{"id":731,"date":"2022-06-29T08:46:04","date_gmt":"2022-06-29T08:46:04","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/?p=731"},"modified":"2022-07-26T18:03:32","modified_gmt":"2022-07-26T18:03:32","slug":"smart-epu-single-particle-analysis-software","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/smart-epu-single-particle-analysis-software\/","title":{"rendered":"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection"},"content":{"rendered":"

The case for the automation in single particle analysis software<\/strong><\/h2>\n

More and more life scientists are adopting cryo-electron microscopy (cryo-EM) to advance their research and pharmaceutical projects. Yet, as the technique grows in popularity, so too does the strain on time and resourcing for expert users and their teams.<\/p>\n

Data collection for cryo-EM is still a very manual, complex process\u2014one that requires a high level of operator time and expertise. If we look at the adoption of cryo-EM in the pharmaceutical industry for instance, we see that the workflow\u2019s complexity has placed new pressures on drug discovery teams. The effort it takes to increase experience and capacity at pharmaceutical companies is likely limiting throughput and impacting their ability to keep up with the pace of medicinal chemistry and protein engineering.<\/p>\n

Across pharmaceuticals, biotech and academia, there is a clear need for the incorporation of automation, especially in single particle analysis<\/a> software for faster, more efficient and better-quality cryo-EM results accessible to expert and non-expert users.<\/p>\n

New Thermo Scientific Smart EPU Software <\/strong><\/h2>\n

Made possible through forward-looking insights, feedback and close collaboration with structural biologists around the world, we introduce our new Thermo Scientific Smart EPU Software<\/a>\u2014a single particle analysis software solution that offers more automation capabilities for cryo-EM data acquisition than ever before.<\/p>\n

This new software ecosystem is designed to reduce the number of manual steps it takes to set up and run a cryo-EM experiment, ensure data collected is of the highest quality possible, and provide on-the-fly, AI-assisted data analysis and decision-making.<\/p>\n

Smart EPU Software is now available across Thermo Fisher Scientific\u2019s cryo-TEM portfolio<\/a>, including on the Thermo Scientific Tundra, Glacios, and Krios Cryo-TEMs. For any of the three microscopes, Smart EPU can be customized to meet a lab\u2019s needs. Configuration options include the next-generation Thermo Scientific EPU 3 for semi-automated data acquisition, Thermo Scientific EPU Quality Monitor (EQM) for on-the-fly evaluation of image quality during acquisition, and EPU Multigrid for increasing efficiency by enabling unattended data collection.<\/p>\n

Some particularly exciting Smart EPU features enable users\u2014new and experienced\u2014to immediately identify problematic acquisitions and fix or skip them for better microscope efficiency and higher throughput capacity. These include the EPU 3 Traffic Light for easy visualization of the microscope\u2019s status and automated corrections to ensure optimal microscope state; a user-guided and automated microscope setup process, including AI-assisted target\/grid hole selection for ease-of-use and to reduce time-to-data; smart plugins for automatic adjustments based on real-time data without the need for user decisions based on processing results; automatic microscope behavior correction to remove the need for constant hands-on operation during data acquisition; and an open Application Programming Interface (API) platform, allowing the community to develop and add their own algorithms to the Smart EPU ecosystem.<\/p>\n

In combination, the Smart EPU single particle analysis software platform enables automated setup, faster data acquisition capabilities than existing packages, real-time quality assessments and AI-assisted decision-making.<\/p>\n

Streamlining cryo-EM software to advance structural biology efforts worldwide<\/strong><\/h2>\n

Just as life scientists are pushing the bounds of drug discovery<\/a>, we aim to do the same when it comes to technological innovation.<\/p>\n

By adding automation capabilities to our entire cryo-TEM portfolio, we\u2019re putting the most efficient and highest quality solutions in the hands of those making the world healthier, cleaner and safer.<\/p>\n

We hope that the addition of the Smart EPU single particle analysis software platform to our cryo-EM solutions suite will change the way life scientists collect data on cryo-electron microscopes, making acquisition easier than ever, reducing the time required to earn quality results and improving throughput, reliability and repeatability of cryo-EM pursuits.<\/p>\n

Learn more about Thermo Scientific Smart EPU Software<\/a> >><\/em><\/p>\n

\/\/<\/p>\n

Edward Pryor is Director of Product Development for Life Sciences at Thermo Fisher Scientific<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

