{"id":11591,"date":"2018-09-12T16:40:23","date_gmt":"2018-09-12T16:40:23","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/?p=11591"},"modified":"2018-10-18T23:49:14","modified_gmt":"2018-10-18T23:49:14","slug":"targeted-gbs-flexibility-accelerates-genomic-breeding-programs","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/","title":{"rendered":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs"},"content":{"rendered":"<p>Utilizing genomic information to increase profitability and improve production in livestock has become an essential component of modern breeding strategies. With rapidly changing genomic technology resulting in an accelerated rate of discovery of new genetic markers, it is important that genetic laboratories adapt quickly and provide cost-effective solutions for producers to take advantage of this information. The targeted genotyping-by-sequencing (GBS) approach using the AgriSeq workflow streamlines the process of developing custom genetic marker panels and provides the flexibility to quickly modify or combine existing genetic marker panels.<\/p>\n<p>Beef and dairy cattle breeding programs have benefitted greatly from advances in genomic technologies. There has been an accelerated rate of uptake in the United States dairy industry since 2010, with data showing increased value and net merit. Genomic testing has increased lifetime profitability through selecting traits of economic importance in the industry. Aaron Larsen, Chief Science Officer with <a href=\"http:\/\/unitedbioresearchinc.com\/\" target=\"_blank\" rel=\"noopener\">United Bio Research, Inc.<\/a>\u00a0explained recently why he has been using Applied Biosystems AgriSeq targeted <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/agricultural-biotechnology\/agrigenomics\/agriseq-targeted-genotyping-sequencing.html\" target=\"_blank\" rel=\"noopener\">genotyping-by-sequencing (GBS) workflows<\/a>\u00a0in conjunction with the Thermo Fisher Scientific <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-run-sequence\/ion-s5-ngs-targeted-sequencing.html\" target=\"_blank\" rel=\"noopener\">GeneStudio system<\/a> to develop customized solutions for cattle breeders.<\/p>\n<p>During an <a href=\"https:\/\/www.youtube.com\/watch?v=6mpXJ3ll_GE\" target=\"_blank\" rel=\"noopener\">interview<\/a>, Larsen cites two factors \u2014 scalability and cost effectiveness \u2014 in the decision to focus on targeted GBS for supporting United Bio Research\u2019s beef and dairy customers. The company develops customized genotyping panels, servicing operations with both high- and low-throughput. Requirements. With the AgriSeq workflows in conjunction with Ion S5 system technology, Larsen can leverage flexibility to keep costs low and results fast for all customer expectations.<\/p>\n<p><iframe loading=\"lazy\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/6mpXJ3ll_GE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>\u201cTargeted GBS flexibility,\u201d he explains, \u201cmeans we can customize specifically by customer in a lot better way.\u201d<\/p>\n<p>The United Bio Research solutions for dairy and beef genomic breeding programs include panels for disease mutations, economic traits, parentage assessment and gender identification. The panels developed so far include more than 65 markers for genetic disease and more than 70 variants that associate with traits of economic importance. The parentage panel incorporates the 200 advised SNPs (single nuclear polymorphisms) advised by ISAG (International Society for Animal Genetics). As discussed previously <em>[insert link to the first beef and cattle BTB post here] <\/em>, breeders should concentrate only on markers important to own operation. For this reason, Larsen and his team create sequencing plates customized for each breeder.<\/p>\n<p>Traditionally, sequencing costs decrease with high throughput for large numbers of samples. Larsen explains that the AgriSeq targeted GBS technology makes this possible even for customers with low throughput needs. This is due to the built-in flexibility of the system. Not only is it easy to add to and design new panels, but many panels can be sequenced in the same run. Hence, a low throughput panel is run alongside high throughput to keep costs low and benefit all customers.<\/p>\n<p>As well as being able to design according to client specific needs, Larsen also notes that the AgriSeq workflow lets the research team react swiftly to new molecular discoveries. With each new trait, variant or mutation, Larsen and his team have capability to quickly add the information into customer sequencing panels.<\/p>\n<p>The ease-of-use also benefits panel development. In developing gender identification panels, Larsen found that the targeted GBS approach could not only show Y-chromosome variants to detect Freemartinism, but also mutations beyond the standard read lengths. In collaboration with Thermo Fisher Scientific, the United Bio Research team designed primers to amplify polled mutations such as the Celtic Polled and Friesian Polled markers. They then worked with Thermo Fisher Scientific bioinformatics professionals to validate approaches to measuring copy number and so detect heterozygosity for carrier status.