{"id":938,"date":"2022-12-19T07:39:37","date_gmt":"2022-12-19T07:39:37","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/?p=938"},"modified":"2023-11-27T18:55:33","modified_gmt":"2023-11-27T18:55:33","slug":"cryo-tem-transmission-electron-microscopy-simplified","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/cryo-tem-transmission-electron-microscopy-simplified\/","title":{"rendered":"Thermo Fisher Scientific Hits the Road to Showcase Simplified Cryo-TEM"},"content":{"rendered":"

During the fall semester, we visited colleges and institutions around the United States to showcase the Thermo Scientific Tundra Cryo-Transmission Electron Microscope<\/a> (Cryo-TEM). Designed for expert microscopists and newcomers alike, the Tundra Cryo-TEM makes it easy to bring structural analysis in house<\/a>, offering faster sample loading and unloading and a simpler workflow for cryo-EM data collection.<\/p>\n

\"Thermo<\/p>\n

Through a remote live demo via the Thermo Fisher Scientific NanoPort, attendees got a first-hand look at how easy it can be to obtain structures at biologically relevant resolutions and prepare samples for analysis on more powerful transmission electron microscopy systems like the Thermo Scientific Krios<\/a> and Glacios<\/a> Cryo-TEMs.<\/p>\n

Watch our on-demand webinar for a closer look at the Tundra Cryo-TEM<\/a> >><\/em><\/strong><\/p>\n

Streamlining structural biology research with cryo-TEM<\/strong><\/h2>\n

At each stop we shared how the Tundra Cryo-TEM can help optimize biological samples\u2014a difficult task that can lead to a variety of problems and that is often a bottleneck in the cryo-electron microscopy workflow. For example, when a grid is glow discharged, very few oligomeric protein complex particles can be observed. But by altering the time and the strength of the plasma treatment, users can dramatically alter the particle distribution\u2014a difference that\u2019s easy to see with TEM imaging.<\/p>\n

\"Differences

Differences in particle distribution resulting from different plasma treatments. Images created on a Tundra Cryo-TEM. Drulyte et. al. 2018, Acta Crystallographica Section D: Structural Biology<\/p><\/div>\n

Similarly, the Tundra Cryo-TEM has been used to help optimize the expression and purification systems for AAV, which are used in gene therapy to package and deliver the intended genes to patients. A micrograph and 3D classes created with the instrument clearly show full and empty populations, helping researchers understand how to increase the percentage of full particles and ultimately create more effective treatments.<\/p>\n

\"Tundra

Micrograph and 3D classes of AAV created with the Tundra Cryo-TEM.<\/p><\/div>\n

Simplifying the workflow with automated imaging <\/strong><\/h2>\n
\"Thermo

Thermo Scientific Tundra Workshop at Emory University<\/p><\/div>\n

These demonstrations highlighted not only the results that the Tundra Cryo-TEM can deliver but also how it simplifies the TEM imaging workflow. The system features a new, semi-automated loader that makes it possible to load and unload samples in less than 10 minutes, allowing for an iterative way of working. It uses the same Autogrids that are compatible with the Krios and Glacios Cryo-TEMs, making it easier to switch between the instruments. And it delivers instant feedback on biochemistry adjustments\u2014faster than other technologies.<\/p>\n

The AI-guided automation makes operation easy for all users\u2014years of experience are no longer needed to perform transmission electron microscopy. Guided alignment helps researchers load and run the instrument, and the user-friendly interface automates data collection. The intuitive traffic lights panel indicates and helps to correct any issues. AI decision making adjusts the system automatically, finding and focusing on areas of the grid that will produce usable data. And the system analyzes intermediate results on the fly to provide instant user feedback and steer data collection.<\/p>\n

When surveyed about their previous experience in cryo-EM, almost half of attendee respondents shared that they\u2019re just getting started with the technique, and 86% said they\u2019re most compelled by the Tundra Cryo-TEM’s overall ease-of-use.<\/p>\n

With a simplified workflow, the Thermo Scientific Tundra Cryo-TEM can help scientists bring structural biology into their labs to help answer some of their most challenging research questions quickly and at an affordable price point.<\/p>\n

Watch our Getting Started in Cryo-EM webinar to learn more about the Tundra Cryo-TEM and see how it can fit in your lab<\/a> >><\/strong><\/p>\n