The case for the automation in single particle analysis software More and more life scientists are adopting cryo-electron microscopy (cryo-EM) to advance their research and pharmaceutical projects. Yet, as the technique grows in popularity, so too does the strain on time and resourcing for expert users and their teams. Data collection for cryo-EM is still<\/p>\n","protected":false},"author":1651,"featured_media":733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[24,33,185],"tags":[216,15,16,76,186],"division":[],"class_list":{"0":"post-731","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cryo-electron-microscopy-cryo-em","8":"category-general","9":"category-software","10":"tag-automation","11":"tag-cryo-electron-microscopy","12":"tag-cryo-em","13":"tag-single-particle-analysis","14":"tag-software","15":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\nSingle Particle Analysis Software - Cryo EM - Life in Atomic Resolution<\/title>\n<meta name=\"description\" content=\"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/smart-epu-single-particle-analysis-software\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection\" \/>\n<meta property=\"og:description\" content=\"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/\" \/>\n<meta property=\"og:site_name\" content=\"Life in Atomic Resolution\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-29T08:46:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-26T18:03:32+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Edward Pryor\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Edward Pryor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/\"},\"author\":{\"name\":\"Edward Pryor\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/5ec6a18d432bb13598cf9967f67d2807\"},\"headline\":\"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection\",\"datePublished\":\"2022-06-29T08:46:04+00:00\",\"dateModified\":\"2022-07-26T18:03:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/\"},\"wordCount\":638,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2022\\\/06\\\/Smart-EPU-blog-1200-630.png\",\"keywords\":[\"automation\",\"cryo-electron microscopy\",\"cryo-EM\",\"single particle analysis\",\"software\"],\"articleSection\":[\"Cryo-Electron Microscopy (Cryo-EM)\",\"General\",\"Software\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/\",\"name\":\"Single Particle Analysis Software - Cryo EM - Life in Atomic Resolution\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2022\\\/06\\\/Smart-EPU-blog-1200-630.png\",\"datePublished\":\"2022-06-29T08:46:04+00:00\",\"dateModified\":\"2022-07-26T18:03:32+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/5ec6a18d432bb13598cf9967f67d2807\"},\"description\":\"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2022\\\/06\\\/Smart-EPU-blog-1200-630.png\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/wp-content\\\/uploads\\\/sites\\\/22\\\/2022\\\/06\\\/Smart-EPU-blog-1200-630.png\",\"width\":1200,\"height\":630,\"caption\":\"Single particle analysis software categorizing a cryo-EM grid\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/smart-epu-single-particle-analysis-software\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/\",\"name\":\"Life in Atomic Resolution\",\"description\":\"Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/atomic-resolution\\\/#\\\/schema\\\/person\\\/5ec6a18d432bb13598cf9967f67d2807\",\"name\":\"Edward Pryor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g\",\"caption\":\"Edward Pryor\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/epryor\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Single Particle Analysis Software - Cryo EM - Life in Atomic Resolution","description":"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/smart-epu-single-particle-analysis-software\/","og_locale":"en_US","og_type":"article","og_title":"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection","og_description":"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.","og_url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/","og_site_name":"Life in Atomic Resolution","article_publisher":"https:\/\/www.facebook.com\/thermofisher","article_published_time":"2022-06-29T08:46:04+00:00","article_modified_time":"2022-07-26T18:03:32+00:00","og_image":[{"width":1200,"height":630,"url":"http:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","type":"image\/png"}],"author":"Edward Pryor","twitter_card":"summary_large_image","twitter_creator":"@thermofisher","twitter_site":"@thermofisher","twitter_misc":{"Written by":"Edward Pryor","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#article","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/"},"author":{"name":"Edward Pryor","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/5ec6a18d432bb13598cf9967f67d2807"},"headline":"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection","datePublished":"2022-06-29T08:46:04+00:00","dateModified":"2022-07-26T18:03:32+00:00","mainEntityOfPage":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/"},"wordCount":638,"commentCount":0,"image":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","keywords":["automation","cryo-electron microscopy","cryo-EM","single particle analysis","software"],"articleSection":["Cryo-Electron Microscopy (Cryo-EM)","General","Software"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/","url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/","name":"Single