<\/p>\n<p>By implementing Applid Biosystems AgriSeq technology and workflows, Larsen and his United Bio Research team are able to take immediate advantage of molecular discovery to benefit customers in the beef and dairy cattle industry.<\/p>\n<p>Learn more about Aaron Larsen\u2019s work with AgriSeq workflows in this World Congress on Genetics Applied to <a href=\"https:\/\/www.youtube.com\/watch?v=5IL1VIfDbN0\" target=\"_blank\" rel=\"noopener\">Livestock Production WCGALP workshop video<\/a><\/p>\n<p>See what Thermo Fisher Scientific delivers for <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/agricultural-biotechnology\/agrigenomics.html\" target=\"_blank\" rel=\"noopener\">Agrigenomics<\/a><\/p>\n<p>To see how our solutions can improve your breeding program, receive a <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/global\/forms\/agbio-contact-form.html\" target=\"_blank\" rel=\"noopener\">free consulation<\/a> with a genotyping specialist<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right\"><em>For Research Use Only. Not for use in diagnostic procedures.<\/em><\/p>\n<p><!-- BEGIN KAPOST ANALYTICS CODE --><\/p>\n<p><!-- var _kaq = _kaq || []; _kaq.push([2, \"5b355c5a714bea00c700008a\", \"5674227b963491538f00011d\"]); (function(){ var ka = document.createElement(\"script\"); ka.async=true; ka.id=\"ka_tracker\"; ka.src = (document.location.protocol == \"https:\" ? \"https\" : \"http\") + \":\/\/analytics.kapost.com\/ka.js\"; var s = document.getElementsByTagName(\"script\")[0]; s.parentNode.insertBefore(ka, s); })(); \/\/--><\/p>\n<p><!-- END KAPOST ANALYTICS CODE --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Utilizing genomic information to increase profitability and improve production in livestock has become an essential component of modern breeding strategies. With rapidly changing genomic technology resulting in an accelerated rate of discovery of new genetic markers, it is important that genetic laboratories adapt quickly and provide cost-effective solutions for producers to take advantage of this<\/p>\n","protected":false},"author":120,"featured_media":11594,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[83],"tags":[74],"division":[],"class_list":{"0":"post-11591","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-animal-health-and-agrigenomics","8":"tag-sequencing","9":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Targeted GBS Flexibility Accelerates Genomic Breeding Programs - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeted GBS Flexibility Accelerates Genomic Breeding Programs\" \/>\n<meta property=\"og:description\" content=\"Utilizing genomic information to increase profitability and improve production in livestock has become an essential component of modern breeding strategies. With rapidly changing genomic technology resulting in an accelerated rate of discovery of new genetic markers, it is important that genetic laboratories adapt quickly and provide cost-effective solutions for producers to take advantage of this\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/\" \/>\n<meta property=\"og:site_name\" content=\"Behind the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-12T16:40:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-18T23:49:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1065\" \/>\n\t<meta property=\"og:image:height\" content=\"596\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Behind The Bench Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Behind The Bench Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/\"},\"author\":{\"name\":\"Behind The Bench Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/9bbb2d67616274d3d4a21a584f7f4a0c\"},\"headline\":\"Targeted GBS Flexibility Accelerates Genomic Breeding Programs\",\"datePublished\":\"2018-09-12T16:40:23+00:00\",\"dateModified\":\"2018-10-18T23:49:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/\"},\"wordCount\":693,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2018\\\/09\\\/Aaron-Larsen.png\",\"keywords\":[\"sequencing\"],\"articleSection\":[\"Animal Health and AgriGenomics\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/\",\"name\":\"Targeted GBS Flexibility Accelerates Genomic Breeding Programs - Behind the Bench\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2018\\\/09\\\/Aaron-Larsen.png\",\"datePublished\":\"2018-09-12T16:40:23+00:00\",\"dateModified\":\"2018-10-18T23:49:14+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/9bbb2d67616274d3d4a21a584f7f4a0c\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2018\\\/09\\\/Aaron-Larsen.png\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2018\\\/09\\\/Aaron-Larsen.png\",\"width\":1065,\"height\":596},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Targeted GBS Flexibility Accelerates Genomic Breeding Programs\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/\",\"name\":\"Behind the Bench\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/9bbb2d67616274d3d4a21a584f7f4a0c\",\"name\":\"Behind The Bench Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g\",\"caption\":\"Behind The Bench Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/behind-the-bench-staff\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs - Behind the Bench","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/","og_locale":"en_US","og_type":"article","og_title":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs","og_description":"Utilizing