{"id":646,"date":"2022-01-11T10:10:34","date_gmt":"2022-01-11T10:10:34","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/2022\/01\/11\/cryo-em-pathogenic-virus-research-biosafety-level-3\/"},"modified":"2024-04-12T17:20:43","modified_gmt":"2024-04-12T17:20:43","slug":"cryo-em-pathogenic-virus-research-biosafety-level-3","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/cryo-em-pathogenic-virus-research-biosafety-level-3\/","title":{"rendered":"New Krios Cryo-TEM Solution to Enable Whole Virus Research in Higher Biosafety Level Labs"},"content":{"rendered":"<h2 style=\"font-size: 100%\"><strong>Pathogenic\u00a0virus research: unanswered questions\u00a0<\/strong><\/h2>\n<p>Cryo-electron microscopy (cryo-EM) has been used to study viral pathogens for more than 20 years, resolving the structures of viruses such as\u00a0<a href=\"https:\/\/ter.li\/v7e0di\">Zika, Ebola, HIV, and\u00a0coronaviruses<\/a>.<\/p>\n<p>During\u00a0the COVID-19 pandemic, cryo-EM played a pivotal role in <a href=\"https:\/\/admin.acceleratingscience.com\/microscopy\/amira-software-coronavirus-research\/\">accelerating vaccine development\u00a0and\u00a0antiviral drug discovery<\/a>\u00a0for\u00a0this newly emerging pathogen.<\/p>\n<p>Despite the achievements of\u00a0virus research, many\u00a0viral pathogens\u00a0have yet\u00a0to be\u00a0studied, and questions about their\u00a0behavior\u00a0remain unanswered.\u00a0Structural virology\u00a0provides\u00a0critical insights into\u00a0virus\u00a0morphology, life cycle, and interactions with host cells, enabling researchers to address these fundamental questions.<\/p>\n<h2 style=\"font-size: 100%\"><strong>Furthering the scope of structural virology\u00a0<\/strong><\/h2>\n<p>Presently, only few\u00a0high-end cryo-EM instruments\u00a0are available in biosafety level 3\u00a0labs. This means\u00a0structural\u00a0virology research is\u00a0often\u00a0restricted to isolated proteins, inactivated samples or\u00a0substituted\u00a0non-risk model systems\u2014in other words,\u00a0those deemed safe for lower biosafety environments.<\/p>\n<p>Yet, scientists\u00a0around the world\u00a0have\u00a0an\u00a0increasing\u00a0desire\u00a0to study viral pathogens in their native\u00a0state.<\/p>\n<p>Therefore,\u00a0we\u2019ve set out to offer<a href=\"https:\/\/ter.li\/vi31c0\"> solutions\u00a0that will allow\u00a0cryo-EM installations in higher-level biosafety\u00a0facilities<\/a>\u00a0(e.g.,\u00a0biosafety level 3)\u00a0\u2014\u00a0to\u00a0broaden the scope of samples that can be worked on while assuring\u00a0the\u00a0performance\u00a0and serviceability\u00a0of the microscopes.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2114 size-full aligncenter\" title=\"Virus research in higher biosafety level labs\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/04\/Untitled-design-1.jpg\" alt=\"Virus research in higher biosafety level labs\" width=\"1200\" height=\"630\" \/><\/p>\n<h2 style=\"font-size: 100%\"><strong>Our new 60\u00b0C heat decontamination solution\u00a0for the\u00a0Krios\u00a0G4\u00a0Cryo-TEM<\/strong><\/h2>\n<p>We have a long history of working with\u00a0scientists\u00a0to create customized instruments that\u00a0support their research endeavors in the field of structural virology.<\/p>\n<p>Over the years, we have also adapted our protocols, processes, and training to support the operation and service of our instruments in\u00a0biosafety level 1, 2, and 3\u00a0environments.<\/p>\n<p>In 2019, we saw our very own\u00a0Applications Development Laboratory\u00a0in Brno, Czech Republic\u00a0certified\u00a0for\u00a0biosafety level\u00a02 operation.\u00a0This lab\u00a0is where our team develops the cryo-EM workflow,\u00a0from sample preparation to vitrification and imaging.\u00a0Creating and running\u00a0our technology in a biosafety\u00a0environment\u00a0demonstrates\u00a0our\u00a0commitment to R&amp;D and, more importantly, to collaborating with scientists to\u00a0advance\u00a0cryo-EM\u00a0technology and\u00a0expand its use.