\u3001MCP-2\u3001MCP-1\u3001GM-CSF\u3001IL-2\u3001HGF \u548c I-TAC\u3002\u5927\u90e8\u5206\u86cb\u767d\u5728OS\u7ec4\u4e2d\u7684\u8868\u8fbe\u4e5f\u663e\u8457\u9ad8\u4e8eHS\uff08\u4e0b\u56feB\uff09\u3002\u5728GJ\u548cOJ\u7684\u6bd4\u8f83\u4e2d\uff0c\u53d1\u73b0\u4e86GJ\u7ec4\u4e2dIL-8\u3001 IL-6\u3001IP-10\u3001 IL-17F\u3001MIP-3b\u548cVEGF-A\u6c34\u5e73\u7684\u5347\u9ad8\uff08\u4e0b\u56feC\uff09\u3002\u800cGJ\u4e0eGS\u7684\u6bd4\u8f83\u4e5f\u89c2\u5bdf\u5230\u4e86\u4e0d\u540c\u7684\u86cb\u767d\u8868\u8fbe\u6a21\u5f0f\uff08\u4e0b\u56feD\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"781\" height=\"518\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724711.png\" alt=\"\" class=\"wp-image-1849\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724711.png 781w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724711-300x199.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724711-768x509.png 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724711-96x65.png 96w\" sizes=\"auto, (max-width: 781px) 100vw, 781px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u56fe2. \u4e0d\u540c\u7ec4\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u706b\u5c71\u56fe<\/p>\n\n\n\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc4\u4f30\u68c0\u6d4b\u86cb\u767d\u5728\u533a\u5206<strong>\u75db\u98ce\u3001\u9aa8\u5173\u8282\u708e\u4e0e\u5065\u5eb7\u8005\u4e2d\u7684\u6709\u6548\u6027<\/strong>\uff0c\u7814\u7a76\u4eba\u5458\u9009\u62e9\u4e86\u5728GS\u548cGJ\u7ec4\u4e2d\u9ad8\u8868\u8fbe\u7684\u86cb\u767d\u8d28\uff0c\u8fdb\u884c<strong>ROC\u66f2\u7ebf\u5206\u6790<\/strong>\u3002\u5728\u8840\u6e05\u6837\u672c\u4e2d\uff0c\u4e0eOS\u548cHS\u76f8\u6bd4\uff0cGS\u7ec4\u7684\u9ad8\u8868\u8fbe\u6c34\u5e73\u86cb\u767d\uff0cVEGF-A\u3001MMP-1\u3001TGF-a\u548cOSM\uff0c\u5bf9\u5e94\u7684AUC\u5206\u522b\u4e3a0.95\uff0c0.95\uff0c0.92\u548c0.91\u3002\u5728\u6ed1\u6db2\u6837\u672c\u4e2d\uff0c\u4e0eOJ\u76f8\u6bd4\uff0cGJ\u4e2d\u7684\u9ad8\u8868\u8fbe\u86cb\u767d\u662fIP-10\u3001VEGF-A\u3001IL-8\u548cMIP-3b\uff0c\u5176\u5bf9\u5e94\u7684AUC\u4e3a0.78\u30010.78\u30010.76\u548c0.75\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u4eba\u5458\u901a\u8fc7<strong>STRING\u6784\u5efa\u4e86\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528<\/strong>\uff08PPI\uff09\u7f51\u7edc\uff0c\u4ee5\u6df1\u5165\u4e86\u89e3\u75db\u98ce\u4e2d\u86cb\u767d\u95f4\u529f\u80fd\u5173\u7cfb\u548c\u751f\u7269\u5b66\u610f\u4e49\u3002\u8f93\u5165\u5728GS\u7ec4\u4e2d\u7684\u9ad8\u8868\u8fbe\u86cb\u767d\uff08\u4e0eHS\u6bd4\uff09\uff0c\u5927\u591a\u6570\u86cb\u767d\u53c2\u4e0e\u5e76\u5f62\u6210\u4e86\u7d27\u5bc6\u4e92\u8054\u7684PPI\u7f51\u7