{"id":1076,"date":"2023-04-13T09:16:37","date_gmt":"2023-04-13T09:16:37","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/?p=1076"},"modified":"2023-11-27T18:50:23","modified_gmt":"2023-11-27T18:50:23","slug":"mitochondrial-dysfunction-cryo-electron-tomography","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/","title":{"rendered":"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute"},"content":{"rendered":"<h2 style=\"font-size: 100%\"><strong>What is mitochondrial dysfunction?<\/strong><\/h2>\n<p>Often referred to as \u201cthe powerhouse of the cell,\u201d mitochondria carry out a wide range of functions critical to cellular health. Yet mitochondrial dysfunction can contribute to hundreds of human diseases from cancer to Alzheimer\u2019s, Parkinson\u2019s and mental disorders such as schizophrenia.<\/p>\n<p>Until recently, studies of the ultrastructural details of mitochondria have been limited, especially for statistical studies. Scientists at Scripps Research Institute are combining <a href=\"https:\/\/ter.li\/x5rxnm\">cryo-electron tomography<\/a> with a novel computational method to compare their functional differences\u2014leading to new breakthroughs in mitochondria research.<\/p>\n<p>We had the opportunity to discuss these efforts with Danielle Grotjahn, PhD, assistant professor in the Department of Integrative and Computational Biology and Luke Wiseman, PhD, professor in the Department of Molecular Medicine at Scripps Research Institute.<\/p>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/MdAxI6PZWmw?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span><\/p>\n<h2 style=\"font-size: 100%\"><strong>Deconvoluting mitochondrial dysfunction and disease<\/strong><\/h2>\n<p>Dr. Grotjahn heads up the Grotjahn Lab where her team studies the functional and structural interactions that mediate stress-induced modulations to mitochondrial networks.<\/p>\n<p>By using a variety of techniques at the intersection of cellular, molecular, and structural biology, and collaborating cross functionally on mitochondria research with other Scripps Research scientists, including Dr. Wiseman, the lab aims to advance the world\u2019s understanding of physiological and pathogenic mechanisms that contribute to mitochondrial dysfunction and disease.<\/p>\n<p>First, the Grotjahn Lab embraced cryo-electron tomography, cryo-focused ion beam milling and correlative light and electron microscopy to obtain detailed 3D images of mitochondria at nanometer resolution.<\/p>\n<p>\u201cWe want to know how all the parts come together,\u201d said Dr. Grotjahn during her interview with Thermo Fisher Scientific. \u201cThat\u2019s where cryo-electron tomography really shines because it\u2019s one of the few techniques that allows us to look at not only the details of the individual parts, but also all of them holistically together.\u201d<\/p>\n<p>They also value the use of cryo-electron tomography along with other imaging modalities, \u201cto really get that whole picture across scales,\u201d she said. \u201cI think this will be really useful for other applications in cell biology. Pretty much any cellular process you can imagine is dynamic and has lots of different scales and lots of different parts to it. Being able to image on a cellular and molecular level is really going to transform the field of cell biology.\u201d<\/p>\n<h2 style=\"font-size: 100%\"><strong>No two cells are alike: the case for more statistical measurements<\/strong><\/h2>\n<p>Dr. Grotjahn\u2019s and Dr. Wiseman\u2019s teams <a href=\"https:\/\/www.genengnews.com\/imaging\/microscopy\/novel-imaging-toolkit-unveils-detailed-structure-of-mitochondria\/\">recently introduced a novel computational toolkit<\/a> to help rapidly process these images, turning them into precise measurements that could eventually shed new light on the physiological and pathogenic mechanisms that contribute to mitochondrial dysfunction and disease.<\/p>\n<p>Their \u2018surface morphometrics toolkit\u2019 enables the detailed mapping and measurement of the structural elements of individual mitochondria, because no two cells are alike.<\/p>\n<p>\u201cThe big question is what can you measure in a tomogram,\u201d said Dr. Wiseman. \u201cThere are the things you can see with your eye that strike you very quickly [like] mitochondria cristae for example . . . Next, you have to understand what\u2019s really different about them. Not just, \u2018they look different.\u2019 That\u2019s not good enough. You have to be able to say, \u2018This curvature is different, the junctions are different, the width of the cristae are different.