{"id":19240,"date":"2025-10-24T07:48:16","date_gmt":"2025-10-24T07:48:16","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/?p=19240"},"modified":"2025-10-29T07:47:56","modified_gmt":"2025-10-29T07:47:56","slug":"advancing-drug-analysis-with-verispray-paperspray-mass-spectrometry","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/advancing-drug-analysis-with-verispray-paperspray-mass-spectrometry\/","title":{"rendered":"Advancing Drug Analysis with VeriSpray PaperSpray Mass Spectrometry"},"content":{"rendered":"\n<p>At the January 2025 CFSRE Seized Drugs Symposium, a Thermo Fisher Scientific\u2013sponsored workshop showcased the potential of Thermo Scientific <strong>VeriSpray PaperSpray mass spectrometry (PS-MS)<\/strong> to transform drug analysis workflows in both forensic and clinical toxicology. Three researchers from King\u2019s College London (KCL)\u2014<strong>PhD candidate Stefania Boccuzzi<\/strong> and <strong>MSc graduates Marwa AlJanahi and Saeed Almheiri<\/strong>\u2014presented their findings on how to optimise this cutting-edge technique for faster, more sensitive, and more cost-effective detection of drugs of abuse.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Advancing-Drug-Analysis-with-VeriSpray-PaperSpray-Mass-Spectrometry-blog-1024x512.png\" alt=\"Thermo Fisher Scientific's Edward Goucher and Alexandra Graham pictured beside KCL's Stefania Boccuzzi and Vincenzo Abbate\" class=\"wp-image-19248\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Advancing-Drug-Analysis-with-VeriSpray-PaperSpray-Mass-Spectrometry-blog-1024x512.png 1024w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Advancing-Drug-Analysis-with-VeriSpray-PaperSpray-Mass-Spectrometry-blog-300x150.png 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Advancing-Drug-Analysis-with-VeriSpray-PaperSpray-Mass-Spectrometry-blog-768x384.png 768w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Advancing-Drug-Analysis-with-VeriSpray-PaperSpray-Mass-Spectrometry-blog.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center has-small-font-size\">Thermo Fisher Scientific&#8217;s Edward Goucher and Alexandra Graham pictured beside KCL&#8217;s Stefania Boccuzzi and Vincenzo Abbate<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-verispray-a-simpler-faster-path-to-results\"><strong>Why VeriSpray? A simpler, faster path to results<\/strong><\/h3>\n\n\n\n<p>Traditional LC-MS workflows can be powerful, but when labs are overwhelmed by backlogs, the time and complexity of sample preparation and chromatography can be limiting. <strong>VeriSpray offers a remarkably simplified path to MS analysis<\/strong>, directly ionizing complex matrices using a paper substrate\u2014no LC step required.<\/p>\n\n\n\n<p>Key benefits include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>&lt;2-minute results<\/strong> thanks to minimal sample prep and elimination of LC<\/li>\n\n\n\n<li><strong>Reduced cost per test<\/strong> by cutting solvent use and simplifying training requirements<\/li>\n\n\n\n<li><strong>Automation-ready<\/strong> with support for unattended operation of up to 240 samples<\/li>\n\n\n\n<li><strong>Seamless integration<\/strong> with Thermo Scientific triple quadrupole systems<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"410\" src=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Why-VeriSpray.png\" alt=\"VeriSpray working demo\" class=\"wp-image-19345\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Why-VeriSpray.png 700w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2025\/10\/Why-VeriSpray-300x176.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-enhancing-emergency-toxicology-with-direct-ms-analysis\"><strong>Enhancing emergency toxicology with direct MS analysis<\/strong><\/h3>\n\n\n\n<p>In the emergency room, timely drug identification is critical, but clinicians often rely on patient self-report or symptom-based assessments. Stefania\u2019s PhD research seeks to change that. Her team is developing <strong>a rapid, extraction-free method<\/strong> using VeriSpray PS-MS for the <strong>targeted analysis of plasma samples<\/strong> from patients presenting with acute drug toxicity.