genomic information to increase profitability and improve production in livestock has become an essential component of modern breeding strategies. With rapidly changing genomic technology resulting in an accelerated rate of discovery of new genetic markers, it is important that genetic laboratories adapt quickly and provide cost-effective solutions for producers to take advantage of this","og_url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/","og_site_name":"Behind the Bench","article_publisher":"https:\/\/www.facebook.com\/thermofisher","article_published_time":"2018-09-12T16:40:23+00:00","article_modified_time":"2018-10-18T23:49:14+00:00","og_image":[{"width":1065,"height":596,"url":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","type":"image\/png"}],"author":"Behind The Bench Staff","twitter_card":"summary_large_image","twitter_creator":"@thermofisher","twitter_site":"@thermofisher","twitter_misc":{"Written by":"Behind The Bench Staff","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/"},"author":{"name":"Behind The Bench Staff","@id":"https:\/\/admin.acceleratingscience.com\/behindthebench\/#\/schema\/person\/9bbb2d67616274d3d4a21a584f7f4a0c"},"headline":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs","datePublished":"2018-09-12T16:40:23+00:00","dateModified":"2018-10-18T23:49:14+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/"},"wordCount":693,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","keywords":["sequencing"],"articleSection":["Animal Health and AgriGenomics"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/","url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/","name":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs - Behind the Bench","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/behindthebench\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","datePublished":"2018-09-12T16:40:23+00:00","dateModified":"2018-10-18T23:49:14+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/behindthebench\/#\/schema\/person\/9bbb2d67616274d3d4a21a584f7f4a0c"},"breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","contentUrl":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","width":1065,"height":596},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/targeted-gbs-flexibility-accelerates-genomic-breeding-programs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/behindthebench\/"},{"@type":"ListItem","position":2,"name":"Targeted GBS Flexibility Accelerates Genomic Breeding Programs"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/behindthebench\/#website","url":"https:\/\/admin.acceleratingscience.com\/behindthebench\/","name":"Behind the Bench","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/behindthebench\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/behindthebench\/#\/schema\/person\/9bbb2d67616274d3d4a21a584f7f4a0c","name":"Behind The Bench Staff","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/52d5c16ece4bd1c0a49a63521c2b6a25c54a3f0c33f7afed215ba7e0cdff69e3?s=96&d=mm&r=g","caption":"Behind The Bench Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/behind-the-bench-staff\/"}]}},"taxonomy_info":{"category":[{"value":83,"label":"Animal Health and AgriGenomics"}],"post_tag":[{"value":74,"label":"sequencing"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen-1024x573.png",760,425,true],"author_info":{"display_name":"Behind The Bench Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/behind-the-bench-staff\/"},"comment_info":0,"category_info":[{"term_id":83,"name":"Animal Health and AgriGenomics","slug":"animal-health-and-agrigenomics","term_group":0,"term_taxonomy_id":83,"taxonomy":"category","description":"","parent":0,"count":65,"filter":"raw","meta":[],"cat_ID":83,"category_count":65,"category_description":"","cat_name":"Animal Health and AgriGenomics","category_nicename":"animal-health-and-agrigenomics","category_parent":0}],"tag_info":[{"term_id":74,"name":"sequencing","slug":"sequencing","term_group":0,"term_taxonomy_id":74,"taxonomy":"post_tag","description":"","parent":0,"count":158,"filter":"raw","meta":[]}],"jetpack-related-posts":[{"id":19447,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/philadelphia-chromosome-like-all-digital-pcr\/","url_meta":{"origin":11591,"position":0},"title":"Unlocking Cancer\u2019s Genetic Secrets with Digital PCR","author":"Behind The Bench Staff","date":"February 27, 2026","format":false,"excerpt":"In this episode of Absolute Gene-ius, we explore how digital PCR (dPCR) is transforming leukemia research with Valeria Rangel, a PhD candidate at the University of California, Irvine. Her work focuses on Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia (ALL), a rare, aggressive subtype that disproportionately affects Hispanic populations. By\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/RANGEL-headshot-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/RANGEL-headshot-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/RANGEL-headshot-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/RANGEL-headshot-1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":19232,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/early-molecular-relapse-detection-dpcr\/","url_meta":{"origin":11591,"position":1},"title":"Following the Molecular Fingerprints of Cancer with Digital PCR","author":"Behind The Bench Staff","date":"November 11, 2025","format":false,"excerpt":"https:\/\/www.youtube.com\/watch?v=vbta1TG617s For clinical researchers and scientists, the value of a biomarker depends on its accurate measurement and trackability over time. Digital PCR (dPCR) delivers both. At Tata Medical Center, Dr. Mayur Parihar, Senior Consultant in Hematology and Cytogenetics and Clinical Research Scientist at the Tata Translational Cancer Research Center, recognizes\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Pathologist preparing a molecular diagnostic sample in a clinical laboratory to support precision oncology decision-making.