{"id":250,"date":"2019-07-24T14:14:02","date_gmt":"2019-07-24T14:14:02","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/"},"modified":"2026-05-13T00:15:37","modified_gmt":"2026-05-13T00:15:37","slug":"5-quick-tips-to-develop-and-improve-your-ic-method","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/","title":{"rendered":"5 Quick Tips to Develop and Improve Your IC Method"},"content":{"rendered":"<div class=\"lia-message-body-content\">\n<p>Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimise conditions and not sure where to begin? This list is a summary of tips to help you.<\/p>\n<h3 id=\"toc-hId--1902366786\"><em><strong><span class=\"lia-inline-image-display-wrapper lia-image-align-right\" style=\"width: 331px\"><img loading=\"lazy\" decoding=\"async\" class=\"lia-media-image alignright\" title=\"ic-method\" role=\"button\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-0.jpg\" alt=\"ic-method\" width=\"400\" height=\"334\" \/><\/span>The Beginning<\/strong><\/em><\/h3>\n<p><em>Ion Chromatography separations generally follow rules:<\/em><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em><strong>Size <\/strong>&#8211; small ions elute before larger ions.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em><strong>Charge <\/strong>&#8211; single charged ions elute before multiple charged ions.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><em>Column choice is the place to begin. Check out the <a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/CMD\/brochures\/st-70588-ic-column-selection-guide-st70588-en.pdf\" target=\"_blank\" rel=\"nofollow noopener\">column selection guide<\/a> to find out which column suits your application best. There are also other ways in which you can manipulate IC separations. These quick tips will show you how.<\/em><\/p>\n<h3 id=\"toc-hId--1873737635\"><em><strong>1. Eluent strength<\/strong><\/em><\/h3>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Simply changing the strength of your eluent can alter the elution order of some ions.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Change from isocratic 30mM to 48mM Methanesulphonic acid (MSA) and Magnesium will swap places with Potassium (CS16 column).<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>0 mM Carbonate\/1.0mM Bicarbonate will not resolve Chlorate and Phosphate, 6.0mM\/1.0mM will resolve them (AS14 column).<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Look at gradient separations, which sharpen peak shapes and resolution of later eluting peaks, plus improving front end separation.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Add additional steps in your gradient to manipulate particular separations further.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>The column manuals give great examples, find these and related application notes on the respective <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/industrial\/chromatography\/ion-chromatography-ic\/ion-chromatography-columns.html\" target=\"_blank\" rel=\"nofollow noopener\">column webpage<\/a>.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 id=\"toc-hId--1845108484\"><em><strong>2. Temperature<\/strong><\/em><\/h3>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Column temperature is important for run and retention time stability.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Find the temperature range for your column in the manual.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Varying the temperature can change the selectivity of the separation.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Monovalent peaks will tend to elute quicker in comparison with divalent as temperature increases.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>On a CS16 column at 23\u00b0C, magnesium and potassium coelute, separation occurs at 40\u00b0C and even more so at 60\u00b0C.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-264\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-1.jpg\" alt=\"Effect of temperature on IonPac CS16 5mm column, with a 30mm MSA eluent.\" width=\"891\" height=\"549\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-1.jpg 891w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-1-300x185.jpg 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-1-768x473.jpg 768w\" sizes=\"auto, (max-width: 891px) 100vw, 891px\" \/><\/p>\n<h3 id=\"toc-hId--1816479333\"><em><strong>3. Detectors<\/strong><\/em><\/h3>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Some applications work better with an <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/industrial\/chromatography\/ion-chromatography-ic\/ic-chromatography-ic-detectors.html\" target=\"_blank\" rel=\"nofollow noopener\">alternative detector<\/a> such as nitrate and nitrite in the high presence of chloride.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Conductivity detection would be swamped with high levels of chloride masking the nitrate and nitrite peaks.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Nitrate and nitrite are UV active, chloride isn\u2019t and switching to a UV detector gives a cleaner response.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Other detectors can be linked to <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/chromatography\/ion-chromatography-ic.html\" target=\"_blank\" rel=\"noopener\">ion chromatographs<\/a>, such as <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/industrial\/mass-spectrometry\/ion-chromatography-mass-spectrometry-ic-ms.html\" target=\"_blank\" rel=\"nofollow noopener\">Mass Spectrometers<\/a> for unknowns and where higher resolution is required and also ICP-MS for <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/industrial\/chromatography\/ion-chromatography-ic\/ic-icp-ms-speciation-analyzer.html\" target=\"_blank\" rel=\"nofollow noopener\">speciation<\/a> of metals.