{"id":1959,"date":"2026-05-28T05:40:58","date_gmt":"2026-05-28T05:40:58","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/?p=1959"},"modified":"2026-05-28T05:41:00","modified_gmt":"2026-05-28T05:41:00","slug":"olink-ftld","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/accelerating-science-in-china\/olink-ftld\/","title":{"rendered":"\u9057\u4f20\u6027\u989d\u989e\u53f6\u75f4\u5446\u8bca\u65ad\u7a81\u7834\uff0c\u5927\u89c4\u6a21\u8111\u810a\u6db2\u86cb\u767d\u8c31\u63ed\u79d8\u6838\u5fc3\u673a\u5236"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/www.thermofisher.cn\/cn\/zh\/home\/communities-social\/socialhub\/blog-subscribe.html?icid=cn-blog-subscribe\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"176\" src=\"http:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-1024x176.jpg\" alt=\"\" class=\"wp-image-2271\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-1024x176.jpg 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-300x52.jpg 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-768x132.jpg 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-1536x264.jpg 1536w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/05\/779-\u00d7-134-3-2048x352.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u9057\u4f20\u6027\u989d\u989e\u53f6\u53d8\u6027\u8bca\u65ad\u56f0\u5883\"><strong>\u9057\u4f20\u6027\u989d\u989e\u53f6\u53d8\u6027\u8bca\u65ad\u56f0\u5883<\/strong><\/h2>\n\n\n\n<p><strong>\u9057\u4f20\u6027\u989d\u989e\u53f6\u53d8\u6027<\/strong><strong>\uff08<\/strong><strong>FTLD<\/strong><strong>\uff09<\/strong>\u662f\u4ec5\u6b21\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u5e38\u89c1\u65e9\u53d1\u6027\u75f4\u5446\u7c7b\u578b\uff0c\u5177\u6709<strong>\u9ad8\u5ea6\u9057\u4f20\u5f02\u8d28\u6027\u548c\u75c5\u7406\u590d\u6742\u6027<\/strong>\u3002\u76ee\u524dFTLD\u7684\u4e34\u5e8a\u8bca\u65ad\u9762\u4e34\u4e24\u5927\u74f6\u9888\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7f3a\u4e4f\u7279\u5f02\u6027\u4f53\u6db2\u6807\u5fd7\u7269\uff1a<\/strong>\u73b0\u6709\u6307\u6807\u5982\u795e\u7ecf\u4e1d\u8f7b\u94fe\uff08NEFL\uff09\u867d\u80fd\u53cd\u6620\u795e\u7ecf\u9000\u884c\u6027\u635f\u4f24\uff0c\u4f46\u65e0\u6cd5\u533a\u5206FTLD\u7684\u4e0d\u540c\u75c5\u7406\u4e9a\u578b\u3002<\/li>\n\n\n\n<li><strong>\u786e\u8bca\u4f9d\u8d56\u6b7b\u540e\u75c5\u7406\uff1a<\/strong>\u6d3b\u4f53\u9636\u6bb5\u96be\u4ee5\u7cbe\u51c6\u9884\u5224\u6f5c\u5728\u75c5\u7406\u673a\u5236\uff0c\u533a\u5206\u8fd9\u4e9b\u4e9a\u578b\u9700\u4f9d\u9760\u57fa\u56e0\u68c0\u6d4b\u6216\u5c38\u68c0\uff0c\u9650\u5236\u4e86\u65e9\u671f\u5e72\u9884\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5f00\u53d1\u9ad8\u7279\u5f02\u6027\u3001\u9ad8\u7075\u654f\u5ea6\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ca\u8bca\u65ad\u5de5\u5177\uff0c\u5bf9\u4e8eFTLD\u7684\u65e9\u671f\u8bca\u65ad\u3001\u75c5\u7406\u5206\u578b\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u90fd\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"436\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724790-1024x436.png\" alt=\"\" class=\"wp-image-1967\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724790-1024x436.png 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724790-300x128.