\u2019\u201d<\/p>\n<p>According to Dr. Wiseman, there were many cases where they\u2019d have to manually draw or model what the different membranes looked like to get these types of measurements.<\/p>\n<p>\u201cDanielle found solutions around some of these problems, where now we&#8217;re getting discrete measurements,\u201d he said. \u201cWe&#8217;re getting those junction curvatures; we&#8217;re getting cristae widths.\u201d<\/p>\n<p>Combining cryo-electron tomography with this computational method is proving successful for these groups studying the structural differences between mitochondria in cells that are functioning properly to those within cells under stress.<\/p>\n<p>\u201cThe key thing for us to really apply this sort of technology was to be able to develop higher throughput strategies, where we can have multiple different images,\u201d said Dr. Wiseman. \u201cWe have to be able to have enough images to we can get statistical significance between differences.\u201d<\/p>\n<h2 style=\"font-size: 100%\"><strong>Disrupting mitochondrial diseases<\/strong><\/h2>\n<p>Most recently, the team used this combination to pinpoint the structural changes that occur <a href=\"https:\/\/www.genengnews.com\/imaging\/microscopy\/novel-imaging-toolkit-unveils-detailed-structure-of-mitochondria\/\">when mitochondria are subjected to cellular stresses<\/a> induced by diseases, toxins, infections, and pharmaceutical drugs.<\/p>\n<p>\u201cWhat we\u2019re trying to do is figure out how our bodies are naturally protecting themselves from different types of pathological insults, things that are associated with different types of diseases,\u201d said Dr. Wiseman. \u201cIf we understand how those pathways work, we can find ways to actually hijack them. And by hijacking them, we can develop new therapeutics to intervene in disease.\u201d<\/p>\n<p>Dr. Grotjahn is very excited about the <a href=\"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/whats-possible-cryo-electron-tomography\/\">future of cryo-electron tomography<\/a>, and it shows.<\/p>\n<p>\u201cWhat&#8217;s really exciting about Scripps is that we are equipped with everything that we need to dive into cells and be able to visualize them in a completely new way and with extreme detail. The infrastructure we have here really allows us to do this at a throughput that enables us to make important biological discoveries more quickly and more streamlined,\u201d she said.<\/p>\n<p><em><a href=\"https:\/\/rupress.org\/jcb\/article-abstract\/222\/4\/e202204093\/213869\/Quantifying-organellar-ultrastructure-in-cryo?redirectedFrom=fulltext\">Read Dr. Grotjahn\u2019s and Dr. Wiseman\u2019s recent article published in the Journal of Cell Biology &gt;&gt; <\/a><\/em><\/p>\n<p><em>\/\/<\/em><\/p>\n<p><em>Leah Lavery is a Sr. Manager, Life Sciences Market Development at Thermo Fisher Scientific.<\/em><\/p>\n<p><a href=\"https:\/\/ter.li\/3eej7j\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1336\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/10\/Optin-Banner_Oct-2023-v2.png\" alt=\"Subscribe to electron microscopy updates and content from Thermo Fisher Scientific\" width=\"1000\" height=\"176\" srcset=\"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/10\/Optin-Banner_Oct-2023-v2.png 1000w, https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/10\/Optin-Banner_Oct-2023-v2-300x53.png 300w, https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/10\/Optin-Banner_Oct-2023-v2-768x135.png 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is mitochondrial dysfunction? Often referred to as \u201cthe powerhouse of the cell,\u201d mitochondria carry out a wide range of functions critical to cellular health. Yet mitochondrial dysfunction can contribute to hundreds of human diseases from cancer to Alzheimer\u2019s, Parkinson\u2019s and mental disorders such as schizophrenia. Until recently, studies of the ultrastructural details of mitochondria<\/p>\n","protected":false},"author":1191,"featured_media":1079,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[128,51,33],"tags":[15,129,16],"division":[],"class_list":{"0":"post-1076","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cryo-electron-tomography","8":"category-customer-spotlights","9":"category-general","10":"tag-cryo-electron-microscopy","11":"tag-cryo-electron-tomography","12":"tag-cryo-em","13":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Mitochondrial Dysfunction - Cryo-ET - Life in Atomic Resolution<\/title>\n<meta name=\"description\" content=\"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute\" \/>\n<meta property=\"og:description\" content=\"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/\" \/>\n<meta