{"id":18164,"date":"2024-12-17T22:23:47","date_gmt":"2024-12-17T22:23:47","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/?p=18164"},"modified":"2026-09-11T22:16:36","modified_gmt":"2026-09-11T22:16:36","slug":"advancing-pfas-detection-in-pharmaceutical-manufacturing-with-lc-hram-ms","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/advancing-pfas-detection-in-pharmaceutical-manufacturing-with-lc-hram-ms\/","title":{"rendered":"Advancing PFAS Detection in Pharmaceutical Manufacturing with LC-HRAM-MS"},"content":{"rendered":"\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2-1024x683.jpg\" alt=\"\" class=\"wp-image-18171\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2-1024x683.jpg 1024w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2-300x200.jpg 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2-768x512.jpg 768w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2-96x65.jpg 96w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/shutterstock_2238988589-1200x800-2.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>In the realm of pharmaceutical manufacturing, the detection and analysis of perfluoroalkyl substances (PFAS) have become a growing source of concern due to their persistence and potential health risks. The latest application note from SGS presents a groundbreaking approach to PFAS screening and quantification, leveraging the capabilities of the Thermo Scientific Vanquish UHPLC and Orbitrap Exploris 120 high-resolution mass spectrometer (HRAM-MS).<\/p>\n\n\n\n<p>This application note demonstrates the sensitive detection and identification of both known and unknown PFAS compounds in extracts from common pharmaceutical manufacturing and packaging materials. By employing a combined targeted and non-targeted approach, the study highlights how the integration of the Vanquish UHPLC and Orbitrap Exploris 120 HRAM-MS can revolutionize PFAS analysis.<\/p>\n\n\n\n<p>The key benefits of this method include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Combined Targeted and Non-Targeted Screening: One injection allows for both the quantitation of specific PFAS compounds and the screening for additional, previously unidentified PFAS contaminants.<\/li>\n\n\n\n<li>Enhanced Analytical Confidence: The use of a PFAS analysis kit and delay column minimizes background PFAS interference, thereby increasing the reliability of the results.<\/li>\n\n\n\n<li>Regulatory Compliance: Utilizing Chromeleon CDS ensures that the data acquisition and quantitative analysis comply with 21 CFR Part 11, a crucial requirement for pharmaceutical applications.<\/li>\n\n\n\n<li>High Sensitivity and Specificity: The method provides unequivocal identification and quantification of PFAS compounds down to sub-ppb levels.<\/li>\n<\/ul>\n\n\n\n<p>The study underscores the efficacy of the Orbitrap Exploris 120 HRAM-MS in providing a comprehensive solution for PFAS analysis. By integrating both targeted and non-targeted approaches, this method not only enhances the detection sensitivity and specificity but also expands the scope of detectable PFAS contaminants. This dual approach is a significant advancement in extractables screening, offering pharmaceutical manufacturers a robust tool for ensuring the safety and compliance of their products.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/CMD\/Application-Notes\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"782\" height=\"1024\" src=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en-800x1048px-782x1024.jpg\" alt=\"Download our joint application note\" class=\"wp-image-18170\" style=\"width:147px;height:auto\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en-800x1048px-782x1024.jpg 782w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en-800x1048px-229x300.jpg 229w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en-800x1048px-768x1006.jpg 768w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2024\/12\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en-800x1048px.jpg 800w\" sizes=\"auto, (max-width: 782px) 100vw, 782px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:88%\">\n<p><a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/CMD\/Application-Notes\/an-003388-pb-pfas-orbitrap-exploris-120-extractables-an003388-na-en.pdf\" target=\"_blank\" rel=\"noopener\">Download our joint application note<\/a> to learn about Comprehensive PFAS screening in pharmaceutical packaging and medical devices by LC-HRAM-MS<\/p>\n<\/div>\n<\/div>\n\n\n\n<p>This collaboration between SGS and Thermo Fisher Scientific illustrates a leap forward in PFAS screening technology, promising higher quality results, increased confidence, and regulatory compliance in the pharmaceutical manufacturing process.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the realm of pharmaceutical manufacturing, the detection and analysis of perfluoroalkyl substances (PFAS) have become a growing source of concern due to their persistence and potential health risks. The latest application note from SGS presents a groundbreaking approach to PFAS screening and quantification, leveraging the capabilities of the Thermo Scientific Vanquish UHPLC and Orbitrap<\/p>\n","protected":false},"author":1761,"featured_media":18171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[100,28],"tags":[136,85,104,31],"division":[],"class_list":{"0":"post-18164","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-pfas","8":"category-pharmaceutical","9":"tag-hram","10":"tag-lc-ms","11":"tag-pfas","12":"tag-pharmaceutical","13":"entry"},"_selected_authors":[1971],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- 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