Particle Analysis Software - Cryo EM - Life in Atomic Resolution","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#website"},"primaryImageOfPage":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#primaryimage"},"image":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","datePublished":"2022-06-29T08:46:04+00:00","dateModified":"2022-07-26T18:03:32+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/5ec6a18d432bb13598cf9967f67d2807"},"description":"Thermo Scientific Smart EPU Software is single particle analysis software that enables intelligent and automated cryo-EM data collection.","breadcrumb":{"@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","contentUrl":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","width":1200,"height":630,"caption":"Single particle analysis software categorizing a cryo-EM grid"},{"@type":"BreadcrumbList","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/smart-epu-single-particle-analysis-software\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/"},{"@type":"ListItem","position":2,"name":"Smart EPU: New Single Particle Analysis Software Enables Intelligent and Automated Cryo-EM Data Collection"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#website","url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/","name":"Life in Atomic Resolution","description":"Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/#\/schema\/person\/5ec6a18d432bb13598cf9967f67d2807","name":"Edward Pryor","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/9c05f9973d2b3f01d0bf51a5c0c743151f7b249824b094fc1ceb508db54f82d2?s=96&d=mm&r=g","caption":"Edward Pryor"},"url":"https:\/\/admin.acceleratingscience.com\/author\/epryor\/"}]}},"taxonomy_info":{"category":[{"value":24,"label":"Cryo-Electron Microscopy (Cryo-EM)"},{"value":33,"label":"General"},{"value":185,"label":"Software"}],"post_tag":[{"value":216,"label":"automation"},{"value":15,"label":"cryo-electron microscopy"},{"value":16,"label":"cryo-EM"},{"value":76,"label":"single particle analysis"},{"value":186,"label":"software"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630-1024x538.png",760,399,true],"author_info":{"display_name":"Edward Pryor","author_link":"https:\/\/admin.acceleratingscience.com\/author\/epryor\/"},"comment_info":0,"category_info":[{"term_id":24,"name":"Cryo-Electron Microscopy (Cryo-EM)","slug":"cryo-electron-microscopy-cryo-em","term_group":0,"term_taxonomy_id":24,"taxonomy":"category","description":"","parent":0,"count":79,"filter":"raw","meta":[],"cat_ID":24,"category_count":79,"category_description":"","cat_name":"Cryo-Electron Microscopy (Cryo-EM)","category_nicename":"cryo-electron-microscopy-cryo-em","category_parent":0},{"term_id":33,"name":"General","slug":"general","term_group":0,"term_taxonomy_id":33,"taxonomy":"category","description":"","parent":0,"count":59,"filter":"raw","meta":[],"cat_ID":33,"category_count":59,"category_description":"","cat_name":"General","category_nicename":"general","category_parent":0},{"term_id":185,"name":"Software","slug":"software","term_group":0,"term_taxonomy_id":185,"taxonomy":"category","description":"","parent":0,"count":16,"filter":"raw","meta":[],"cat_ID":185,"category_count":16,"category_description":"","cat_name":"Software","category_nicename":"software","category_parent":0}],"tag_info":[{"term_id":216,"name":"automation","slug":"automation","term_group":0,"term_taxonomy_id":216,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":15,"name":"cryo-electron microscopy","slug":"cryo-electron-microscopy","term_group":0,"term_taxonomy_id":15,"taxonomy":"post_tag","description":"","parent":0,"count":62,"filter":"raw","meta":[]},{"term_id":16,"name":"cryo-EM","slug":"cryo-em","term_group":0,"term_taxonomy_id":16,"taxonomy":"post_tag","description":"","parent":0,"count":63,"filter":"raw","meta":[]},{"term_id":76,"name":"single particle analysis","slug":"single-particle-analysis","term_group":0,"term_taxonomy_id":76,"taxonomy":"post_tag","description":"","parent":0,"count":5,"filter":"raw","meta":[]},{"term_id":186,"name":"software","slug":"software","term_group":0,"term_taxonomy_id":186,"taxonomy":"post_tag","description":"","parent":0,"count":4,"filter":"raw","meta":[]}],"jetpack-related-posts":[{"id":1854,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/advances-in-100-kv-high-resolution-cryo-em-single-particle-analysis\/","url_meta":{"origin":731,"position":0},"title":"Advances in high-resolution cryo-EM at 100 kV","author":"Swarnim Rawat","date":"February 5, 2026","format":false,"excerpt":"100 kV cryo-TEM enables high-resolution single particle analysis Within the past decade, cryo-electron microscopy (cryo-EM) techniques have revolutionized structural biology by enabling the visualization of challenging molecular and sub-cellular structures in their near-native states at high resolution. These valuable observations have, until recently, been relegated to advanced 300 kV instruments\u2026","rel":"","context":"In "Cryo-Electron Microscopy (Cryo-EM)"","block_context":{"text":"Cryo-Electron Microscopy (Cryo-EM)","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/"},"img":{"alt_text":"Advances in high-resolution cryo-EM at 100 