{"id":17723,"date":"2023-03-23T14:00:45","date_gmt":"2023-03-23T14:00:45","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/behindthebench\/?p=17723"},"modified":"2023-03-23T14:15:00","modified_gmt":"2023-03-23T14:15:00","slug":"process-analysis-technologies-discussed-at-asias-biologics-manufacturing-show","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/process-analysis-technologies-discussed-at-asias-biologics-manufacturing-show\/","title":{"rendered":"Process Analysis Technologies Discussed at Asia\u2019s Biologics Manufacturing Show"},"content":{"rendered":"

\"VaccineThe Biologics Manufacturing Asia trade show, known as BMA 2023<\/a>, prides itself on showcasing the latest innovations driving the APAC biologics manufacturing industry, and at this year\u2019s event in Singapore, there were plenty of networking and technical discussions around that subject.<\/p>\n

At the mid-March event, there were over 1,000 attendees, 300 companies, 60 speakers, and 50 case studies focused on the latest biotech manufacturing technologies<\/a>.\u00a0 The show website named several topics that were discussed and demonstrated such as \u201csingle-use and end-to-end continuous processing for biologics, today\u2019s challenges and opportunities in biomanufacturing, advances in upstream process development, cost-optimization strategies in downstream processing, analytical characterization strategies, facility design, and scale-up strategy, fill & finish innovation to streamline the operations amongst other crucial themes.\u201d<\/p>\n

Attendees who stopped by our booth were interested in Process Analytical Technology<\/a> and automated real-time process monitoring, as many of them are still using manual methods.<\/p>\n

Process Analytical Technology<\/a> (PAT), which is a regulatory framework initiated by the United States Food and Drug Administration (FDA), encourages pharmaceutical manufacturers to improve the process of pharmaceutical development, manufacturing, and quality control. PAT aims to improve process efficiency and process control by defining Critical Process Parameters (CPP) and monitoring these CPPs to stay within a defined limit, either in-line or on-line to maintain a product\u2019s Critical Quality Attributes (CQA).<\/p>\n

We demonstrated two PAT categories and resources at the show, including off-gas analysis using process mass spectrometry<\/a> and metabolite monitoring using Raman spectroscopy. Controlling manufacturing by testing and measuring during the processing of critical quality and performance attributes of raw and in-process materials helps ensure final product quality. Real time off-gas monitoring provides insightful data that can be used to determine metabolism. Process mass spectrometers can help track fermentation and cell culture processes in real time and help produce quantitative solvent drying data to optimize the drying process. Process gas analysis technologies deliver lab-quality online gas composition analysis and help maximize product yield and profitability.<\/p>\n

Monitoring CPPs with process mass spectrometry gas analysis reduces over-processing, pinpoints contaminants and increases product consistency. In some cell culture analysis, like mammalian cell fermentations, the feed gas composition is a frequently changing mixture of several compounds. The feed gas concentration also ranges vary dramatically. The implementation of real-time, off-gas analysis using process mass spectrometry<\/a> in mammalian cell culture can help identify process deviations during bioreactor runs and evaluate batch to batch variation, within predefined specifications, for robust manufacturing.<\/p>\n

In biopharmaceutical production, cells require a feeding cycle of glucose to enable cell reproduction. A process analyzer<\/a> utilizing Raman Spectroscopy leverages compact and simplified hardware along with data science tools to model the glucose content of a bioprocess and tell you exactly when to add more glucose to ensure cell production at a precise rate.<\/p>\n

Another technology that has been effectively deployed by the pharmaceutical and biotech industry to identify and quantify unknown materials is a molecular analysis technique called Raman spectroscopy<\/a>. Using this technology, an unknown sample of material is illuminated with monochromatic (single wavelength or single frequency) laser light, which can be absorbed, transmitted, reflected, or scattered by the sample. Light scattered from the sample is due to either elastic collisions of the light with the sample’s molecules (Rayleigh scatter) or inelastic collisions (Raman scatter). Whereas Rayleigh scattered light has the same frequency (wavelength) of the incident laser light, Raman scattered light returns from the sample at different frequencies corresponding to the vibrational frequencies of the bonds of the molecules in the sample.<\/p>\n

Luckily, some of these technologies are designed for out-of-the-box use, enabling one to take highly accurate Raman measurements at the point of need in less than 15 minutes, and can be easily integrated into existing process monitoring and eliminates the need for costly technical expertise.<\/p>\n

If you weren\u2019t able to make the show, and want to learn more about these and other applied technologies to improve pharmaceutical and biotech manufacturing processes<\/a>, just visit our website. Don\u2019t wait for next year\u2019s show (date and place to be determined).<\/p>\n","protected":false},"excerpt":{"rendered":"

