{"id":552,"date":"2021-04-26T08:38:09","date_gmt":"2021-04-26T08:38:09","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/2021\/04\/26\/cryo-em-access-on-the-rise\/"},"modified":"2021-04-26T08:38:09","modified_gmt":"2021-04-26T08:38:09","slug":"cryo-em-access-on-the-rise","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/cryo-em-access-on-the-rise\/","title":{"rendered":"Cryo-EM Access On the Rise During 50th Anniversary of Protein Data Bank"},"content":{"rendered":"
\"Cryo-EM<\/a>

See key cryo-EM structures submitted to the Protein Data Bank on Twitter<\/a>.<\/p><\/div>\n

This year, the\u00a0Protein Data Bank<\/a>\u00a0celebrates\u00a0its 50th\u00a0anniversary while cryo-electron microscopy<\/a> (cryo-EM) continues to rise in prominence as the go-to technique for solving biological structures at high-resolution. Thanks in part to increased cryo-EM access, the total number of solved structures added to this single worldwide archive grew fivefold over the past two decades<\/a>.<\/p>\n

In that time, the number of structures added via electron microscopy\u00a0alone\u00a0grew\u00a0by nearly 17,000%.\u00a0In 2020, 2,390 structures solved using cryo-EM were added to the archive\u2014a 65%\u00a0jump over the previous year\u00a0and\u00a015% of all structures submitted\u00a0that year.<\/p>\n

Cryo-EM ushered\u00a0in a new era<\/a>\u00a0of structural biology with its ability to view molecules in their near-native state at atomic-level resolution. The method\u00a0became\u00a0the second most widely used technique for solving structures added to the Protein Data Bank,\u00a0surpassing\u00a0nuclear magnetic resonance (NMR)\u00a0in\u00a02017.<\/p>\n

Cryo-EM\u00a0also\u00a0gained\u00a0ground on\u00a0the No. 1 method to-date\u2014X-ray crystallography\u2014which\u00a0faces limits in its\u00a0ability\u00a0to\u00a0crystallize\u00a0macromolecules of large size and poor\u00a0stability.<\/p>\n

Cryo-EM access\u00a0<\/span><\/b>through innovative instrumentation<\/span><\/b>\u00a0<\/span><\/h2>\n

As cryo-<\/span>EM continues its ascent,\u00a0<\/span>it<\/span>\u00a0i<\/span>s important to callout the\u00a0<\/span>cutting-edge<\/span>\u00a0equipment that made it pos<\/span>sible.\u00a0<\/span>\u00a0<\/span><\/p>\n

Thanks to their speed, accuracy, and high-resolution results, our\u00a0Thermo Scientific\u00a0Glacios\u00a0Cryo-TEM<\/a>,\u00a0Krios\u00a0Cryo-TEM<\/a>, and\u00a0Talos Arctica Cryo-TEM<\/a>\u00a0contribute to the\u00a0structures solved\u00a0using\u00a0cryo-EM\u00a0and\u00a0lead\u00a0to important discoveries that increase\u00a0our\u00a0understanding of\u00a0a wide range of diseases from\u00a0HIV\u00a0to cancer to neurodegenerative diseases\u00a0like Alzheimer\u2019s or Parkinson\u2019s.<\/p>\n

\"Captured

This is the first cryo-EM structure of the SARS-CoV-2 spike protein<\/a>. The rapid mapping of this structure led to subsequent drug development.<\/p><\/div>\n

Moreover,\u00a0related techniques\u00a0such as\u00a0cryo-electron tomography<\/a>\u00a0(cryo-ET)\u00a0revolutionized\u00a0biomedical research by making it\u00a0possible to visualize\u00a03D\u00a0protein structures\u00a0and\u00a0disease states\u00a0within the context of the larger cell.<\/p>\n

Adopting cryo-EM<\/b><\/h2>\n
\"Captured

One of the highest resolution structures deposited: adeno-associated virus, the leading viral vector for gene therapy.<\/p><\/div>\n