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724790-768x327.png 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724790.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u8377\u5170\u795e\u7ecf\u5185\u79d1\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u4e2d\u5fc3<\/strong>\u8054\u5408\u591a\u56fd\u56e2\u961f\u5728\u795e\u7ecf\u79d1\u5b66\u9876\u520a<em>\u300aBrain\u300b<\/em>\u4e0a\u53d1\u8868\u4e86\u4e00\u9879\u5f00\u521b\u6027\u7814\u7a76\uff0c\u901a\u8fc7<strong>\u5927\u89c4\u6a21\u8111\u810a\u6db2\uff08CSF\uff09\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790<\/strong>\uff0c\u9996\u6b21\u7cfb\u7edf\u63ed\u793a\u4e86FTLD\u4e0d\u540c\u9057\u4f20\u4e9a\u578b\u7684\u7279\u5f02\u6027\u5206\u5b50\u7279\u5f81\uff0c\u5e76\u5f00\u53d1\u51fa\u8bca\u65ad\u51c6\u786e\u7387\u9ad8\u8fbe96%\u7684\u86cb\u767d\u7ec4\u5408\u5de5\u5177\u3002\u8fd9\u4e00\u6210\u679c\u4e0d\u4ec5\u4e3a\u4e34\u5e8a\u8bca\u65ad\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\uff0c\u66f4\u6df1\u5165\u89e3\u6790\u4e86\u75be\u75c5\u80cc\u540e\u7684\u75c5\u7406\u673a\u5236\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u961f\u5217\u8bbe\u8ba1\"><strong>\u961f\u5217\u8bbe\u8ba1<\/strong><\/h2>\n\n\n\n<p>\u7814\u7a76\u91c7\u7528<strong>\u201c\u591a\u4e2d\u5fc3\u961f\u5217+Olink\u9ad8\u901a\u91cf\u86cb\u767d\u7ec4\u5b66\u6280\u672f\u201d<\/strong>\u7ecf\u5178\u8bbe\u8ba1\uff0c\u9488\u5bf9\u6765\u81ea\u56fd\u9645\u591a\u4e2d\u5fc3\u961f\u5217\u7684\u8111\u810a\u6db2\u6837\u672c\uff0c\u91c7\u7528Olink Explore\u5e73\u53f0\u68c0\u6d4b\u4e862,900\u591a\u79cd\u86cb\u767d\u8d28\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u53d1\u73b0\u961f\u5217\uff08n=228\uff09\uff1a\u6765\u81ea<strong>\u56fd\u9645\u9057\u4f20\u989d\u989e\u53f6\u75f4\u5446\u5021\u8bae\uff08GENFI\uff09\u961f\u5217<\/strong>\u768413\u4e2a\u7814\u7a76\u4e2d\u5fc3\uff0c\u5305\u62ec\u75c7\u72b6\u524d\u643a\u5e26\u8005\u3001\u75c7\u72b6\u6027\u643a\u5e26\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u3002<\/li>\n\n\n\n<li>\u9a8c\u8bc1\u961f\u5217\uff08n=164\uff09\uff1a\u6574\u5408<strong>\u4f0a\u62c9\u65af\u8c1f\u533b\u5b66\u4e2d\u5fc3\u548c\u963f\u59c6\u65af\u7279\u4e39\u75f4\u5446\u961f\u5217<\/strong>\uff0c\u8986\u76d6\u6563\u53d1\u6027FTLD\u60a3\u8005\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u6838\u5fc3\u7ed3\u679c\"><strong>\u6838\u5fc3\u7ed3\u679c<\/strong><\/h2>\n\n\n\n<p id=\"h-\"><strong>\u4e0d\u540c\u9057\u4f20\u4e9a\u578b\u7684\u86cb\u767d\u7ec4\u7279\u5f81<\/strong><\/p>\n\n\n\n<p>\u8be5\u7814\u7a76<strong>\u9996\u6b21\u63ed\u793a\u4e86FTLD\u4e09\u5927\u9057\u4f20\u4e9a\u578b\uff08C9orf72\u3001GRN\u3001MAPT\uff09\u7684\u7279\u5f02\u6027\u8111\u810a\u6db2\u86cb\u767d\u8c31<\/strong>\uff0c\u5e76\u53d1\u73b0\u4e86\u8de8\u4e9a\u578b\u7684\u5171\u6027\u6807\u5fd7\u7269\uff1a<\/p>\n\n\n\n<p><strong>1. \u5171\u6027\u5dee\u5f02\u86cb\u767d\uff1aNEFL\u4e0eTPM3<\/strong><\/p>\n\n\n\n<p