{"id":10088,"date":"2017-01-25T05:02:00","date_gmt":"2017-01-25T05:02:00","guid":{"rendered":"http:\/\/admin.acceleratingscience.com\/behindthebench\/?p=10088"},"modified":"2018-05-24T03:22:39","modified_gmt":"2018-05-24T03:22:39","slug":"novel-methods-for-glycan-analysis-seq-it-out-18","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/novel-methods-for-glycan-analysis-seq-it-out-18\/","title":{"rendered":"Novel Methods for Glycan Analysis &#8211; Seq It Out #18"},"content":{"rendered":"<p>Did you know that analyzing glycan profiles is crucial for any scientist working with glycoproteins, but that the process can get really frustrating when analyzing large numbers of samples? While some good methods for glycan analysis have been used routinely over the years, thanks to new methods, we have better solutions available now to analyze glycans.<\/p>\n<p><iframe loading=\"lazy\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/MwjlTF0Lxvw?start=2&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Liquid chromatography is most commonly used to separate and quantify glycans. It provides high resolution of glycan separation and great data. However, to obtain great data for 96 samples, the overall process from sample prep to analysis takes about 2-3 days.<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/sanger-sequencing.html?cid=social_btb_abseq\" target=\"_blank\">Capillary electrophoresis<\/a>, also known as CE, is another technique that can give high data quality and resolution; similar to liquid chromatography. But currently used CE methods are not robust and the instruments tend to have frail capillaries. Current CE methods can take 2-3 days to prepare, process and analyze 96 samples and therefore don\u2019t solve the low throughput problem presented by liquid chromatography.<\/p>\n<p>Microchip based systems have solved the low throughput problem, but only at the expense of data quality and resolution. Because of a short separation window, microchip based methods cannot provide high resolution of separation. This means that you have to choose multiple platforms in order to get both high throughput AND high resolution.<\/p>\n<p>Think you need to choose between high throughput and high resolution? Well let\u2019s talk about a new solution in the market that might offer you the best of both worlds.<\/p>\n<p>Thermo Fisher\u2019s Applied Biosystems recently introduced <a href=\"http:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/bioproduction\/contaminant-and-impurity-testing\/glycanAssure-Glycan-analysis.html?cid=social_btb_abseq\">GlycanAssure<\/a>, an end-to-end solution for glycan analysis and quantitation. With this CE based GlycanAssure system, you can prepare, process and analyze 96 samples in one workday. Moreover, it is the only system that gives you both, high throughput and high resolution. Its magnetic bead-based sample prep method uses highly sensitive dyes that enable use of very small amounts of sample.<\/p>\n<p><a href=\"http:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/sanger-sequencing\/sanger-sequencing-technology-accessories\/applied-biosystems-sanger-sequencing-3500-series-genetic-analyzers\/3500-series-genetic-analyzer.html?cid=social_btb_abseq\">The 3500 Genetic Analyzer<\/a>, which is the CE instrument in the GlycanAssure system, has been used for years in forensic and clinical research labs for genetic analysis. This speaks volumes about the instrument\u2019s robustness. Contrary to running one sample at a time sequentially, its capillary array consists of 8 and 24 capillaries enabling all samples to run parallel to each other AT THE SAME TIME. These capillaries enable consistent results over long periods of time and across multiple capillaries. So run-to-run, day-to-day, and capillary-to-capillary, the system is designed to produce reliable data. The ability to analyze glycans in parallel offers a system that combines very high throughput and high data quality with FAST and accurate results.<\/p>\n<p>GlycanAssure has simple and intuitive software that provides data trends and the ability to analyze data for 96 samples within one hour. The data acquisition dashboard provides easy access to instrument status and setup. Using the step-by-step workflow, you can create your favorite experiments and directly report or export your data<\/p>\n<p>GlycanAssure minimizes the need to use several platforms to address high throughput and high data quality by giving you the option of doing both with ONE system. If you want to learn more about GlycanAssure, please visit our website at <a href=\"http:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/bioproduction\/contaminant-and-impurity-testing\/glycanAssure-Glycan-analysis.html?cid=social_btb_abseq\">thermofisher.com\/glycanassure<\/a>.<\/p>\n<p>And remember, when in doubt, just Seq It Out<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Did you know that analyzing glycan profiles is crucial for any scientist working with glycoproteins, but that the process can get really frustrating when analyzing large numbers of samples? While some good methods for glycan analysis have been used routinely over the years, thanks to new methods, we have better solutions available now to analyze<\/p>\n","protected":false},"author":114,"featured_media":10089,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[108,101],"tags":[17,36,228,176,74],"division":[],"class_list":{"0":"post-10088","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-lab-tips-and-tricks","8":"category-product-news","9":"tag-applied-biosystems","10":"tag-capillary-electrophoresis","11":"tag-glycan-analysis","12":"tag-seqitout","13":"tag-sequencing","14":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Novel Methods for Glycan Analysis - Seq It Out #18 - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/novel-methods-for-glycan-analysis-seq-it-out-18\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Methods for Glycan Analysis - Seq It Out #18\" \/>\n<meta property=\"og:description\" content=\"Did you know that analyzing glycan profiles is crucial for any scientist working with glycoproteins, but that the process can get really frustrating when analyzing large numbers of samples? 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Today\u2019s labs are not only looking for accuracy\u2014they need speed, flexibility, and reliable\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"DNA sequencing sample tube with DNA helix and sequencing chromatogram representing Sanger sequencing workflow.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19658,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/is-raman-spectroscopy-a-better-verification-method-in-pharmaceutical-manufacturing\/","url_meta":{"origin":10088,"position":1},"title":"Is Raman Spectroscopy a Better Verification Method in Pharmaceutical Manufacturing?","author":"Marlene Gasdia-Cochrane","date":"May 5, 2026","format":false,"excerpt":"Article Summary Verification testing is a critical step in pharmaceutical manufacturing, helping to ensure that every product released meets strict safety, quality, and regulatory standards. Verification helps ensure that products contain the correct active ingredients, meet concentration specifications, are free from contamination, and maintain structural and chemical integrity. This process\u2026","rel":"","context":"In &quot;Pharma &amp; Biotech Manufacturing&quot;","block_context":{"text":"Pharma &amp; Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"Yellow pill and red check mark sitting on brown wood surface in front of abstract defocused background. Horizontal composition with selective focus and copy space. Front view. 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As more of the research process becomes automated and data-driven, an important question emerges: What should researchers consider about how data is generated before downstream analysis begins? 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Real-time process monitoring provides continuous insight into critical variables such as protein concentration and buffer composition, helping teams make faster decisions, reduce process variability, and improve control during therapeutic protein production. The challenges of downstream processing\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. 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