In today’s world of scientific research, advancements in technology and methodologies play a pivotal role in unravelling new insights and pushing the boundaries of knowledge. In this blog, we are excited to present three conference research posters that illustrate the latest developments in mass spectrometry. These posters focus on topics such as drug-payload localization, adeno-associated virus characterization, and PROTAC drug metabolite localization.
Enhancing Drug-Payload Localization in Antibody-Drug Conjugates with a Middle-Down Approach Utilizing Proton Transfer Charge Reduction on a Modified Orbitrap Ascend: This poster explores a new approach to improve the localization of drug-payloads in antibody-drug conjugates (ADCs). By utilizing a middle-down approach that incorporates proton transfer charge reduction on a modified Orbitrap Ascend mass spectrometer, researchers have achieved enhanced accuracy in identifying and localizing drug-payloads within ADCs.
Characterization of Adeno-Associated Virus (AAV2) Capsid Proteoforms Using Multiple Ion Activations on an Orbitrap Tribrid Instrument: The second poster focuses on the characterization of adeno-associated virus (AAV2) capsid proteoforms using multiple ion activations on the Orbitrap Ascend MS. By employing this advanced mass spectrometry technique, researchers have gained valuable results into the structural heterogeneity of AAV9 capsids.
Confident Transformation Site Localization of PROTAC Drug Metabolites Facilitated by Multi-Stage Fragmentation LC-HRAM-MS: Finally, the third poster highlights the transformation site localization of PROTAC drug metabolites using multi-stage fragmentation LC-HRAM-MS. This technique allows researchers to precisely determine the site of transformation for PROTAC drug metabolites, providing vital information for drug development and optimization. The poster showcases the power of mass spectrometry in understanding the complex metabolic pathways of drugs.
To gain full access to these exclusive posters, please download them here.
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