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3 id=\"toc-hId--1787850182\"><em><strong>4. Method development from your desk<\/strong><\/em><\/h3>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>You don\u2019t always need to start a method from scratch with lots of lab work.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>We have a large range of applications ready to view in the free Thermo Scientific <a href=\"https:\/\/appslab.thermofisher.com\/\" target=\"_blank\" rel=\"nofollow noopener\">AppsLab Library of Analytical Applications.<\/a><\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Test out method conditions without even preparing a sample with our Free Online method simulator software <a href=\"https:\/\/appslab.thermofisher.com\/VirtualColumnOnline\" target=\"_blank\" rel=\"nofollow noopener\">Virtual Column<\/a>.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>This runs on known algorithms to predict behaviour of ions.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Select the column and conditions and create your separation.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Alter parameters such a temperature, eluent strength or change column in seconds.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><em>Use for isocratic and simple gradients, cations, anions and carbohydrates.<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-263\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-2.jpg\" alt=\"Image of virtual column simulation tool\" width=\"999\" height=\"743\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-2.jpg 999w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-2-300x223.jpg 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/5-Quick-Tips-to-Develop-and-Improve-Your-IC-Method-2-768x571.jpg 768w\" sizes=\"auto, (max-width: 999px) 100vw, 999px\" \/><\/p>\n<h3 id=\"toc-hId--1759221031\"><strong>5. Ask for help<\/strong><\/h3>\n<p>The final tip. We are always here to help. <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/global\/forms\/industrial\/contact-solutions-specialist.html\" target=\"_blank\" rel=\"nofollow noopener\">Contact<\/a> our specialists if you need to discuss applications.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimise conditions and not sure where to begin? This list is a<\/p>\n","protected":false},"author":1327,"featured_media":252,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17],"tags":[20],"division":[],"class_list":{"0":"post-250","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-ion-chromatography","8":"tag-ion-chromatography","9":"entry"},"_selected_authors":[1637],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>5 Quick Tips to Develop and Improve Your IC Method<\/title>\n<meta name=\"description\" content=\"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"5 Quick Tips to Develop and Improve Your IC Method\" \/>\n<meta property=\"og:description\" content=\"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/\" \/>\n<meta property=\"og:site_name\" content=\"AnalyteGuru\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ChromatographySolutions\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-24T14:14:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-13T00:15:37+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"879\" \/>\n\t<meta property=\"og:image:height\" content=\"734\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"AnalyteGuru Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ChromSolutions\" \/>\n<meta name=\"twitter:site\" content=\"@ChromSolutions\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"AnalyteGuru Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/\"},\"author\":{\"name\":\"AnalyteGuru Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/#\\\/schema\\\/person\\\/47226155467d66d692f24162ee320270\"},\"headline\":\"5 Quick Tips to Develop and Improve Your IC Method\",\"datePublished\":\"2019-07-24T14:14:02+00:00\",\"dateModified\":\"2026-05-13T00:15:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/\"},\"wordCount\":476,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/wp-content\\\/uploads\\\/sites\\\/25\\\/2023\\\/06\\\/3596-og.jpg\",\"keywords\":[\"Ion Chromatography\"],\"articleSection\":[\"Ion Chromatography\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/\",\"name\":\"5 Quick Tips to Develop and Improve Your IC Method\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/wp-content\\\/uploads\\\/sites\\\/25\\\/2023\\\/06\\\/3596-og.jpg\",\"datePublished\":\"2019-07-24T14:14:02+00:00\",\"dateModified\":\"2026-05-13T00:15:37+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/#\\\/schema\\\/person\\\/47226155467d66d692f24162ee320270\"},\"description\":\"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/wp-content\\\/uploads\\\/sites\\\/25\\\/2023\\\/06\\\/3596-og.jpg\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/wp-content\\\/uploads\\\/sites\\\/25\\\/2023\\\/06\\\/3596-og.jpg\",\"width\":879,\"height\":734},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/analyteguru\\\/5-quick-tips-to-develop-and-improve-your-ic-method\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"5 Quick Tips to Develop and