\"Subscribe<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

During the fall semester, we visited colleges and institutions around the United States to showcase the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM). Designed for expert microscopists and newcomers alike, the Tundra Cryo-TEM makes it easy to bring structural analysis in house, offering faster sample loading and unloading and a simpler workflow for cryo-EM data<\/p>\n","protected":false},"author":1700,"featured_media":939,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[24,33],"tags":[15,16,70,119,59],"division":[],"class_list":{"0":"post-938","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cryo-electron-microscopy-cryo-em","8":"category-general","9":"tag-cryo-electron-microscopy","10":"tag-cryo-em","11":"tag-cryo-em-single-particle-analysis","12":"tag-tem","13":"tag-transmission-electron-microscope","14":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\nCryo-TEM 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These valuable observations have, until recently, been relegated to advanced 300 kV instruments\u2026","rel":"","context":"In "Cryo-Electron Microscopy (Cryo-EM)"","block_context":{"text":"Cryo-Electron Microscopy (Cryo-EM)","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/"},"img":{"alt_text":"Advances in high-resolution cryo-EM at 100 kV","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/08\/Blog-Tundra-Preprint-1858725-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2117,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/advances-in-cryo-electron-tomography-expand-the-capabilities-of-quantitative-cell-biology\/","url_meta":{"origin":938,"position":1},"title":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology","author":"Vinay S","date":"September 29, 2026","format":false,"excerpt":"Key takeaways Cryo-electron tomography has largely been seen as a qualitative method because cryo-ET data segmentation has been a highly intensive, manual process. Recent advances in deep-learning-based segmentation have expanded the capabilities of cryo-electron tomography, supporting quantitative analysis of cellular structures. A recent webinar by Professor Danielle Grotjahn highlights how\u2026","rel":"","context":"In "Cryo EM Techniques"","block_context":{"text":"Cryo EM Techniques","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-techniques\/"},"img":{"alt_text":"Advances in cryo-electron tomography expand the capabilities of quantitative cell biology.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/09\/blog-cryo-em-series-header-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":1935,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/fragment-based-drug-discovery-of-drug-targets-membrane-proteins-with-cryo-em\/","url_meta":{"origin":938,"position":2},"title":"Fragment based drug discovery meets challenging drug targets with high-throughput cryo-EM\u00a0","author":"Swarnim Rawat","date":"December 12, 2025","format":false,"excerpt":"Benefits of FBDD in the search for novel therapeutics\u00a0 Fragment-based drug discovery (FBDD) is a method that screens a large quantity of protein fragments for their potential as small molecule therapeutics. This approach was previously hampered by the slow throughput of crystallization for the characterization of potential leads. The increasing\u2026","rel":"","context":"In "Cryo EM Drug Discovery"","block_context":{"text":"Cryo EM Drug Discovery","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/cryo-em-drug-discovery\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2025\/12\/blog-8-banner-1920x450-1.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2016,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/how-artificial-intelligence-ai-improves-image-analysis-workflows-in-life-sciences\/","url_meta":{"origin":938,"position":3},"title":"How artificial intelligence (AI) improves image analysis workflows in life sciences","author":"Vinay S","date":"June 2, 2026","format":false,"excerpt":"Image acquisition is not the end of the story\u2014it is the starting point. Once images are captured, researchers typically move into preprocessing to improve quality, then they perform visualization, segmentation, and quantitative analysis to extract meaningful measurements. The goal is simple: turn images into understanding. In practice, however, image analysis\u2026","rel":"","context":"In "Amira Software"","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"How artificial intelligence (AI) improves image analysis workflows in life sciences","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/06\/amira-ai-tools-blog-header-1920x450-1.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2071,"url":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/facilitating-soft-tissue-analysis-unraveling-complex-microct-imaging-data-with-amira-software\/","url_meta":{"origin":938,"position":4},"title":"Facilitating Soft Tissue Analysis \u2013 Unraveling Complex MicroCT Imaging Data with Amira Software","author":"Vinay S","date":"August 27, 2026","format":false,"excerpt":"Key takeaways Micro-computed X-ray tomography (microCT) can be used for high-resolution, 3D visualization of a range of biological samples, including soft tissues, but transforming this data into scientific insights requires the processing of increasingly large, complex datasets. 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Historically, these samples were imaged as thin\u2026","rel":"","context":"In "Amira Software"","block_context":{"text":"Amira Software","link":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/cryo-electron-microscopy-cryo-em\/amira-software\/"},"img":{"alt_text":"3D Tissue Histology with Light-Sheet Microscopy Enables Nondestructive Analysis of Microglia","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2026\/01\/neuroscience-blog-header-1920x450-1.png?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/atomic-resolution\/wp-content\/uploads\/sites\/22\/2022\/12\/Tundra-Roadshow-recap-1200x630-2.png","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/users\/1700"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/comments?post=938"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/posts\/938\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media\/939"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/media?parent=938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/categories?post=938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/tags?post=938"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/atomic-resolution\/wp-json\/wp\/v2\/division?post=938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}