{"id":17360,"date":"2024-03-26T14:48:28","date_gmt":"2024-03-26T14:48:28","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/?p=17360"},"modified":"2026-09-18T22:35:27","modified_gmt":"2026-09-18T22:35:27","slug":"unveiling-hidden-impurities-lc-hrms-for-biopharmaceutical-analysis","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/unveiling-hidden-impurities-lc-hrms-for-biopharmaceutical-analysis\/","title":{"rendered":"Unveiling Hidden Impurities: LC-HRMS for Biopharmaceutical Analysis"},"content":{"rendered":"\n<p><a href=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-admin\/edit.php?post_type=post\"><\/a><em>This is the fifth in a five-part BioPharma Blog Series.<\/em> <\/p>\n\n\n\n<p>Have you ever wondered how advanced scientific techniques can unveil hidden impurities in the biopharmaceutical world?<\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2-1024x576.jpg\" alt=\"\" class=\"wp-image-17369\" style=\"width:546px;height:auto\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2-1024x576.jpg 1024w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2-300x169.jpg 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2-768x432.jpg 768w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2-1536x864.jpg 1536w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/03\/Blog-2048x1152-2.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Liquid chromatography high-resolution mass spectrometry (LC-HRMS) is one such cutting-edge method gaining traction in untargeted screening and identification of small-molecule impurities, particularly leachables from container closure systems.<\/p>\n\n\n\n<p>In contrast to controlled extractables studies, leachables studies are carried out on the final drug formulation, where the presence of the protein drug matrix, containing relatively high levels of the active protein(s) and excipients, presents an analytical challenge for LC-HRMS analysis. Due to this complexity, confident proposal of unknown compound structures typically requires high-resolution mass spectra with MS2 and MSn fragmentation.<\/p>\n\n\n\n<p>At a recent USA based conference, a poster was presented that detailed how the Thermo Scientific Vanquish Horizon UHPLC system coupled to a Thermo Scientific Orbitrap Exploris 240 MS compared to a typical LC-QTOF screening method, and the results are available for you to view.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/global\/forms\/industrial\/identification-unknown-compounds-observed-leachables-study.html?cid=E.23CMD.PB103.17954.01\" target=\"_blank\" rel=\"noreferrer noopener\">Download our free impurities poster now.<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-related-information\"><strong>Related information<\/strong><\/h3>\n\n\n\n<p>Blog 1: <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/revolutionizing-host-cell-protein-detection-in-biopharma\/\" target=\"_blank\" rel=\"noreferrer noopener\">Revolutionizing Host Cell Protein Detection and mAb Analysis in Biopharmaceuticals<\/a><br>Blog 2: <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/poster-series-on-biopharma-column-chemistry\/\" target=\"_blank\" rel=\"noreferrer noopener\">Poster Series: A Journey into the World of Biopharma Column Chemistry<\/a><br>Blog 3: <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/take-a-step-closer-to-unlocking-full-potential-of-aav-gene-therapy-download-the-poster\/\" target=\"_blank\" rel=\"noreferrer noopener\">Take a Step Closer to Unlocking Full Potential of AAV Gene Therapy \u2013 Download the Poster<\/a><br>Blog 4: <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/unlocking-the-future-of-medicine-exploring-therapeutic-oligonucleotides\/\" target=\"_blank\" rel=\"noreferrer noopener\">Unlocking the Future of Medicine: Exploring Therapeutic Oligonucleotides<\/a><br>Download our <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/global\/forms\/industrial\/unlocking-future-medicine.html?cid=E.23CMD.PB103.17953.01\" target=\"_blank\" rel=\"noreferrer noopener\">conference posters<\/a> to see how we applied advanced analytical technology to achieve the best results for oligonucleotide analysis<\/p>\n\n\n\n<p>On LinkedIn? Visit our&nbsp;<a href=\"https:\/\/www.linkedin.com\/showcase\/chromatography-&amp;-mass-spectrometry\/posts\/?feedView=all\" target=\"_blank\" rel=\"noreferrer noopener\">LinkedIn page<\/a> #biopharmaceutical #UHPLC<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This is the fifth in a five-part BioPharma Blog Series. Have you ever wondered how advanced scientific techniques can unveil hidden impurities in the biopharmaceutical world? Liquid chromatography high-resolution mass spectrometry (LC-HRMS) is one such cutting-edge method gaining traction in untargeted screening and identification of small-molecule impurities, particularly leachables from container closure systems. In contrast<\/p>\n","protected":false},"author":1327,"featured_media":17369,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[38,1803],"tags":[41,1802,1801,15],"division":[],"class_list":{"0":"post-17360","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-biopharmaceutical","8":"category-uhplc","9":"tag-biopharmaceutical","10":"tag-impurity-analysis","11":"tag-lc-hrms","12":"tag-uhplc","13":"entry"},"_selected_authors":[1996],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- 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