id=\"h-\"><strong>\u4e0d\u540c\u9057\u4f20\u4e9a\u578b\u7684\u86cb\u767d\u7ec4\u7279\u5f81<\/strong><\/p>\n\n\n\n<p>\u8be5\u7814\u7a76<strong>\u9996\u6b21\u63ed\u793a\u4e86FTLD\u4e09\u5927\u9057\u4f20\u4e9a\u578b\uff08C9orf72\u3001GRN\u3001MAPT\uff09\u7684\u7279\u5f02\u6027\u8111\u810a\u6db2\u86cb\u767d\u8c31<\/strong>\uff0c\u5e76\u53d1\u73b0\u4e86\u8de8\u4e9a\u578b\u7684\u5171\u6027\u6807\u5fd7\u7269\uff1a<\/p>\n\n\n\n<p><strong>1. \u5171\u6027\u5dee\u5f02\u86cb\u767d\uff1aNEFL\u4e0eTPM3<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NEFL\uff08\u795e\u7ecf\u4e1d\u8f7b\u94fe\uff09\uff1a\u5df2\u77e5\u7684\u795e\u7ecf\u9000\u884c\u6807\u5fd7\u7269\uff0c\u5728\u5168\u90e8\u75c7\u72b6\u6027\u643a\u5e26\u8005\u4e2d\u4e0a\u8c03\uff0c\u9a8c\u8bc1\u4e86\u5176\u4f5c\u4e3a\u6838\u5fc3\u635f\u4f24\u6307\u6807\u7684\u4ef7\u503c\u3002<\/li>\n\n\n\n<li>TPM3\uff08\u539f\u808c\u7403\u86cb\u767d3\uff09\uff1a\u65b0\u578b\u6f5c\u529b\u6807\u5fd7\u7269\uff0c\u4e0eNEFL\u7c7b\u4f3c\uff0c\u5728\u6240\u6709\u4e9a\u578b\u4e2d\u663e\u8457\u4e0a\u8c03\uff0c\u53ef\u80fd\u53cd\u6620\u8f74\u7a81\u635f\u4f24\u673a\u5236\u3002TPM3\u4f5c\u4e3a\u808c\u52a8\u86cb\u767d\u7ed3\u5408\u86cb\u767d\uff0c\u5728\u7a81\u89e6\u7ec6\u80de\u9aa8\u67b6\u4e2d\u8d77\u8c03\u63a7\u4f5c\u7528\uff0c\u5176\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u89d2\u8272\u503c\u5f97\u6df1\u5165\u63a2\u7d22\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"716\" height=\"948\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724791.png\" alt=\"\" class=\"wp-image-1968\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724791.png 716w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724791-227x300.png 227w\" sizes=\"auto, (max-width: 716px) 100vw, 716px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u53d1\u73b0\u961f\u5217\u5dee\u5f02\u86cb\u767d\u706b\u5c71\u56fe<\/p>\n\n\n\n<p><strong>2. \u4e9a\u578b\u7279\u5f02\u6027\u7279\u5f81\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MAPT\u7a81\u53d8\u643a\u5e26\u8005\uff1a<\/strong>63\u79cd\u86cb\u767d\u4e0a\u8c03\uff0c\u5bcc\u96c6\u4e8e\u5148\u5929\u514d\u75ab\u5e94\u7b54\u548c\u7ec6\u80de\u6d3b\u5316\u901a\u8def\u3002\u5176\u4e2dMMP10\u4e0a\u8c03\u5e45\u5ea6\u6700\u5927\uff0c\u63d0\u793a\u795e\u7ecf\u708e\u75c7\u5728tau\u75c5\u7406\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002<\/li>\n\n\n\n<li><strong>C9orf72\u7a81\u53d8\u643a\u5e26\u8005\uff1a<\/strong>4\u79cd\u86cb\u767d\u4e0a\u8c03\uff08NEFL\u3001TPM3\u3001RBFOX3\u3001ELAVL4\uff09\uff0c\u5747\u4e0e\u80fd\u91cf\u4ee3\u8c22\u76f8\u5173\u3002ELAVL4\u4f5c\u4e3aRNA\u7ed3\u5408\u86cb\u767d\uff0c\u6b64\u524d\u5728\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u4e2d\u6709\u7814\u7a76\uff0c\u672c\u6b21\u7814\u7a76\u63d0\u793a\u4e86\u5176\u4e0eC9orf72\u75be\u75c5\u7684\u5173\u8054\u3002<\/li>\n\n\n\n<li><strong>GRN\u7a81\u53d8\u643a\u5e26\u8005\uff1a<\/strong>6\u79cd\u86cb\u767d\u5931\u8c03\uff083\u4e0a\u8c03\u30013\u4e0b\u8c03\uff09\uff0c\u5bcc\u96c6\u4e8e\u795e\u7ecf\u5143\u53d1\u80b2\u548c\u7a81\u89e6\u6295\u5c04\u901a\u8def\u3002