property=\"og:site_name\" content=\"Life in Atomic Resolution\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-13T09:16:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-27T18:50:23+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Leah Lavery\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Leah Lavery\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/\"},\"author\":{\"name\":\"Leah Lavery\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/9446d1591418a0d5dcb708243733adff\"},\"headline\":\"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute\",\"datePublished\":\"2023-04-13T09:16:37+00:00\",\"dateModified\":\"2023-11-27T18:50:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/\"},\"wordCount\":885,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2023\\\/04\\\/Scripps-cryo-et-social.png\",\"keywords\":[\"cryo-electron microscopy\",\"cryo-electron tomography\",\"cryo-EM\"],\"articleSection\":[\"Cryo-Electron Tomography\",\"Customer Spotlights\",\"General\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/\",\"name\":\"Mitochondrial Dysfunction - Cryo-ET - Life in Atomic Resolution\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2023\\\/04\\\/Scripps-cryo-et-social.png\",\"datePublished\":\"2023-04-13T09:16:37+00:00\",\"dateModified\":\"2023-11-27T18:50:23+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/9446d1591418a0d5dcb708243733adff\"},\"description\":\"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2023\\\/04\\\/Scripps-cryo-et-social.png\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2023\\\/04\\\/Scripps-cryo-et-social.png\",\"width\":1200,\"height\":630,\"caption\":\"The study of mitochondrial dysfunction at Scripps Research Institute\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/atomic-resolution\\\/mitochondrial-dysfunction-cryo-electron-tomography\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/\",\"name\":\"Life in Atomic Resolution\",\"description\":\"Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/9446d1591418a0d5dcb708243733adff\",\"name\":\"Leah Lavery\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g\",\"caption\":\"Leah Lavery\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/leahlavery\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Mitochondrial Dysfunction - Cryo-ET - Life in Atomic Resolution","description":"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/","og_locale":"en_US","og_type":"article","og_title":"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute","og_description":"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.","og_url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/","og_site_name":"Life in Atomic Resolution","article_publisher":"https:\/\/www.facebook.com\/thermofisher","article_published_time":"2023-04-13T09:16:37+00:00","article_modified_time":"2023-11-27T18:50:23+00:00","og_image":[{"width":1200,"height":630,"url":"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","type":"image\/png"}],"author":"Leah Lavery","twitter_card":"summary_large_image","twitter_creator":"@thermofisher","twitter_site":"@thermofisher","twitter_misc":{"Written by":"Leah Lavery","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/"},"author":{"name":"Leah Lavery","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/9446d1591418a0d5dcb708243733adff"},"headline":"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute","datePublished":"2023-04-13T09:16:37+00:00","dateModified":"2023-11-27T18:50:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/"},"wordCount":885,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","keywords":["cryo-electron microscopy","cryo-electron tomography","cryo-EM"],"articleSection":["Cryo-Electron Tomography","Customer Spotlights","General"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/","url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/","name":"Mitochondrial Dysfunction - Cryo-ET - Life in Atomic Resolution","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","datePublished":"2023-04-13T09:16:37+00:00","dateModified":"2023-11-27T18:50:23+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/9446d1591418a0d5dcb708243733adff"},"description":"Scripps Research Institute scientists use cryo-electron tomography to study role of mitochondrial dysfunction in hundreds of human diseases.","breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","contentUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","width":1200,"height":630,"caption":"The study of mitochondrial dysfunction at Scripps Research Institute"},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/mitochondrial-dysfunction-cryo-electron-tomography\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/"},{"@type":"ListItem","position":2,"name":"Cryo-ET