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\"\"<\/figure>\n\n\n\n

GSVA Z-score\u7bb1\u7ebf\u56fe<\/p>\n\n\n\n

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\u5728HS\u60a3\u8005\u4e2d\uff0cIHS4\u8bc4\u5206\u4e0eTh1\uff08IFNG\u3001CXCL9\u3001TNF\uff09\u3001Th2\uff08IL-4R\u3001IL-5\uff09\u3001Th17\uff08IL-17A\u3001IL-17F\u3001PI3\uff09\u4ee5\u53ca\u5fc3\u8840\u7ba1\/\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6807\u5fd7\u7269\uff08VEGFA\u3001AZU1\u3001PLAUR\uff09\u6b63\u76f8\u5173\u3002\u5728\u94f6\u5c51\u75c5\u60a3\u8005\u4e2d\uff0cPASI\u8bc4\u5206\u4e0e\u5148\u5929\/Th1\u514d\u75ab\u6807\u5fd7\u7269\uff08CXCL8\/IL-8\u3001CCL2\uff09\u3001Th17\uff08IL20RA\uff09\u3001\u5fc3\u8840\u7ba1\u98ce\u9669\u6807\u5fd7\u7269\uff08CCL7\u3001HDGF\uff09\u548cTh2\uff08CCL24\uff09\u663e\u8457\u76f8\u5173\u3002\u8fd9\u4e9b\u53d1\u73b0\u7a81\u51fa\u4e86\u8840\u6e05\u751f\u7269\u6807\u5fd7\u7269\u5931\u8c03\u4e0e\u75be\u75c5\u4e25\u91cd\u5ea6\u7684\u5e7f\u6cdb\u5173\u8054\uff0c\u652f\u6301\u4e86\u7cfb\u7edf\u6027\u514d\u75ab\u6fc0\u6d3b\u5728\u708e\u75c7\u6027\u76ae\u80a4\u75c5\u8fdb\u5c55\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5199\u5728\u6700\u540e<\/strong><\/h2>\n\n\n\n

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\u8be5\u7814\u7a76\u7684\u7ed3\u679c\u4e3a\u9488\u5bf9\u4e0d\u540c\u76ae\u80a4\u75c5\u514d\u75ab\u7279\u5f81\u7684\u7cbe\u51c6\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u76f4\u63a5\u4f9d\u636e\uff0c\u5e76\u63ed\u793a\u4e86\u5df2\u4e0a\u5e02\u53ca\u5728\u7814\u836f\u7269\u7684\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002\u7814\u7a76\u8868\u660e\uff0cHS\u7684\u75be\u75c5\u4e25\u91cd\u5ea6\u4e0e\u8840\u6e05IL-17A\u6c34\u5e73\u5448\u6b63\u76f8\u5173\uff0c\u8fd9\u4ece\u673a\u5236\u4e0a\u652f\u6301\u4e86\u6297IL-17A\u5355\u514b\u9686\u6297\u4f53\u53f8\u5e93\u5947\u5c24\u5355\u6297\uff08Secukinumab\uff09<\/strong> \u5728\u8be5\u75c5\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002\u6b64\u5916\uff0c\u7814\u7a76\u63d0\u793a\u9488\u5bf9Th17\u901a\u8def\u5176\u4ed6\u9776\u70b9\u7684\u836f\u7269\uff08\u5982\u6bd4\u7f8e\u5409\u73e0\u5355\u6297\uff08Bimekizumab\uff09\u3001\u5e03\u7f57\u5229\u5c24\u5355\u6297\uff08Brodalumab\uff09<\/strong> \u548c\u6297IL-36R\u836f\u7269\u53f8\u67cf\u7d22\u5229\u5355\u6297\uff08Spesolimab\uff09<\/strong>\u5728\u76f8\u5173\u75be\u75c5\u4e2d\u53ef\u80fd\u5177\u6709\u5e7f\u9614\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u540c\u65f6\uff0c\u7814\u7a76\u4e5f\u5370\u8bc1\u4e86JAK\u6291\u5236\u5242\uff0c\u5982\u5df4\u745e\u66ff\u5c3c\uff08Baricitinib\uff09\uff0c<\/strong> \u5728\u6591\u79c3\u4e2d\u7684\u5e94\u7528\u4e0e\u5728\u8c03\u8282\u591a\u7ec6\u80de\u56e0\u5b50\u901a\u8def\u65b9\u9762\u7684\u4ef7\u503c\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7814\u7a76\u53d1\u73b0\u5fc3\u8840\u7ba1\u98ce\u9669\u6807\u5fd7\u7269\uff08\u5982PDGFA\u5728HS\u4e2d\u4e0a\u8c03\uff09\u4e0e\u75be\u75c5\u4e25\u91cd\u5ea6\u5bc6\u5207\u76f8\u5173\uff0c\u8fd9\u5f3a\u8c03\u4e86\u5728\u6cbb\u7597\u76ae\u80a4\u708e\u75c7\u672c\u8eab\u7684\u540c\u65f6\uff0c\u9700\u91c7\u53d6\u7cfb\u7edf\u6027\u6cbb\u7597\u7b56\u7565\u4ee5\u76d1\u6d4b\u548c\u7ba1\u7406\u5176\u4f34\u968f\u7684\u5fc3\u8840\u7ba1\u4ee3\u8c22\u5e76\u53d1\u75c7\uff0c\u4ece\u800c\u5b9e\u73b0\u66f4\u5168\u9762\u7684\u75be\u75c5\u7ba1\u7406\u3002<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

1. Glickman JW, David E, Shokrian N, Hawkins K, Duca ED, Hu BD, Navrazhina K, Carroll B, Mishra A, Estrada YD, Singer G, Krueger JG, Guttman-Yassky E. Large-Scale Blood Proteomic Analysis Across Different Inflammatory Skin Conditions Reveals Extensive Immune Dysregulation With Distinct Biomarker Profiles. Allergy. 2025 Nov 17. doi: 10.1111\/all.70157. Epub ahead of print. PMID: 41246813.<\/p>\n","protected":false},"excerpt":{"rendered":"

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