Improve Your IC Method\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/\",\"name\":\"AnalyteGuru\",\"description\":\"Your educational resource for biopharma, pharma, environmental, food and agriculture, industrial, and clinical labs\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/analyteguru\\\/#\\\/schema\\\/person\\\/47226155467d66d692f24162ee320270\",\"name\":\"AnalyteGuru Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g\",\"caption\":\"AnalyteGuru Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/kerrycolligan\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"5 Quick Tips to Develop and Improve Your IC Method","description":"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/","og_locale":"en_US","og_type":"article","og_title":"5 Quick Tips to Develop and Improve Your IC Method","og_description":"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!","og_url":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/","og_site_name":"AnalyteGuru","article_publisher":"https:\/\/www.facebook.com\/ChromatographySolutions","article_published_time":"2019-07-24T14:14:02+00:00","article_modified_time":"2026-05-13T00:15:37+00:00","og_image":[{"width":879,"height":734,"url":"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","type":"image\/jpeg"}],"author":"AnalyteGuru Staff","twitter_card":"summary_large_image","twitter_creator":"@ChromSolutions","twitter_site":"@ChromSolutions","twitter_misc":{"Written by":"AnalyteGuru Staff","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/"},"author":{"name":"AnalyteGuru Staff","@id":"https:\/\/admin.acceleratingscience.com\/analyteguru\/#\/schema\/person\/47226155467d66d692f24162ee320270"},"headline":"5 Quick Tips to Develop and Improve Your IC Method","datePublished":"2019-07-24T14:14:02+00:00","dateModified":"2026-05-13T00:15:37+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/"},"wordCount":476,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","keywords":["Ion Chromatography"],"articleSection":["Ion Chromatography"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/","url":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/","name":"5 Quick Tips to Develop and Improve Your IC Method","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/analyteguru\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","datePublished":"2019-07-24T14:14:02+00:00","dateModified":"2026-05-13T00:15:37+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/analyteguru\/#\/schema\/person\/47226155467d66d692f24162ee320270"},"description":"Do you need to develop an Ion Chromatography (IC) method? Or are you struggling to optimize conditions and not sure where to begin? Start here!","breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","contentUrl":"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","width":879,"height":734},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/5-quick-tips-to-develop-and-improve-your-ic-method\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/analyteguru\/"},{"@type":"ListItem","position":2,"name":"5 Quick Tips to Develop and Improve Your IC Method"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/analyteguru\/#website","url":"https:\/\/admin.acceleratingscience.com\/analyteguru\/","name":"AnalyteGuru","description":"Your educational resource for biopharma, pharma, environmental, food and agriculture, industrial, and clinical labs","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/analyteguru\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/analyteguru\/#\/schema\/person\/47226155467d66d692f24162ee320270","name":"AnalyteGuru Staff","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d716c4c68d79e076572f67bcc11df0ef8db404f6c3463e9cfd3d20514a881439?s=96&d=mm&r=g","caption":"AnalyteGuru Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/kerrycolligan\/"}]}},"taxonomy_info":{"category":[{"value":17,"label":"Ion Chromatography"}],"post_tag":[{"value":20,"label":"Ion Chromatography"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg",760,635,false],"author_info":{"display_name":"AnalyteGuru Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/kerrycolligan\/"},"comment_info":0,"category_info":[{"term_id":17,"name":"Ion Chromatography","slug":"ion-chromatography","term_group":0,"term_taxonomy_id":17,"taxonomy":"category","description":"","parent":0,"count":70,"filter":"raw","meta":[],"cat_ID":17,"category_count":70,"category_description":"","cat_name":"Ion Chromatography","category_nicename":"ion-chromatography","category_parent":0}],"tag_info":[{"term_id":20,"name":"Ion Chromatography","slug":"ion-chromatography","term_group":0,"term_taxonomy_id":20,"taxonomy":"post_tag","description":"","parent":0,"count":75,"filter":"raw","meta":[]}],"jetpack_sharing_enabled":true,"jetpack-related-posts":[],"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/3596-og.jpg","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/posts\/250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/users\/1327"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/comments?post=250"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/posts\/250\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/media\/252"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/media?parent=250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/categories?post=250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/tags?post=250"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/wp-json\/wp\/v2\/division?post=250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}