Sheds New Light on Mitochondrial Dysfunction at Scripps Research Institute"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#website","url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/","name":"Life in Atomic Resolution","description":"Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/9446d1591418a0d5dcb708243733adff","name":"Leah Lavery","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/556fbf75b49a1d49dbcca690062552894d5854740ff1464e6b4d5b2500756b21?s=96&d=mm&r=g","caption":"Leah Lavery"},"url":"https:\/\/admin.acceleratingscience.com\/author\/leahlavery\/"}]}},"taxonomy_info":{"category":[{"value":128,"label":"Cryo-Electron Tomography"},{"value":51,"label":"Customer Spotlights"},{"value":33,"label":"General"}],"post_tag":[{"value":15,"label":"cryo-electron microscopy"},{"value":129,"label":"cryo-electron tomography"},{"value":16,"label":"cryo-EM"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social-1024x538.png",760,399,true],"author_info":{"display_name":"Leah Lavery","author_link":"https:\/\/admin.acceleratingscience.com\/author\/leahlavery\/"},"comment_info":0,"category_info":[{"term_id":128,"name":"Cryo-Electron Tomography","slug":"cryo-electron-tomography","term_group":0,"term_taxonomy_id":128,"taxonomy":"category","description":"","parent":24,"count":16,"filter":"raw","meta":[],"cat_ID":128,"category_count":16,"category_description":"","cat_name":"Cryo-Electron Tomography","category_nicename":"cryo-electron-tomography","category_parent":24},{"term_id":51,"name":"Customer Spotlights","slug":"customer-spotlights","term_group":0,"term_taxonomy_id":51,"taxonomy":"category","description":"","parent":0,"count":36,"filter":"raw","meta":[],"cat_ID":51,"category_count":36,"category_description":"","cat_name":"Customer Spotlights","category_nicename":"customer-spotlights","category_parent":0},{"term_id":33,"name":"General","slug":"general","term_group":0,"term_taxonomy_id":33,"taxonomy":"category","description":"","parent":0,"count":59,"filter":"raw","meta":[],"cat_ID":33,"category_count":59,"category_description":"","cat_name":"General","category_nicename":"general","category_parent":0}],"tag_info":[{"term_id":15,"name":"cryo-electron microscopy","slug":"cryo-electron-microscopy","term_group":0,"term_taxonomy_id":15,"taxonomy":"post_tag","description":"","parent":0,"count":62,"filter":"raw","meta":[]},{"term_id":129,"name":"cryo-electron tomography","slug":"cryo-electron-tomography","term_group":0,"term_taxonomy_id":129,"taxonomy":"post_tag","description":"","parent":0,"count":15,"filter":"raw","meta":[]},{"term_id":16,"name":"cryo-EM","slug":"cryo-em","term_group":0,"term_taxonomy_id":16,"taxonomy":"post_tag","description":"","parent":0,"count":63,"filter":"raw","meta":[]}],"jetpack-related-posts":[{"id":2117,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/advances-in-cryo-electron-tomography-expand-the-capabilities-of-quantitative-cell-biology\/","url_meta":{"origin":1076,"position":0},"title":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology","author":"Vinay S","date":"September 29, 2026","format":false,"excerpt":"Key takeaways Cryo-electron tomography has largely been seen as a qualitative method because cryo-ET data segmentation has been a highly intensive, manual process. Recent advances in deep-learning-based segmentation have expanded the capabilities of cryo-electron tomography, supporting quantitative analysis of cellular structures. A recent webinar by Professor Danielle Grotjahn highlights how\u2026","rel":"","context":"In &quot;Cryo EM Techniques&quot;","block_context":{"text":"Cryo EM Techniques","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-techniques\/"},"img":{"alt_text":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2172,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/what-is-subtomogram-averaging\/","url_meta":{"origin":1076,"position":1},"title":"What is Subtomogram Averaging?","author":"Swarnim Rawat","date":"October 19, 2026","format":false,"excerpt":"Turning crowded cryo-ET data into structural insight with subtomogram averaging Cryo-electron tomography (cryo-ET) is capable of capturing detailed, three-dimensional views of vitrified biological samples, supporting a broad range of life sciences research. Subtomogram averaging helps refine that crowded data for clearer structural insight by finding repeated particles, extracting them as\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/cancer-research\/"},"img":{"alt_text":"Social Cryo