<\/p>\n\n\n\n<p>By using <strong>dried matrix spots <\/strong>on a paper substrate and coupling this with a Thermo Scientific <strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer<\/strong>, Stefania\u2019s work provides an alternative screening technique to chromatography, <strong>delivering faster, actionable results to guide early clinical decision-making<\/strong>.<\/p>\n\n\n\n<p><strong>Key takeaways:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Paper spray MS is an ambient ionization technique suitable for emergency toxicology due to its rapid results and minimal sample prep.<\/li>\n\n\n\n<li>Enhancing the paper substrate and adding microextraction steps can <strong>boost sensitivity without sacrificing speed.<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-substrate-matters-boosting-detection-with-paper-treatment\"><strong>Substrate matters: boosting detection with paper treatment<\/strong><\/h3>\n\n\n\n<p>One key limitation of PS-MS is the <strong>interference that can arise from the paper substrate itself<\/strong>. Marwa\u2019s research explored nine different paper treatments, ranging from acids to solvents, to <strong>improve the signal-to-blank (S\/B) ratio<\/strong> when analyzing eight common drugs in whole blood.<\/p>\n\n\n\n<p>The most promising results came from <strong>formic acid <\/strong>and <strong>nitric acid<\/strong> treatments, which significantly enhanced analyte detection. Although these methods are currently time-consuming, Marwa envisions future industrial-scale production of pre-treated cartridges to support <strong>scalable clinical workflows<\/strong>.<\/p>\n\n\n\n<p><strong>Key takeaways:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Substrate optimization can significantly reduce background noise in PS-MS analysis.<\/li>\n\n\n\n<li><strong>Acid-treated paper enhances S\/B ratios<\/strong>, enabling more reliable detection of drugs in blood.<\/li>\n\n\n\n<li>Industrial pre-treatment could make these improvements broadly accessible.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-dllme-meets-paper-spray-improving-sensitivity-in-plasma\"><strong>DLLME meets paper spray: improving sensitivity in plasma<\/strong><\/h3>\n\n\n\n<p>Saeed Almheiri\u2019s presentation focused on dispersive liquid-liquid microextraction (<strong>DLLME) as a sample prep technique<\/strong> to increase sensitivity for PS-MS analysis of drugs in plasma, without adding significant complexity to the workflow.<\/p>\n\n\n\n<p>Using DLLME prior to VeriSpray analysis, Saeed demonstrated <strong>improved detection limits (as low as 0.3 ng\/mL)<\/strong> across a panel of 10 drugs, including buprenorphine, cocaine, and MDMA. Importantly, this method maintained the fast, minimal-prep advantages that make paper spray ionization so appealing.<br><strong>Key takeaways:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>DLLME enhances analyte extraction from plasma, <strong>reducing matrix effects<\/strong> and improving quantitation.<\/li>\n\n\n\n<li>Combining DLLME with VeriSpray maintains a <strong>low-complexity, high-speed workflow.<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-conclusion-a-new-frontier-for-forensic-and-clinical-toxicology\"><strong>Conclusion: a new frontier for forensic and clinical toxicology<\/strong><\/h3>\n\n\n\n<p>The data shared at this workshop underscores the <strong>transformational potential of VeriSpray PaperSpray MS<\/strong>. Whether it&#8217;s detecting drugs in plasma for emergency toxicology, enhancing substrate performance, or integrating clever microextraction steps, researchers at KCL are proving that <strong>simplified workflows can still deliver high sensitivity and accuracy<\/strong>.