\u521b\u65b0\u6027\u53d1\u73b0\u662f<strong>SEMA3G\u7684\u4e0b\u8c03<\/strong>\uff0c\u8be5\u86cb\u767d\u4f5c\u4e3a\u8840\u7ba1\u6e90\u6027\u7a81\u89e6\u7ec4\u7ec7\u8005\uff0c\u53ef\u80fd\u94fe\u63a5GRN\u5355\u500d\u4f53\u4e0d\u8db3\u4e0e\u795e\u7ecf\u8840\u7ba1\u5355\u5143\u529f\u80fd\u969c\u788d\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"759\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724792-1024x759.png\" alt=\"\" class=\"wp-image-1969\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724792-1024x759.png 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724792-300x222.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724792-768x569.png 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724792.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center\">\u53d1\u73b0\u961f\u5217\u4e2d\u4e0d\u540c\u4e9a\u7ec4\u7684\u86cb\u767d\u53d8\u5316<\/p>\n\n\n\n<p><strong>3. \u8de8\u75be\u75c5\u86cb\u767d\u7279\u5f81\u5bf9\u6bd4\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09<\/strong>\uff1a\u90e8\u5206\u86cb\u767d\u5b58\u5728\u91cd\u53e0\uff08\u5982 ITGB2\u3001MAP2K1 \u7b49\uff09\uff0c\u4f46 MAPT \u7a81\u53d8\u643a\u5e26\u8005\u6709 40 \u79cd\u72ec\u7279\u5dee\u5f02\u86cb\u767d\uff08\u4ee5\u708e\u75c7\u6807\u5fd7\u7269\u4e3a\u4e3b\uff09\uff0c\u63d0\u793a\u867d\u540c\u4e3a tau\u75c5\uff0cFTLD-tau \u4e0e AD \u7684\u75c5\u7406\u673a\u5236\u5b58\u5728\u5dee\u5f02\uff1b&nbsp;<\/li>\n\n\n\n<li><strong>\u4e0e\u03b1- \u7a81\u89e6\u6838\u86cb\u767d\u75c5<\/strong>\uff08\u5e15\u91d1\u68ee\u75c5\u3001\u8def\u6613\u4f53\u75f4\u5446\uff09\uff1a\u65e0\u663e\u8457\u91cd\u53e0\u5dee\u5f02\u86cb\u767d\uff0c\u8868\u660eFTLD\u7684\u7279\u5f02\u6027\u86cb\u767d\u8d28\u7ec4\u7279\u5f81\u3002<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"392\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724793-1024x392.png\" alt=\"\" class=\"wp-image-1970\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724793-1024x392.png 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724793-300x115.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724793-768x294.png 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724793.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u8bca\u65ad\u7a81\u7834\uff1a\u8bca\u65adpanel\u8868\u73b0\u4f18\u5f02<\/strong><\/p>\n\n\n\n<p>\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u5e76\u9a8c\u8bc1\u4e86\u4e24\u4e2a\u8bca\u65adPanel\uff0c\u5728\u72ec\u7acb\u961f\u5217\u4e2d\u8868\u73b0\u5353\u8d8a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTLD\u9274\u522bPanel\uff086\u86cb\u767d\uff09<\/strong>\uff1a<\/li>\n<\/ul>\n\n\n\n<p>NEFL+RBFOX3+NPTX1+TFF1+ENTPD5+CNP<\/p>\n\n\n\n<p>\u80fd\u533a\u5206\u6240\u6709FTLD\u60a3\u8005\u4e0e\u5bf9\u7167\uff0c\u9a8c\u8bc1\u961f\u5217AUC=0.94\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TDP\u75c5\u7406Panel\uff087\u86cb\u767d\uff09<\/strong>\uff1a<\/li>\n<\/ul>\n\n\n\n<p>NEFL+RBFOX3+CBLN4+ENTPD5+CCL25+CNP+MMP1<\/p>\n\n\n\n<p>\u80fd\u533a\u5206FTLD-TDP\u60a3\u8005\u4e0e\u5bf9\u7167\uff0c\u9a8c\u8bc1\u961f\u5217AUC=0.96\u3002<\/p>\n\n\n\n<p>\u5173\u952e\u9a8c\u8bc1\uff1a<strong>\u5373\u4f7f\u6392\u9664NEFL\uff0c\u66ff\u4ee3Panel\u4ecd\u4fdd\u6301\u9ad8\u51c6\u786e\u5ea6<\/strong>\uff08AUC 