The Orbitrap Astral Mass Spectrometer and host cell proteins
Recombinant biotherapeutics have transformed medicine, but the presence of host cell proteins (HCPs) poses a risk to their safety and efficacy. Purification methods struggle to effectively remove residual HCPs, which can compromise the integrity of these vital drugs. However, the Thermo Scientific Orbitrap Astral Mass Spectrometer offers a solution, revolutionizing HCP detection and monoclonal antibody (mAb) analysis. Want to see how this achieved? Download our conference posters here.

Traditionally, assessing the impact of individual HCPs on immunogenic relevance and product stability has been challenging. Liquid chromatography-mass spectrometry (LC-MS) emerged as a valuable tool, providing a broader view than ELISA. However, the dynamic range between HCPs and the drug product made detecting low concentrations difficult.
The Orbitrap Astral Mass Spectrometer takes HCP detection to a new level. With unparalleled sensitivity, it identifies HCPs at sub-ppm levels, ensuring the utmost safety and efficacy of biotherapeutic drugs. Check out our poster in which we demonstrate how you can achieve clear identification of HCPs at sub-ppm level with increased throughput.
The Orbitrap Astral Mass Spectrometer and monoclonal antibodies
This ground-breaking instrument enables scientists to achieve comprehensive mAb analysis across diverse modalities on a single platform with exceptional throughput.
The Orbitrap Astral Mass Spectrometer’s high-resolution accurate-mass analyzer sets it apart. Its unique workflow captures ions during the initial MS1 Orbitrap analysis, trapping and fragmenting them at remarkable speeds. This high-throughput analysis maintains precision.
Harnessing the power of asymmetric ion mirrors and ion foil, the Orbitrap Astral Mass Spectrometer achieves up to 80,000 resolution. This exceptional clarity enables scientists to analyze complex mAb samples and detect even subtle molecular variations. The ion foil shapes and focuses ions, enhancing resolution and sensitivity, crucial for most in-depth and accurate understanding of mAb composition.
The Orbitrap Astral Mass Spectrometer consolidates various analytical techniques into a single platform, streamlining workflows and expediting mAb characterization. From peptide mapping to native intact mass analysis, researchers can efficiently analyze a large number of samples, facilitating faster research and development in the biopharmaceutical industry.
Ready to unlock the potential of the Orbitrap Astral Mass Spectrometer?
Download our posters now to explore the possibilities and discover how this ground-breaking instrument can transform HCP detection and mAb analysis. Click here to access the posters and revolutionize your research.
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