The Biologics Manufacturing Asia trade show, known as BMA 2023, prides itself on showcasing the latest innovations driving the APAC biologics manufacturing industry, and at this year\u2019s event in Singapore, there were plenty of networking and technical discussions around that subject. At the mid-March event, there were over 1,000 attendees, 300 companies, 60 speakers, and<\/p>\n","protected":false},"author":1710,"featured_media":17724,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[172,1087],"tags":[236,2240,2339,2337,2338,2340],"division":[],"class_list":{"0":"post-17723","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-general","8":"category-pharmamfg","9":"tag-biopharma","10":"tag-biotech","11":"tag-pat","12":"tag-pharmamanufacturing","13":"tag-process-mass-spectrometry","14":"tag-processanalyticaltechnology","15":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\nProcess Analysis Technologies Discussed at Asia\u2019s Biologics Manufacturing Show - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/process-analysis-technologies-discussed-at-asias-biologics-manufacturing-show\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Process Analysis Technologies Discussed at Asia\u2019s Biologics Manufacturing Show\" \/>\n<meta property=\"og:description\" content=\"The Biologics Manufacturing Asia trade show, known as BMA 2023, prides itself on showcasing the latest innovations driving the APAC biologics manufacturing industry, and at this year\u2019s event in Singapore, there were plenty of networking and technical discussions around that subject. 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Highly sensitive cells whose quality, safety, and efficacy depend on careful handling at every step of the manufacturing\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Scientist working in a lab","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/07\/Hero_image_1920x1080.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19801,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/how-process-analytical-technology-enables-real-time-quality-control-in-pharmaceutical-manufacturing\/","url_meta":{"origin":17723,"position":1},"title":"How Process Analytical Technology Enables Real-time Quality Control in Pharmaceutical Manufacturing","author":"Marlene Gasdia-Cochrane","date":"July 7, 2026","format":false,"excerpt":"Article Summary Process analytical technology (PAT) is transforming pharmaceutical manufacturing by enabling real-time monitoring, process understanding, and quality control throughout the production lifecycle. By combining advanced analytics, in-line sensors, data modeling, and automation, PAT helps manufacturers identify critical process parameters (CPPs), improve product quality, reduce deviations, and support real-time release\u2026","rel":"","context":"In "Pharma & Biotech Manufacturing"","block_context":{"text":"Pharma & Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"test tubes and pharmaceutical products","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1025828074_pat-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19353,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/manufacturing-strategy-in-pharma-scale-up-vs-scale-out-for-continuous-processes\/","url_meta":{"origin":17723,"position":2},"title":"Scale-Up vs. Scale-Out Strategies for Continuous Pharma Manufacturing","author":"Marlene Gasdia-Cochrane","date":"February 3, 2026","format":false,"excerpt":"As pharmaceutical pipelines evolve, manufacturing strategies are being tested in new ways. Drug candidates are more complex, development timelines are tighter, and expectations for quality and consistency continue to rise. Against this backdrop, one question comes up repeatedly for formulation and manufacturing teams:\u00a0should we scale up, or should we scale\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Sorting pharmaceutical capsules by a sorting machine on a production line","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":20039,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/building-more-robust-raman-calibration-models-for-bioprocess-monitoring\/","url_meta":{"origin":17723,"position":3},"title":"Building More Robust Raman Calibration Models for Bioprocess Monitoring","author":"Marlene Gasdia-Cochrane","date":"October 20, 2026","format":false,"excerpt":"Article Summary Raman spectroscopy enables real-time bioprocess monitoring by translating spectral data into information about critical process components. Robust Raman calibration models depend on representative datasets that capture relevant concentration ranges and real process variability. Combining Uniform Design experiments with targeted in-process data can expand calibration coverage while reducing the\u2026","rel":"","context":"In "Pharma & Biotech Manufacturing"","block_context":{"text":"Pharma & Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"Close-up of a high-tech assembly line in a pharmaceutical production plant, showcasing automation technology with bottles and vials being processed at high precision.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/10\/iStock-2213180417.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19585,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/advanced-verification-in-pharmaceutical-manufacturing-using-raman-spectroscopy\/","url_meta":{"origin":17723,"position":4},"title":"Advanced Verification in Pharmaceutical Manufacturing Using Raman Spectroscopy","author":"Marlene Gasdia-Cochrane","date":"April 21, 2026","format":false,"excerpt":"Article Summary Pharmaceutical manufacturing relies on strict quality control to ensure that every product released to the market is safe, effective, and compliant with regulatory standards. Analytical testing plays a critical role in verifying product identity, composition, and consistency. Among modern analytical techniques, Raman spectroscopy stands out as a powerful\u2026","rel":"","context":"In "General"","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Syringes, injection bottles and tablets lying on the table. Close-up, indoors, view from above. Day light, studio photo. Healthcare concept","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/04\/iStock-1355152090.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19658,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/is-raman-spectroscopy-a-better-verification-method-in-pharmaceutical-manufacturing\/","url_meta":{"origin":17723,"position":5},"title":"Is Raman Spectroscopy a Better Verification Method in Pharmaceutical Manufacturing?","author":"Marlene Gasdia-Cochrane","date":"May 5, 2026","format":false,"excerpt":"Article Summary Verification testing is a critical step in pharmaceutical manufacturing, helping to ensure that every product released meets strict safety, quality, and regulatory standards. Verification helps ensure that products contain the correct active ingredients, meet concentration specifications, are free from contamination, and maintain structural and chemical integrity. This process\u2026","rel":"","context":"In "Pharma & Biotech Manufacturing"","block_context":{"text":"Pharma & Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"Yellow pill and red check mark sitting on brown wood surface in front of abstract defocused background. Horizontal composition with selective focus and copy space. Front view. 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