
{"id":4511,"date":"2021-01-03T00:00:00","date_gmt":"2021-01-03T00:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/mass-spec-goes-mainstream\/"},"modified":"2024-04-18T23:15:47","modified_gmt":"2024-04-18T23:15:47","slug":"mass-spec-goes-mainstream","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/analyteguru\/mass-spec-goes-mainstream\/","title":{"rendered":"Mass Spec Goes Mainstream"},"content":{"rendered":"<div class=\"lia-message-body-content\">\n<h3 id=\"toc-hId--1902364864\">High-performance biopharmaceutical characterization for everyone!<\/h3>\n<p>I&#8217;ve just recently celebrated five years in my current role here at Thermo Fisher Scientific. Wow, where did those years go? I love what I do, but it does mean that it&#8217;s been five whole years since I had my very own mass spectrometer to look after. Although mass spectrometry is still very much part of my life, I do miss being greeted each morning with the green lights of my Orbitrap.<\/p>\n<h3 id=\"toc-hId--1902364864\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-11370 alignright\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121.jpg\" alt=\"\" width=\"446\" height=\"297\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121.jpg 1200w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121-300x200.jpg 300w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121-1024x683.jpg 1024w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121-768x512.jpg 768w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage1_030121-96x65.jpg 96w\" sizes=\"auto, (max-width: 446px) 100vw, 446px\" \/><\/h3>\n<p>In all honesty, my fifteen or so years working with MS, haven&#8217;t all been plain sailing! There&#8217;s been late nights and lost weekends spent in the lab, trying to get things to work and more than a couple of naughty words muttered under my breath. One thing is for sure as the years pass, MS becomes more and more user-friendly. This seems especially apparent in the last few years.<\/p>\n<p>Take the Thermo Scientific <a href=\"https:\/\/www.thermofisher.com\/uk\/en\/home\/industrial\/mass-spectrometry\/liquid-chromatography-mass-spectrometry-lc-ms\/lc-ms-systems\/orbitrap-lc-ms\/orbitrap-exploris-mass-spectrometers\/orbitrap-exploris-240-mass-spectrometers.html\" target=\"_blank\" rel=\"nofollow noopener\">Orbitrap Exploris 240 mass spectrometer<\/a>, a fourth-generation hybrid quadrupole-Orbitrap mass spectrometer benefiting from over twenty years of engineering experience. The platform provides simplification of operational procedures and high-performance biopharmaceutical characterization accessible to everyone.<\/p>\n<p>With superb spectral clarity, the <a href=\"https:\/\/assets.thermofisher.com\/TFS-Assets\/CMD\/brochures\/br-73410-ms-orbitrap-exploris-240-br73410-en.pdf\" target=\"_blank\" rel=\"nofollow noopener\">Orbitrap Exploris 240<\/a> delivers the high-confidence characterization required to reliably quantitate and identify biotherapeutics in both research and routine laboratory environments. From intact mass analysis under denaturing and native conditions to subunit analysis, middle- and top-down analysis, and peptide or disulfide bond mapping; it maximizes productivity through improved flexibility, speed and dependability.<\/p>\n<p>Discover how the Orbitrap Exploris 240 is an ideal instrument platform for performing MS analysis of intact biopharmaceuticals under native conditions. Utilizing <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/pharma-biopharma\/biopharmaceutical-analytical-testing\/intact-protein-analysis-workflows\/charge-variant-analysis.html\" target=\"_blank\" rel=\"noopener\">charge variant<\/a> analysis, the platform enables in-depth characterization and confident identification of mAb microheterogeneity due to excellent sensitivity and spectral quality.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-11378\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage2_030121.jpg.png\" alt=\"\" width=\"508\" height=\"647\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage2_030121.jpg.png 508w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage2_030121.jpg-236x300.png 236w\" sizes=\"auto, (max-width: 508px) 100vw, 508px\" \/><\/p>\n<p>See how these latest advances in high-resolution accurate-mass (HRAM) MS can be deployed to pinpoint site-specific identification of oxidation hotspots in therapeutic proteins and detect with confidence low-level methionine oxidation through diagnostic MS\/MS fragmentation at the peptide level.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-11364\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage3_030121.jpg.png\" alt=\"\" width=\"502\" height=\"647\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage3_030121.jpg.png 502w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage3_030121.jpg-233x300.png 233w\" sizes=\"auto, (max-width: 502px) 100vw, 502px\" \/><\/p>\n<p>Find out how the system delivers operational simplicity and walk-up performance without the requirement for complex setup and tuning procedures.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-11366\" src=\"http:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage4_030121.jpg.png\" alt=\"\" width=\"500\" height=\"653\" srcset=\"https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage4_030121.jpg.png 500w, https:\/\/admin.acceleratingscience.com\/analyteguru\/wp-content\/uploads\/sites\/25\/2023\/06\/BlogImage4_030121.jpg-230x300.png 230w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<h3 id=\"toc-hId--1873735713\">On-demand webinars featuring the new platform:<\/h3>\n<p><a href=\"https:\/\/event.on24.com\/eventRegistration\/EventLobbyServlet?target=reg20.jsp&amp;partnerref=linkedInShareFromReg&amp;ms=1612884128835&amp;eventid=2990354&amp;sessionid=1&amp;key=636BFCD56C948B1E3E7317D48D7C991C&amp;regTag=2040498&amp;V2=false&amp;sourcepage=register\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">https:\/\/event.on24.com\/eventRegistration\/EventLobbyServlet?target=reg20.jsp&amp;partnerref=linkedInShare&#8230;<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>High-performance biopharmaceutical characterization for everyone! I\u00e2\u0080\u0099ve just recently celebrated five years in my current role here at Thermo Fisher<\/p>\n","protected":false},"author":1327,"featured_media":4513,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[38,22],"tags":[41,24],"division":[],"class_list":{"0":"post-4511","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-biopharmaceutical","8":"category-orbitrap","9":"tag-biopharmaceutical","10":"tag-orbitrap","11":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mass Spec Goes Mainstream<\/title>\n<meta name=\"description\" content=\"High-performance biopharmaceutical characterization for everyone! 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