edc\uff08\u4e0b\u56feA\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u53ea\u6709\u4e00\u4e2a\u86cb\u767d\u8d28\uff08MYDGF\uff09\u4e0d\u5728\u7f51\u7edc\u4e2d\u3002\u8be5\u7f51\u7edc\u4e2d\u8fb9\u7684\u6570\u91cf\u8d85\u8fc7\u4e86\u968f\u673a\u5173\u8054\u4e2d\u7684\u671f\u671b\u6570\u91cf\uff0c\u8868\u660e\u4e86<strong>\u86cb\u767d\u4ea4\u4e92\u6570\u91cf<\/strong>\u660e\u663e\u9ad8\u4e8e\u9884\u671f\u3002\u8fd9\u8868\u660e\u5927\u591a\u6570GS\u5dee\u5f02\u8868\u8fbe\u86cb\u767d\u53ef\u4ee5\u5728PPI\u7f51\u7edc\u4e2d\u6709\u6548\u76f8\u4e92\u4f5c\u7528\u3002\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86<strong>KEGG\u901a\u8def\u5bcc\u96c6\u5206\u6790<\/strong>\uff0c\u786e\u5b9a\u4e8653\u6761\u663e\u8457\u5bcc\u96c6\u7684\u901a\u8def\uff0c\u4e0b\u56feB\u663e\u793a\u4e86\u6700\u7a81\u51fa\u7684\u901a\u8def\uff0c\u5305\u62ec\u201c\u7ec6\u80de\u56e0\u5b50-\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u201d\u3001\u201c\u8d8b\u5316\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\u201d\u3001\u201cIL-17\u4fe1\u53f7\u901a\u8def\u201d\u3001\u201ctoll\u6837\u53d7\u4f53\u4fe1\u53f7\u901a\u8def\u201d\u3001\u201cJAK-STAT\u4fe1\u53f7\u901a\u8def\u201d\u548c\u201cPI3K-AKT\u4fe1\u53f7\u901a\u8def\u201d\u7b49\u5173\u952e\u8fc7\u7a0b\u3002\u8fd9\u4e9b\u663e\u8457\u5bcc\u96c6\u901a\u8def\u4e3a\u75db\u98ce\u7684\u6f5c\u5728\u751f\u7269\u5b66\u673a\u5236\u63d0\u4f9b\u4e86\u6709\u4ef7\u503c\u7684\u89c1\u89e3\u3002\u7814\u7a76\u56e2\u961f\u8fd8\u9488\u5bf9GJ\u4e2d\u7684\u9ad8\u8868\u8fbe\u86cb\u767d\u8d28\uff08\u4e0eOJ\u6bd4\uff09\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u8868\u660e\u4e86\u5dee\u5f02\u86cb\u767d\u8d28\u7684\u6709\u6548\u76f8\u4e92\u4f5c\u7528\uff08\u4e0b\u56feC\uff09\u548c\u663e\u8457\u901a\u8def\u5bcc\u96c6\uff08\u4e0b\u56feD\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"766\" height=\"467\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724712.png\" alt=\"\" class=\"wp-image-1850\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724712.png 766w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724712-300x183.png 300w\" sizes=\"auto, (max-width: 766px) 100vw, 766px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u56fe3. \u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u548c\u901a\u8def\u5bcc\u96c6\u5206\u6790<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u5199\u5728\u6700\u540e\"><strong>\u5199\u5728\u6700\u540e<\/strong><\/h2>\n\n\n\n<p><strong>\u86cb\u767d\u7ec4\u5b66\u6280\u672f<\/strong>\u5df2\u9010\u6b65\u5f97\u5230\u5e7f\u6cdb\u8ba4\u53ef\u548c\u5e94\u7528\uff0c\u4e0d\u4ec5\u4e3a\u6df1\u5165<strong>\u63a2\u7a76\u708e\u75c7\