{"id":14078,"date":"2020-06-15T21:40:50","date_gmt":"2020-06-15T21:40:50","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/?p=14078"},"modified":"2021-04-09T16:12:06","modified_gmt":"2021-04-09T16:12:06","slug":"link-between-sars-cov-2-and-mis-c","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/link-between-sars-cov-2-and-mis-c\/","title":{"rendered":"Link between SARS-CoV-2 and MIS-C"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-content\/uploads\/sites\/9\/2020\/06\/sars-mis-c_small-1.jpg\" style=\"float: right;margin: 5px\" alt=\"SARS-CoV-2 &amp; MIS-C\" title=\"SARS &amp; MIS-C\" width=\"450\" height=\"300\" class=\"alignright\" \/>SARS-CoV-2 is rarely found in children, with only about 350 confirmed cases among 4 million total cases worldwide as of May 2020. However, a significant number of children and adolescents in Europe and North America who have been affected by SARS-CoV-2 end up with a complex autoimmune condition. The novel multisystem inflammatory syndrome in children (MIS-C) is a rare and dangerous inflammatory condition that can follow a SARS-CoV-2 infection, with overlapping symptoms for Kawasaki disease. Unlike Kawasaki disease however, which tends to primarily affect toddlers, MIS-C appears in older children with more severity, resulting with the inflammation of blood vessels throughout the body, affecting lymph nodes, heart, lungs, kidneys, brain, eyes, skin or gastrointestinal organs. The direct cause of MIS-C is unclear, however it is believed to be an immune response triggered by SARS-CoV-2 since many of the MIS-C samples are from a population that previously had the virus or were in close proximity with someone who was infected.<\/p>\n<p>There is still much to be discovered about the relationship between SARS-CoV-2 and MIS-C:<\/p>\n<ul>\n<li>Do children have more efficient immune systems to defend against SARS-CoV-2?<\/li>\n<li>What characteristics of a population is more prone to MIS-C?<\/li>\n<li>What changes in the immune system influence a sub-population&rsquo;s susceptibility to MIS-C?<\/li>\n<li>Are there specific host immune responses that are triggered by the SARS-CoV-2 virus that lead to MIS-C?<\/li>\n<\/ul>\n<p>As MIS-C is likely a result from adverse immune responses, a survey of the immune repertoire could shed some light on the condition, with the hope of understanding its relationship with SARS-CoV-2. <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">Targeted next-generation sequencing (NGS)<\/a> is a versatile tool for studying infectious diseases like SARS-CoV-2, because it can be used for research of viral biology and immune response including:<\/p>\n<ul>\n<li>Complete coverage of the SARS-CoV-2 genome and variants for <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/dna-sequencing\/microbial-sequencing\/microbial-identification-ion-torrent-next-generation-sequencing\/viral-typing\/coronavirus-research.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">coronavirus typing, discovery and epidemiology<\/a> to trace genetic diversity and evolution of the virus<\/li>\n<li>Molecular profiling of the <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/dna-sequencing\/microbial-sequencing\/microbial-identification-ion-torrent-next-generation-sequencing\/immune-response-targeted-ngs.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">immune repertoire (BCR IGH and TCR beta)<\/a> for a deeper understanding of the composition and history of the immune system<\/li>\n<li>Studying additional factors like <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/rna-sequencing\/transcriptome-sequencing\/transcriptome-sequencing-ion-torrent-next-generation-sequencing.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">gene expression<\/a> and <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/dna-sequencing\/microbial-sequencing\/microbial-identification-ion-torrent-next-generation-sequencing\/ion-ampliseq-microbiome-health-research-kit.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">microbiota<\/a>, which also influence immune responses to pathogen infection<\/li>\n<\/ul>\n<p>It is clear that more research can enable a more complete picture of the correlation or causation of infectious agents and inflammatory syndromes like MIS-C.<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/products-and-services\/promotions\/life-science\/ngs-solutions-sars-cov-2-research.html?cid=csd_ngs_sbu_r01_co_cp1347_pjt5732_col000000_0so_blg_op_edu_at_s00_SARSMIS-C\" target=\"_blank\" rel=\"noopener noreferrer\">Learn more about Ion Torrent targeted NGS for SARS-CoV-2 Research<\/a><\/p>\n<p><strong>Research Use Only. Not for use in diagnostic procedures<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2 is rarely found in children, with only about 350 confirmed cases among 4 million total cases worldwide as of May 2020. However, a significant number of children and adolescents in Europe and North America who have been affected by SARS-CoV-2 end up with a complex autoimmune condition. The novel multisystem inflammatory syndrome in children<\/p>\n","protected":false},"author":120,"featured_media":14082,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[185],"tags":[1353,2221,2127,1352,2125],"division":[],"class_list":{"0":"post-14078","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-complex-diseases","8":"tag-covid-19","9":"tag-csd","10":"tag-ion-sarshost","11":"tag-sars-cov-2","12":"tag-sarscov2-ngs-edu","13":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- 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This Q&A\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/11\/S3-E1-Header-Image-1_Jordan-Ruggieri-scaled.