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/LC-Blog_Preferred-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/LC-Blog_Preferred-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/LC-Blog_Preferred-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/LC-Blog_Preferred-1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":19885,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/sanger-sequencing-mix-dna-templates\/","url_meta":{"origin":11591,"position":2},"title":"Advancing the Gold Standard: Faster, Smarter, and Built for Challenging Templates","author":"Behind The Bench Staff","date":"August 5, 2026","format":false,"excerpt":"Sanger sequencing has long been the gold standard for accuracy, trusted by laboratories worldwide for applications ranging from plasmid verification to confirming next-generation sequencing results. Yet as research evolves, so do the demands placed on sequencing workflows. Today\u2019s labs are not only looking for accuracy\u2014they need speed, flexibility, and reliable\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"DNA sequencing sample tube with DNA helix and sequencing chromatogram representing Sanger sequencing workflow.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19805,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/liquid-biopsy-workflow-standardization\/","url_meta":{"origin":11591,"position":3},"title":"Improving the Reliability of Liquid Biopsy in Real-World Settings Through Workflow Standardization: A Discussion with Dr. Matteo Allegretti","author":"Ashleigh Barlow","date":"June 18, 2026","format":false,"excerpt":"Liquid biopsy offers a powerful, noninvasive way to detect and track cancer, but ensuring reliability in real-world settings remains a key hurdle. Variability in workflows and the need for robust verification steps limit widespread adoption. Dr. Matteo Allegretti, Senior Researcher at the Translational Oncology Research Unit at the IRCCS Regina\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Research scientist operating laboratory equipment during liquid biopsy and biomarker research.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":19235,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/crispr-digital-pcr-gene-editing-workflow\/","url_meta":{"origin":11591,"position":4},"title":"Revolutionizing Gene Editing with CRISPR and Digital PCR &#8211; A Conversation with Dr. Dustin Rubinstein","author":"Behind The Bench Staff","date":"November 11, 2025","format":false,"excerpt":"In a recent Absolute Gene-ius podcast episode titled \u201cCRISPR, dPCR, and pigs - a cut above the rest\u201d, Dr. Dustin Rubinstein, Director of the Advanced Genome Editing Laboratory at the University of Wisconsin-Madison, shared his insights on how CRISPR and digital PCR (dPCR) are revolutionizing gene editing workflows. This Q&A\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19645,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/aav-viral-vector-analytics-cdmo\/","url_meta":{"origin":11591,"position":5},"title":"Almost a Virus: How CDMOs Enable Scalable Cell and Gene Therapy","author":"Behind The Bench Staff","date":"April 6, 2026","format":false,"excerpt":"In this episode of Absolute Gene-ius, Dr. Dan Mitchell, Senior Director of Analytical Development and Quality Control at Matica Biotechnology, explains how contract development and manufacturing organizations (CDMOs) support the advancement of cell and gene therapies. The discussion focuses on viral vector development, analytical strategies, and the technologies used to\u2026","rel":"","context":"In &quot;Pharma &amp; Biotech Manufacturing&quot;","block_context":{"text":"Pharma &amp; Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"Headshot of a man with dark hair and a beard wearing a suit and tie against a neutral background.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/DMitchell-Headshot-1_Jordan-Ruggieri.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2018\/09\/Aaron-Larsen.png","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts\/11591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/users\/120"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/comments?post=11591"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts\/11591\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/media\/11594"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/media?parent=11591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/categories?post=11591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/tags?post=11591"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/division?post=11591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}