{"id":13615,"date":"2020-05-15T00:17:21","date_gmt":"2020-05-15T00:17:21","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/?p=13615"},"modified":"2020-05-15T04:01:26","modified_gmt":"2020-05-15T04:01:26","slug":"help-for-difficult-to-pipette-samples","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/help-for-difficult-to-pipette-samples\/","title":{"rendered":"Help for difficult-to-pipette samples"},"content":{"rendered":"

Have you ever tried pipetting a viscous solution, only to find that your pipette could not accurately draw up the solution? Have you worried about damaging fragile cells or unstable molecular complexes when pipetting?<\/p>\n

If you are working with samples that are difficult to pipette or can be damaged by pipetting, you should consider using wide bore pipette tips.<\/p>\n

Wide bore pipette tips<\/strong><\/p>\n

Wide bore pipette tips are equipped with a distal end orifice that is nearly 70% larger than that of a standard pipette tip. These tips provide the added flexibility required for handling difficult-to-pipette samples.<\/p>\n

 <\/p>\n

<\/p>\n

Thermo Scientific\u2122 ART\u2122 Wide Bore Pipette Tips<\/a> seal when exposed to potential contaminants, trapping them inside the barrier. Wide bore pipette tips are available in different volumes (200\u20131,000 mL) and packaging options (bulk, racked, nonsterile, sterile, non-filtered, and filtered).<\/p>\n

Wide bore pipette tips are especially useful for the following applications:<\/p>\n

Genomic DNA (gDNA) <\/strong><\/p>\n

Pipetting alone can shear gDNA and should be considered when considering a protocol that will include the transfer of gDNA. A wide bore pipette tip will keep the gDNA more intact and lessen the chance of shearing during pipetting.<\/p>\n

Cellular materials <\/strong><\/p>\n

When working with fragile cellular samples such as macrophages, hybridomas, or hepatocytes, cellular damage is a big concern. Using a pipette tip that will not damage cells passing through the distal end should be considered in order to protect the cells during transfer.<\/p>\n

Viscous samples<\/strong><\/p>\n

For those working with viscous solutions, the wider opening allows thicker, more viscous liquids to pass through by lowering the pressure needed for movement through the orifice and into the shaft of the tip.\u00a0 In general, by lowering the pressure needed to pass the sample through the orifice, the resistance of flow is decreased, and less stress is put on the sample during liquid handling.<\/p>\n

Particulate samples<\/strong><\/p>\n

Using a wide bore pipette tip for samples that have particles (e.g., environmental\/food-derived samples, beads, etc.) can prevent blockage in the distal end of the tip during pipetting. The user can save time, repeat pipetting, and prevent contamination of sample or pipette shaft with use of a wide bore pipette tip.<\/p>\n

Additional considerations when using wide bore tips<\/strong><\/p>\n

It is always important to check the performance of your pipette and tips prior to use so that any adjustments can be made to obtain the best accuracy and precision. Also, there are different pipetting techniques that can be performed to better handle difficult-to-pipette samples. Please refer to the fundamentals of pipetting practices online guide<\/a> for a comprehensive overview of pipetting techniques to improve your pipetting in the lab.<\/p>\n

To find out more about Thermo Scientific ART Pipette Tips, visit thermofisher.com\/art<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Have you ever tried pipetting a viscous solution, only to find that your pipette could not accurately draw up the solution? Have you worried about damaging fragile cells or unstable molecular complexes when pipetting? If you are working with samples that are difficult to pipette or can be damaged by pipetting, you should consider using<\/p>\n","protected":false},"author":120,"featured_media":13613,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[108],"tags":[],"division":[],"class_list":{"0":"post-13615","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-lab-tips-and-tricks","8":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\nHelp 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(1,2) Because cancer\u2026","rel":"","context":"In "Cancer Research"","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Scientist pipetting a laboratory sample during molecular biomarker research.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":19883,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/building-a-better-sample-qc-workflow-from-extraction-to-sequencing\/","url_meta":{"origin":13615,"position":2},"title":"Building a Better Sample QC Workflow: From Extraction to Sequencing","author":"Marlene Gasdia-Cochrane","date":"August 25, 2026","format":false,"excerpt":"Article Summary Successful genomics experiments don't begin with sequencing\u2014they begin with sample quality. Every downstream application, from PCR to next-generation sequencing (NGS), depends on starting with nucleic acids that are accurately quantified and free from contaminants that could compromise results. Establishing a consistent quality control workflow helps laboratories improve reproducibility\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"A pipette drops a liquid into a petri dish with a dna sequence background, science concept. 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Yet as research evolves, so do the demands placed on sequencing workflows. Today\u2019s labs are not only looking for accuracy\u2014they need speed, flexibility, and reliable\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"DNA sequencing sample tube with DNA helix and sequencing chromatogram representing Sanger sequencing workflow.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19805,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/liquid-biopsy-workflow-standardization\/","url_meta":{"origin":13615,"position":4},"title":"Improving the Reliability of Liquid Biopsy in Real-World Settings Through Workflow Standardization: A Discussion with Dr. Matteo Allegretti","author":"Ashleigh Barlow","date":"June 18, 2026","format":false,"excerpt":"Liquid biopsy offers a powerful, noninvasive way to detect and track cancer, but ensuring reliability in real-world settings remains a key hurdle. Variability in workflows and the need for robust verification steps limit widespread adoption. Dr. Matteo Allegretti, Senior Researcher at the Translational Oncology Research Unit at the IRCCS Regina\u2026","rel":"","context":"In "Cancer Research"","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Research scientist operating laboratory equipment during liquid biopsy and biomarker research.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/Allegretti-Header.png?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":19585,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/advanced-verification-in-pharmaceutical-manufacturing-using-raman-spectroscopy\/","url_meta":{"origin":13615,"position":5},"title":"Advanced Verification in Pharmaceutical Manufacturing Using Raman Spectroscopy","author":"Marlene Gasdia-Cochrane","date":"April 21, 2026","format":false,"excerpt":"Article Summary Pharmaceutical manufacturing relies on strict quality control to ensure that every product released to the market is safe, effective, and compliant with regulatory standards. Analytical testing plays a critical role in verifying product identity, composition, and consistency. Among modern analytical techniques, Raman spectroscopy stands out as a powerful\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Syringes, injection bottles and tablets lying on the table. Close-up, indoors, view from above. Day light, studio photo. 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