While cryo-EM has come a long way, realizing the full<\/span>\u00a0potential of\u00a0<\/span>this technique<\/span>\u00a0will require a far greater level of adoption<\/span>. Whether it be new diseases and viruses or a changing environment that puts new strains on\u00a0<\/span>agricultural\u00a0<\/span>crops,\u00a0<\/span>far more\u00a0<\/span>scientists<\/span>\u00a0in\u00a0<\/span>many<\/span>\u00a0<\/span>research areas\u00a0<\/span>need access to<\/span>\u00a0cryo-EM technologies to<\/span>\u00a0tackle<\/span>\u00a0<\/span>the<\/span>\u00a0evolving set of\u00a0<\/span>challenges in front of\u00a0<\/span>them<\/span>.\u00a0<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

At <\/span>Thermo\u00a0<\/span>Fisher<\/span>, we<\/span>\u00a0made\u00a0<\/span>cryo-EM access\u00a0<\/span>and the\u00a0<\/span>democratiz<\/span>ation of<\/span>\u00a0this technique<\/span>\u00a0<\/span>a priority<\/span>.<\/span>\u00a0<\/span>O<\/span>ur\u00a0<\/span>groundbreaking<\/span>\u00a0<\/span>Thermo Scientific Tundra<\/span>\u00a0Cryo-TEM<\/span><\/a>,\u00a0<\/span>which\u00a0<\/span>was released at the close of 2020,\u00a0<\/span>broaden<\/span>s<\/span>\u00a0<\/span>cryo-EM access<\/span>\u00a0<\/span>by delivering unprecedented ease of use at an affordable price.\u00a0<\/span>This more accessible cryo-TEM<\/span>\u00a0uses\u00a0<\/span>artificial intelligence\u00a0<\/span>and guided automation to bring cryo-EM to non-expert users\u2014helping them\u00a0<\/span>to\u00a0<\/span>easily navigate what was once a complex workflow<\/span>\u00a0<\/span>while achieving<\/span>\u00a0resolutions as high as\u00a0<\/span>3.5 angstrom<\/span>.\u00a0<\/span> As the world\u00a0<\/span>confronts a growing number of<\/span>\u00a0challenges, greater\u00a0<\/span>cryo-EM access\u00a0<\/span>remains<\/span>\u00a0a top priority<\/span>.\u00a0<\/span>By democratizing cryo-EM, our goal is to speed the path to\u00a0<\/span>important scientific discoveries<\/span>\u00a0by\u00a0<\/span>making\u00a0<\/span>cryo-EM affordable and\u00a0<\/span>seamless\u00a0<\/span>for every biochemistry laboratory to\u00a0<\/span>use.<\/span>\u00a0<\/span><\/div>\n

\u00a0\/\/<\/span><\/p>\n

Jeffrey Lengyel, Ph.D., is\u00a0<\/span><\/i>Principal Scientist of Life Sciences at<\/span><\/i>\u00a0Thermo Fisher Scientific.<\/span><\/i> To learn more about the breakthrough impacts of cryo-EM, visit\u00a0our\u00a0Life Sciences Electron Microscopy Learning Center<\/a>.\u00a0\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

This year, the\u00a0Protein Data Bank\u00a0celebrates\u00a0its 50th\u00a0anniversary while cryo-electron microscopy (cryo-EM) continues to rise in prominence as the go-to technique for solving biological structures at high-resolution. Thanks in part to increased cryo-EM access, the total number of solved structures added to this single worldwide archive grew fivefold over the past two decades. In that time, the<\/p>\n","protected":false},"author":850,"featured_media":429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[24,33],"tags":[15,16],"division":[],"class_list":{"0":"post-552","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cryo-electron-microscopy-cryo-em","8":"category-general","9":"tag-cryo-electron-microscopy","10":"tag-cryo-em","11":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\nCryo-EM 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