u6027\u75be\u75c5<\/strong>\u7684\u75c5\u7406\u751f\u7406\u673a\u5236\u63d0\u4f9b\u4e86\u5173\u952e\u89c1\u89e3\uff0c\u4e14\u5df2\u6210\u4e3a<strong>\u8bc6\u522b\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269<\/strong>\u7684\u91cd\u8981\u8d44\u6e90\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0cPEA\u6280\u672f\u501f\u52a9\u5176<strong>\u9ad8\u4fdd\u771f\u5ea6<\/strong>\u7684\u86cb\u767d\u5b9a\u91cf\u6570\u636e\uff0c\u6210\u529f\u63cf\u7ed8\u4e86\u75db\u98ce\u548c\u5173\u8282\u708e\u60a3\u8005\u8840\u6e05\u4e0e\u6ed1\u6db2\u6837\u672c\u7684<strong>\u708e\u75c7\u7279\u5f81\u56fe\u8c31<\/strong>\u3002\u8fd9\u4e00\u6280\u672f\u52a9\u529b\u7814\u7a76\u4eba\u5458\u8bc6\u522b\u51fa\u4e86VEGF-A\u3001MMP-1\u3001TGF-a\u548cOSM\u7b49<strong>\u75db\u98ce\u8bca\u65ad\u751f\u7269\u6807\u5fd7\u7269<\/strong>\u7684\u6709\u529b\u5019\u9009\u8005\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u9488\u5bf9<strong>\u6ed1\u6db2\u708e\u75c7\u86cb\u767d<\/strong><strong>\u5206\u6790<\/strong>\u63ed\u793a\u4e86\u75db\u98ce\u7684\u72ec\u7279\u6a21\u5f0f\uff0c\u663e\u793a\u4e86\u5176\u4e2dIP-10\u3001VEGF-A\u3001IL-8\u548cMIP-3b\u7684\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u5173\u8282\u708e\u60a3\u8005\u3002\u75db\u98ce\u60a3\u8005\u8840\u6e05\u548c\u6ed1\u6db2\u4e2d\u708e\u75c7\u86cb\u767d\u5347\u9ad8\u8868\u660e\u5b83\u4eec\u5728\u75be\u75c5\u76f8\u5173\u7684<strong>\u708e\u75c7\u8fc7\u7a0b<\/strong>\u548c<strong>\u7ec4\u7ec7\u635f\u4f24<\/strong>\u4e2d\u53d1\u6325\u7740\u4f5c\u7528\uff0c\u8fd9\u4f7f\u5f97\u8fd9\u4e9b\u86cb\u767d\u6807\u5fd7\u7269\u6709\u671b\u6210\u4e3a<strong>\u75db\u98ce\u65e9\u671f\u68c0\u6d4b<\/strong>\u548c<strong>\u75be\u75c5\u8fdb\u5c55\u76d1\u6d4b<\/strong>\u7684\u6807\u5fd7\u7269\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u8350\u9605\u8bfb<\/strong><\/p>\n\n\n\n<p><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=Mzg4ODU0NTQ5Nw==&amp;mid=2247490225&amp;idx=1&amp;sn=b1dc4b769ca7bab286fba90269bfafa7&amp;scene=21#wechat_redirect\" rel=\"noreferrer noopener\">\u75db\u98ce\u6848\u4f8b\uff5cOlink\u52a9\u529b\u7cfb\u7edf\u708e\u75c7\u56e0\u5b50\u56fe\u8c31\u7ed8\u5236\u4e0e\u65b0\u9776\u70b9\u53d1\u73b0<\/a><\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8d44\u6599\uff1a<\/strong><br>1.&nbsp;Huang Z,&nbsp;<em>et.al.<\/em>&nbsp;A targeted proteomics screen reveals serum and synovial fluid proteomic signature in patients with gout. Front Immunol. 2024 Nov 14;15:1468810.&nbsp;<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u5f80\u8d5b\u9ed8\u98deOlink\u4e3b\u9875&gt; \u7814\u7a76\u80cc\u666f 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