<br><br>As toxicology labs continue to face growing backlogs and limited resources, adopting a <strong>faster path to MS analysis<\/strong> with VeriSpray could dramatically change how drugs of abuse are detected and quantified, <strong>getting results faster, cutting costs, and ultimately supporting better outcomes<\/strong> in both forensic and clinical environments.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-resources\"><strong>Resources<\/strong>:<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/thermofishermarcom.app.box.com\/s\/gmmhe84v1x9el0fqmh695uszk936iei6\" target=\"_blank\" rel=\"noreferrer noopener\">Watch the full workshop on Box- 2025 Seized Drugs Symposium Workshop and the tag is Toxicology<\/a><\/li>\n\n\n\n<li>Explore the <a href=\"https:\/\/documents.thermofisher.com\/TFS-Assets\/CMD\/brochures\/br-65405-verispray-paperspray-ion-source-br65405-en.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">VeriSpray product brochure<\/a><\/li>\n\n\n\n<li>Case study \u2013 <a href=\"https:\/\/documents.thermofisher.com\/TFS-Assets\/CMD\/Reference-Materials\/cs-002678-lsms-clinical-verispray-toxicology-cs002678-na-en.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening King\u2019s College London aims to investigate its use in emergency department applications<\/a><\/li>\n\n\n\n<li>Case study \u2013 <a href=\"https:\/\/documents.thermofisher.com\/TFS-Assets\/CMD\/Reference-Materials\/cs-000866-ms-verispray-vancouver-island-univ-cs000866-en.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">How paper spray mass spectrometry facilitated harm reduction drug checking<\/a><\/li>\n\n\n\n<li>Past blogs in this toxicology series<ul><li>Sample prep \u2013 <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/sample-prep-strategies-demystified-choosing-the-right-fit-for-your-toxicology-workflow\/\">Sample Preparation Strategies Demystified: Choosing the Right Fit for Your Toxicology Workflow<\/a><\/li><\/ul>\n<ul class=\"wp-block-list\">\n<li>Tox Explorer \u2013 <a href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/beyond-blood-sheffield-teaching-hospitals-nhs-foundation-trust-develops-hram-powered-method-for-post-mortem-toxicology-analysis\/\">Beyond Blood: Sheffield Teaching Hospitals NHS Foundation Trust Develops HRAM-Powered Method for Post-Mortem Toxicology Analysis<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Stay tuned to register for next years symposium at <a href=\"http:\/\/www.forensicsymposium.org\" target=\"_blank\" rel=\"noreferrer noopener\">www.forensicsymposium.org<\/a><\/li>\n\n\n\n<li>Check out our <a href=\"\/content\/lifetech\/global\/en\/home\/industrial\/forensics\/forensic-toxicology\/drug-screening-confirmation.html\">drug screening and confirmation webpage<\/a><\/li>\n<\/ul>\n\n\n\n<p>Visit us on&nbsp;<a href=\"https:\/\/www.linkedin.com\/showcase\/72003132\/admin\/dashboard\/\" target=\"_blank\" rel=\"noreferrer noopener\"><u>LinkedIn:<\/u><\/a>&nbsp;#PSMS #VeriSpray #PaperSprayMS #Toxicology<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the January 2025 CFSRE Seized Drugs Symposium, a Thermo Fisher Scientific\u2013sponsored workshop showcased the potential of Thermo Scientific VeriSpray PaperSpray mass spectrometry (PS-MS) to transform drug analysis workflows in both forensic and clinical toxicology. Three researchers from King\u2019s College London (KCL)\u2014PhD candidate Stefania Boccuzzi and MSc graduates Marwa AlJanahi and Saeed Almheiri\u2014presented their findings<\/p>\n","protected":false},"author":1760,"featured_media":19248,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[111,83,34],"tags":[1748,1788,1828,69],"division":[],"class_list":{"0":"post-19240","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-clinical-research-and-toxicology","8":"category-lc-ms","9":"category-mass-spectrometry","10":"tag-clinical-research-and-toxicology","11":"tag-forensic-toxicology","12":"tag-paperspray-ms","13":"tag-toxicology","14":"entry"},"_selected_authors":[],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- 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