kV","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1935,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/fragment-based-drug-discovery-of-drug-targets-membrane-proteins-with-cryo-em\/","url_meta":{"origin":731,"position":1},"title":"Fragment based drug discovery meets challenging drug targets with high-throughput cryo-EM\u00a0","author":"Swarnim Rawat","date":"December 12, 2025","format":false,"excerpt":"Benefits of FBDD in the search for novel therapeutics\u00a0 Fragment-based drug discovery (FBDD) is a method that screens a large quantity of protein fragments for their potential as small molecule therapeutics. This approach was previously hampered by the slow throughput of crystallization for the characterization of potential leads. The increasing\u2026","rel":"","context":"In "Cryo EM Drug Discovery"","block_context":{"text":"Cryo EM Drug Discovery","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-drug-discovery\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2117,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/advances-in-cryo-electron-tomography-expand-the-capabilities-of-quantitative-cell-biology\/","url_meta":{"origin":731,"position":2},"title":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology","author":"Vinay S","date":"September 29, 2026","format":false,"excerpt":"Key takeaways Cryo-electron tomography has largely been seen as a qualitative method because cryo-ET data segmentation has been a highly intensive, manual process. Recent advances in deep-learning-based segmentation have expanded the capabilities of cryo-electron tomography, supporting quantitative analysis of cellular structures. A recent webinar by Professor Danielle Grotjahn highlights how\u2026","rel":"","context":"In "Cryo EM Techniques"","block_context":{"text":"Cryo EM Techniques","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-techniques\/"},"img":{"alt_text":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2172,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/what-is-subtomogram-averaging\/","url_meta":{"origin":731,"position":3},"title":"What is Subtomogram Averaging?","author":"Swarnim Rawat","date":"October 19, 2026","format":false,"excerpt":"Turning crowded cryo-ET data into structural insight with subtomogram averaging Cryo-electron tomography (cryo-ET) is capable of capturing detailed, three-dimensional views of vitrified biological samples, supporting a broad range of life sciences research. Subtomogram averaging helps refine that crowded data for clearer structural insight by finding repeated particles, extracting them as\u2026","rel":"","context":"In "Cancer Research"","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/cancer-research\/"},"img":{"alt_text":"Social Cryo EM","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/social.png?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":2143,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/microscopy-image-analysis-with-amira-software-ai-in-cell-biology\/","url_meta":{"origin":731,"position":4},"title":"Four ways AI is making microscopy image analysis easier for cell biologists","author":"Alejandra Sanchez-Erostegui","date":"October 14, 2026","format":false,"excerpt":"Key takeaways Modern microscopes are capable of generating large volumes of high-resolution data, which is highly valuable for cell biology research, but also makes it increasingly more laborious and difficult to extract meaningful scientific information from the whole dataset.\u00a0 Artificial intelligence is well positioned to support this work by streamlining\u2026","rel":"","context":"In "Amira Software"","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"Four ways AI is making microscopy image analysis easier for cell biologists.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/10\/fault-localization-root-cause-ai-packaging-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2016,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/how-artificial-intelligence-ai-improves-image-analysis-workflows-in-life-sciences\/","url_meta":{"origin":731,"position":5},"title":"How artificial intelligence (AI) improves image analysis workflows in life sciences","author":"Vinay S","date":"June 2, 2026","format":false,"excerpt":"Image acquisition is not the end of the story\u2014it is the starting point. Once images are captured, researchers typically move into preprocessing to improve quality, then they perform visualization, segmentation, and quantitative analysis to extract meaningful measurements. The goal is simple: turn images into understanding. In practice, however, image analysis\u2026","rel":"","context":"In "Amira Software"","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"How artificial intelligence (AI) improves image analysis workflows in life sciences","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/06\/Smart-EPU-blog-1200-630.png","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/users\/1651"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/comments?post=731"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/731\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media\/733"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media?parent=731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/categories?post=731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/tags?post=731"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/division?post=731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}