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19509,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/cfdna-fragmentomics-analysis-qpcr-cancer-monitoring\/","url_meta":{"origin":14078,"position":1},"title":"qPCR-based fragmentomics for monitoring cancer disease progression","author":"Behind The Bench Staff","date":"March 5, 2026","format":false,"excerpt":"As fragmentomics gains momentum in cancer liquid biopsy research, attention is increasingly turning to how these structural cfDNA signals can be measured in a way that is both sensitive and practical. 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Circulating microRNAs (miRNAs) offer that opportunity, serving as potentially stable, non-invasive biomarkers linked to disease progression and therapeutic response; however, their adoption in routine practice remains constrained by technical hurdles. (1,2) Because cancer\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Scientist pipetting a laboratory sample during molecular biomarker research.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":19783,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/what-does-scale-up-look-like-when-volume-is-not-the-goal\/","url_meta":{"origin":14078,"position":3},"title":"What Does Scale-Up Look Like When Volume is Not the Goal?","author":"Marlene Gasdia-Cochrane","date":"June 9, 2026","format":false,"excerpt":"Overview Pharmaceutical scale-up should not always be judged based on increased production volume. While traditional manufacturing focuses on larger equipment and higher throughput, many specialized pharmaceutical programs utilize continuous manufacturing and face different constraints. In these cases, successful scale-up is measured by maintaining process consistency, reproducibility, and control rather than\u2026","rel":"","context":"In &quot;Pharma &amp; Biotech Manufacturing&quot;","block_context":{"text":"Pharma &amp; Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"A pill on blue background","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19748,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/andes-virus-rt-qpcr-detection-workflow\/","url_meta":{"origin":14078,"position":4},"title":"Responding to Hantavirus: Advancing Rapid Molecular Detection","author":"Behind The Bench Staff","date":"May 14, 2026","format":false,"excerpt":"Article Summary Laboratories responding to the emerging 2026 Andes hantavirus incident need rapid, scalable molecular workflows that can integrate into existing RT-qPCR infrastructure. 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By combining\u2026","rel":"","context":"In &quot;Infectious Diseases&quot;","block_context":{"text":"Infectious Diseases","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/infectious-diseases\/"},"img":{"alt_text":"Illustration of hantavirus transmission showing rodent-derived viral particles entering the human respiratory system.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/05\/Hantavirus-3-1_Geoffrey-Cassell.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/05\/Hantavirus-3-1_Geoffrey-Cassell.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/05\/Hantavirus-3-1_Geoffrey-Cassell.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/05\/Hantavirus-3-1_Geoffrey-Cassell.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/05\/Hantavirus-3-1_Geoffrey-Cassell.png?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":19888,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/streptococcus-pneumoniae-serotype-identification-qpcr-nested-pcr\/","url_meta":{"origin":14078,"position":5},"title":"qPCR, Nested PCR, and the Search for Bacterial Serotypes","author":"Ashleigh Barlow","date":"August 5, 2026","format":false,"excerpt":"Article Summary In this episode of Absolute Gene-ius, Donna Paznar, former Head of Molecular Infection Diagnostics at the Medical University of Vienna, discusses her research on Streptococcus pneumoniae and its impact across the Austrian population. She explains why children can act as asymptomatic reservoirs, why tracking bacterial serotypes matters, and\u2026","rel":"","context":"In &quot;Infectious Diseases&quot;","block_context":{"text":"Infectious Diseases","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/infectious-diseases\/"},"img":{"alt_text":"Donna Paznar discussing molecular methods for identifying Streptococcus pneumoniae serotypes.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/Paznar_Headshot_Jordan-Ruggieri-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2020\/06\/sars-mis-c_small-1.jpg","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts\/14078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/users\/120"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/comments?post=14078"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/posts\/14078\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/media\/14082"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/media?parent=14078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/categories?post=14078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/tags?post=14078"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/wp-json\/wp\/v2\/division?post=14078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}