Raman spectroscopy is a highly regarded method that benefits analytical, laboratory and process monitoring applications. Real-time process understanding is just one benefit of using Raman, and it allows users to make timely corrections and increase process efficiency, along with many other advantages. This blog post will look at why Raman is an ideal component for process monitoring.
Raman spectroscopy is a non-invasive analytical technique to obtain information about a molecule’s chemical and structural composition. This method works by directing a laser light source at a sample through which the light is scattered. The light that is scattered at different wavelengths makes up a Raman spectrum that can be used to verify the chemical identity of a sample and even quantify the concentration of a sample.
How Does Raman Benefit Process Monitoring?
Process monitoring is used for several reasons. When manufacturers are carrying out operations, monitoring is necessary to ensure the processes are accurate, safe, reliable and result in the desired product. Process monitoring tools are also essential in identifying errors, failures, or potential risks before they become quality issues.
Raman spectroscopy has been crucial to many applications in the pharmaceutical industry for many years because of its main advantages. Using Raman-based process analytical technologies (PAT) for process monitoring, especially in-line, offers key benefits that help improve processes and ensure their safety. Additionally, scientists can be notified immediately of any damages or errors, allowing them to make corrections in real time.
Not only is Raman extremely sensitive to the composition and structure of a molecule, but it also enables the accurate characterization of samples. Raman can be used to analyze samples in optically transparent containers or even in water, all without the need for preparation or contact.
Some of the other benefits include the following:
- Easy to set up: Saving time and money on additional installation costs
- Non-destructive: Samples need not be damaged, and the risk of contamination is reduced
- No sample preparation: Meaningful time can be spent on other parts of the overall development or production process
- Non-interruptive: Processes need not be stopped nor paused to perform analysis
- Improved process understanding and efficiency
- Suitable for harsh environments, including high temperatures
For effective and accurate process monitoring, choosing a suitable analyzer is crucial. The right analyzer should enable easy and non-destructive real-time measurements that are precise and prompt. A process analyzer should remove the need for lengthy sample preparation methods, reduce contamination risks and ultimately help to improve the speed and efficiency of the process.
Read about additional technologies on our website for Improving Pharmaceutical and Biotech Manufacturing Processes
Author: Dean Stuart
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