0.91-0.90\uff09\uff0c\u8bf4\u660e\u65b0\u86cb\u767d\u7ec4\u5408\u7684\u72ec\u7acb\u8bca\u65ad\u4ef7\u503c\u3002Panel\u6027\u80fd\u663e\u8457\u4f18\u4e8e\u5355\u7528NEFL\uff08AUC 0.89\u548c0.85\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"403\" src=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724794-1024x403.png\" alt=\"\" class=\"wp-image-1971\" srcset=\"https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724794-1024x403.png 1024w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724794-300x118.png 300w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724794-768x302.png 768w, https:\/\/admin.acceleratingscience.com\/accelerating-science-in-china\/wp-content\/uploads\/sites\/28\/2026\/04\/\u56fe\u724794.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u5199\u5728\u6700\u540e\"><strong>\u5199\u5728\u6700\u540e<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u4e0d\u4ec5\u4e3aFTLD\u75c5\u7406\u673a\u5236\u7684\u7406\u89e3\u63d0\u4f9b\u4e86\u6df1\u5165\u89c1\u89e3\uff0c\u66f4\u63d0\u4f9b\u4e86\u91cc\u7a0b\u7891\u5f0f\u7a81\u7834\u7684\u8bca\u65ad\u5de5\u5177\u3002\u6838\u5fc3\u4ef7\u503c\u4e0d\u4ec5\u5728\u4e8e\u53d1\u73b0\u4e86\u4e9a\u578b\u7279\u5f02\u6027\u86cb\u767d\u7279\u5f81\u548c\u9ad8\u51c6\u786e\u6027\u8bca\u65adpanel\uff0c\u4e5f\u9a8c\u8bc1\u4e86Olink PEA\u6280\u672f\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4f53\u6db2\u6807\u5fd7\u7269\u7814\u7a76\u4e2d\u7684\u4f18\u52bf\uff0c\u4e3a\u540e\u7eed\u76f8\u5173\u7814\u7a76\u63d0\u4f9b\u4e86\u53ef\u501f\u9274\u7684\u6280\u672f\u65b9\u6848\u548c\u7814\u7a76\u6846\u67b6\u3002\u5f00\u53d1\u7684\u4e24\u4e2a\u8bca\u65adPanel\u5728\u72ec\u7acb\u961f\u5217\u4e2d\u8868\u73b0\u51fa\u8272\uff0c\u6709\u671b\u5e94\u7528\u4e8eFTLD\u7684\u4e34\u5e8a\u8bca\u65ad\u3001\u9274\u522b\u8bca\u65ad\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\uff0c\u6700\u7ec8\u6539\u5584\u60a3\u8005\u7684\u8bca\u7597\u7ed3\u5c40\u3002<\/p>\n\n\n\n<p><em>\u201cIn contrast, our use of the Olink\u00ae platform provided broader coverage of immune-related proteins. This allowed us to uncover a strong connection between immune pathways and MAPT, adding an important dimension to the current proteomic landscape in FTLD.\u201d &nbsp; &#8211; \u539f\u6587\u6458\u5f55<\/em><\/p>\n\n\n\n<p><strong>\u63a8\u8350\u9605\u8bfb\uff1a<\/strong><\/p>\n\n\n\n<p>Olink<a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg4ODU0NTQ5Nw==&amp;action=getalbum&amp;album_id=1893093062315163655#wechat_redirect\" target=\"_blank\" rel=\"noreferrer noopener\">\u795e\u7ecf\u4e13\u9898<\/a><\/p>\n\n\n\n<p><strong>\u53c2\u8003\u8d44\u6599\uff1a<\/strong><\/p>\n\n\n\n<p>1.&nbsp;De Houwer JFH, Dopper EG, van Buuren R,&nbsp;<em>et.al<\/em>. Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration. Brain. 2025 Dec 4:awaf457. doi: 10.1093\/brain\/awaf457. Epub ahead of print. 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