<\/p>\n<p>Building on this expertise\u00a0and\u00a0given\u00a0the heightened interest\u00a0in bringing\u00a0cryo-EM into higher-level biosafety labs, we\u00a0are\u00a0announcing\u00a0our first dedicated solution\u00a0for\u00a0whole virus research: <a href=\"https:\/\/ter.li\/vi31c0\">the heat\u00a0decontamination solution<\/a> for\u00a0the\u00a0<a href=\"https:\/\/ter.li\/n3vnw3\">Thermo\u00a0Scientific\u00a0Krios\u00a0G4 Cryo-TEM<\/a> heats all components within the microscope enclosure to at least 60\u00b0C for a prescribed amount of time. This enables scientists to perform cryo-EM experiments on samples confined to higher-level biosafety facilities\u00a0(e.g., biosafety level 3)\u00a0that are susceptible to decontamination by heating to 60\u00b0C.<\/p>\n<p>Additionally, this solution contains components to prevent aerosol release and a second control station to control the microscope from the outside of the biosafety\u00a0lab.<\/p>\n<p>Finally, we can offer our\u00a0tailored\u00a0service solutions, leveraging our remote diagnostics,\u00a0repair capabilities and specially trained engineers for on-site service.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2112 size-full\" title=\"Quote from Kay Grunewald Center for Structural Systems Biology Hamburg\" src=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/04\/BSL-quote-1200x630-1.jpg\" alt=\"Quote from Kay Grunewald Center for Structural Systems Biology Hamburg: Many questions about the processes that occur in the course of viral infections and the nature of the underlying hijacking of cellular mechanisms remain unanswered. The current advancements in cryo-EM, and the prospect of bringing them into higher-containment labs, present an exciting platform to explore these questions.\" width=\"1200\" height=\"630\" \/><\/p>\n<h2 style=\"font-size: 100%\"><strong>What\u2019s\u00a0next for structural virology?\u00a0<\/strong><\/h2>\n<p>Our\u00a0commitment to making the world healthier, cleaner, and safer is evident\u2014and very much needed\u2014now, more than ever.<\/p>\n<p>I am deeply inspired by how the global research community has collectively risen to the challenge imposed by the pandemic.\u00a0Yet, the best part about this community is that they were preparing for this moment well in advance, having conducted\u00a0seminal research to understand the biology of SARS-CoV-2\u00a0decades\u00a0before its onset. Though\u00a0it\u2019s\u00a0difficult to say\u00a0during\u00a0a pandemic\u00a0that we must\u00a0prepare for\u00a0the next\u00a0one,\u00a0it is in fact how we must think.<\/p>\n<p>This\u00a0year,\u00a0we\u2019ll begin by offering our\u00a060\u00b0C\u00a0heat\u00a0decontamination\u00a0solution for the\u00a0Krios\u00a0Cryo-TEM in higher biosafety level facilities.<\/p>\n<p>Though we\u2019re proud to introduce it as our first, this\u00a0is only the start\u00a0of realizing a\u00a0vision and roadmap to bring\u00a0the\u00a0complete\u00a0in-situ <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/electron-microscopy\/life-sciences\/cryo-tomography.html\">cryo-electron tomography<\/a> (cryo-ET)\u00a0workflow\u00a0to biosafety level 3 facilities.<\/p>\n<p><a href=\"https:\/\/ter.li\/vi31c0\"><em>Learn more about our\u00a060\u00b0C heat decontamination\u00a0solution for the\u00a0Thermo\u00a0Scientific\u00a0Krios\u00a0G4\u00a0Cryo-TEM &gt;&gt;<\/em><\/a><\/p>\n<p><a href=\"https:\/\/ter.li\/e9w87x\"><em>Download our Ebook: Solving structural puzzles in virology with cryo-EM &gt;&gt;<\/em><\/a><\/p>\n<p>\/\/<\/p>\n<p><em>Steve\u00a0Reyntjens\u00a0is a\u00a0Senior Director of product marketing\u00a0at\u00a0Thermo\u00a0Fisher Scientific<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pathogenic\u00a0virus research: unanswered questions\u00a0 Cryo-electron microscopy (cryo-EM) has been used to study viral pathogens for more than 20 years, resolving the structures of viruses such as\u00a0Zika, Ebola, HIV, and\u00a0coronaviruses. During\u00a0the COVID-19 pandemic, cryo-EM played a pivotal role in accelerating vaccine development\u00a0and\u00a0antiviral drug discovery\u00a0for\u00a0this newly emerging pathogen. Despite the achievements of\u00a0virus research, many\u00a0viral pathogens\u00a0have yet\u00a0to be\u00a0studied,<\/p>\n","protected":false},"author":954,"featured_media":650,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[24,33],"tags":[15,16,117,90],"division":[],"class_list":{"0":"post-646","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cryo-electron-microscopy-cryo-em","8":"category-general","9":"tag-cryo-electron-microscopy","10":"tag-cryo-em","11":"tag-drug-discovery","12":"tag-virus","13":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- 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