EM","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1854,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/advances-in-100-kv-high-resolution-cryo-em-single-particle-analysis\/","url_meta":{"origin":1076,"position":2},"title":"Advances in high-resolution cryo-EM at 100 kV","author":"Swarnim Rawat","date":"February 5, 2026","format":false,"excerpt":"100 kV cryo-TEM enables high-resolution single particle analysis Within the past decade, cryo-electron microscopy (cryo-EM) techniques have revolutionized structural biology by enabling the visualization of challenging molecular and sub-cellular structures in their near-native states at high resolution. These valuable observations have, until recently, been relegated to advanced 300 kV instruments\u2026","rel":"","context":"In &quot;Cryo-Electron Microscopy (Cryo-EM)&quot;","block_context":{"text":"Cryo-Electron Microscopy (Cryo-EM)","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/"},"img":{"alt_text":"Advances in high-resolution cryo-EM at 100 kV","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1935,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/fragment-based-drug-discovery-of-drug-targets-membrane-proteins-with-cryo-em\/","url_meta":{"origin":1076,"position":3},"title":"Fragment based drug discovery meets challenging drug targets with high-throughput cryo-EM\u00a0","author":"Swarnim Rawat","date":"December 12, 2025","format":false,"excerpt":"Benefits of FBDD in the search for novel therapeutics\u00a0 Fragment-based drug discovery (FBDD) is a method that screens a large quantity of protein fragments for their potential as small molecule therapeutics. This approach was previously hampered by the slow throughput of crystallization for the characterization of potential leads. The increasing\u2026","rel":"","context":"In &quot;Cryo EM Drug Discovery&quot;","block_context":{"text":"Cryo EM Drug Discovery","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-drug-discovery\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2143,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/microscopy-image-analysis-with-amira-software-ai-in-cell-biology\/","url_meta":{"origin":1076,"position":4},"title":"Four ways AI is making microscopy image analysis easier for cell biologists","author":"Alejandra Sanchez-Erostegui","date":"October 14, 2026","format":false,"excerpt":"Key takeaways Modern microscopes are capable of generating large volumes of high-resolution data, which is highly valuable for cell biology research, but also makes it increasingly more laborious and difficult to extract meaningful scientific information from the whole dataset.\u00a0 Artificial intelligence is well positioned to support this work by streamlining\u2026","rel":"","context":"In &quot;Amira Software&quot;","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"Four ways AI is making microscopy image analysis easier for cell biologists.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2071,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/facilitating-soft-tissue-analysis-unraveling-complex-microct-imaging-data-with-amira-software\/","url_meta":{"origin":1076,"position":5},"title":"Facilitating Soft Tissue Analysis \u2013 Unraveling Complex MicroCT Imaging Data with Amira Software","author":"Vinay S","date":"August 27, 2026","format":false,"excerpt":"Key takeaways Micro-computed X-ray tomography (microCT) can be used for high-resolution, 3D visualization of a range of biological samples, including soft tissues, but transforming this data into scientific insights requires the processing of increasingly large, complex datasets. Thermo Scientific Amira Software is a powerful data processing tool that can simplify\u2026","rel":"","context":"In &quot;Amira Software&quot;","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"Facilitating Soft Tissue Analysis \u2013 Unraveling Complex MicroCT Imaging Data with Amira Software","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/08\/blog-soft-tissue-micro-ct-research-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2023\/04\/Scripps-cryo-et-social.png","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/1076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/users\/1191"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/comments?post=1076"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/1076\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media\/1079"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media?parent=1076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/categories?post=1076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/tags?post=1076"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/division?post=1076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}