{"id":19109,"date":"2025-09-02T08:00:00","date_gmt":"2025-09-02T08:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/?p=19109"},"modified":"2025-09-03T19:08:22","modified_gmt":"2025-09-03T19:08:22","slug":"twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\/","title":{"rendered":"Twin-Screw Granulation in Oral Solid Dosage Manufacturing \u2013 Process, Benefits &amp; Optimization"},"content":{"rendered":"\n<p>Oral solid dosage forms, such as tablets and capsules, are among the most common and preferred methods of drug delivery due to their convenience, stability, and patient compliance.<\/p>\n\n\n\n<p>The <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">production of these pharmaceuticals<\/a> requires precise control and optimization of several processes, from raw material preparation to final packaging. Understanding these stages is crucial to help ensure efficacy, safety, and quality. In this article, we explore the various stages of manufacturing oral solid dosage pharmaceuticals, highlighting <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">twin-screw granulation<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-key-processes-in-the-production-of-oral-solid-dosage-pharmaceuticals\">Key processes in the production of oral solid dosage pharmaceuticals<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Raw material preparation: <\/strong>The first step in the production process is the preparation of raw materials, including active pharmaceutical ingredients (APIs) and excipients. These materials must be accurately weighed, milled, and blended to achieve uniformity. Proper handling and storage are essential to maintain their stability and prevent contamination.<\/li>\n\n\n\n<li><strong>Granulation: <\/strong><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">Granulation<\/a> is a critical process that involves the aggregation of powder particles to form granules. This can be achieved through various methods, such as wet granulation, dry granulation, and twin-screw granulation. Granulation improves the flow properties of the powder, enhances compressibility, and helps ensure uniform distribution of the API.\n<ul class=\"wp-block-list\">\n<li><strong style=\"color: initial\">Dry granulation<\/strong><span style=\"color: initial\">: Involves compressing powder into slugs or sheets and then milling them into granules. <\/span><\/li>\n\n\n\n<li><strong style=\"color: initial\">Wet granulation<\/strong><span style=\"color: initial\">: Uses a liquid binder to agglomerate powder particles, followed by <\/span><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/solutions.html?icid=CAD_blog_LSM_2025Sept#solvent\" target=\"_blank\" rel=\"noreferrer noopener\">drying<\/a><span style=\"color: initial\">.<\/span><\/li>\n\n\n\n<li><strong>Twin-screw granulation<\/strong>: Utilizes twin-screw <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies.html?icid=CAD_blog_LSM_2025Sept#extrusion-compounding\" target=\"_blank\" rel=\"noreferrer noopener\">extruders<\/a> to continuously mix and granulate materials.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Blending: <\/strong>After granulation, the granules are blended with excipients to help ensure uniform distribution of the API and achieve the desired properties. Blending must be controlled to prevent segregation and achieve homogeneity.<\/li>\n\n\n\n<li><strong>Compression: <\/strong>The blended granules are compressed into tablets using a tablet press, forming tablets of specific shape, size, and hardness. Compression parameters must be optimized for integrity and dissolution properties.<\/li>\n\n\n\n<li><strong>Coating: <\/strong>Tablets may be coated to enhance appearance, mask taste, protect the API, and control drug release. Common techniques include film and sugar coating. Coating solutions are sprayed and dried to form a uniform layer.<\/li>\n\n\n\n<li><strong>Encapsulation<\/strong>: For capsules, granules or powder are filled into gelatin or HPMC shells, ensuring precise dosage and protecting the API from degradation.<\/li>\n\n\n\n<li><strong>Quality Control<\/strong>: Rigorous quality control measures help ensure the final product meets standards, including testing for uniformity, potency, dissolution, and stability.<\/li>\n\n\n\n<li><strong>Packaging: <\/strong>The final step is packaging tablets and capsules in blister packs, bottles, or other containers to protect them and help ensure patient convenience, maintaining the integrity and stability of the dosage forms.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-introduction-to-twin-screw-granulation\">Introduction to twin-screw granulation<\/h2>\n\n\n\n<p>As noted, granulation is a critical process in pharmaceutical manufacturing, essential for producing tablets and capsules with the desired properties.<\/p>\n\n\n\n<p>The <a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/553-4040?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">twin-screw granulator<\/a> consists of two screws rotating within a barrel, creating a mixing and granulating zone. The screws&#8217; configuration and speed, along with the feed rate of materials, are critical parameters that influence the granulation process. By optimizing these parameters, manufacturers can achieve the desired granule characteristics. This method contrasts with traditional batch granulation, offering key advantages, including continuous processing and better scalability<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-key-advantages-of-twin-screw-granulation\">Key advantages of twin-screw granulation<\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>Enhanced process control<\/strong>: Twin-screw granulation allows for precise control over the granulation process, leading to consistent product quality. The continuous nature of the process enables real-time monitoring and adjustments, helping to ensure optimal granule size and distribution.<\/li>\n\n\n\n<li><strong>Improved product quality<\/strong>: The uniform mixing and granulation achieved with twin-screw technology result in high-quality granules with excellent flow properties. This consistency translates to better tablet formation and reduced variability in the final product.<\/li>\n\n\n\n<li><strong>Efficiency and scalability<\/strong>: Twin-screw granulation is highly efficient, reducing processing times and material wastage. Its continuous nature makes it easily scalable, accommodating varying production demands without significant changes to the equipment or process.<\/li>\n<\/ol>\n\n\n\n<p><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">Twin-screw granulation<\/a> is particularly beneficial in the production of oral solid dosage forms because it can granulate a wide range of materials, from active pharmaceutical ingredients (APIs) to excipients, helping to ensure uniformity and consistency in the final product.<\/p>\n\n\n\n<p>While twin-screw granulation offers numerous benefits, it also presents certain challenges and considerations. These include the need for specialized equipment and expertise, as well as potential issues with material handling and process optimization. Manufacturers must carefully consider these factors to fully leverage the advantages of twin-screw granulation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-conclusion\">Conclusion<\/h2>\n\n\n\n<p>The production of oral solid dosage pharmaceuticals is a complex and meticulously controlled process that involves multiple stages, from raw material preparation to final packaging. By understanding and optimizing these processes, manufacturers can help ensure the consistent quality, efficacy, and safety of their products.<\/p>\n\n\n\n<p>Twin-screw granulation represents a major advancement in pharmaceutical manufacturing, offering improved process control, product quality, and efficiency. Its applications in producing oral solid dosage forms make it a valuable technique for manufacturers seeking to optimize their production processes. As technology continues to evolve, twin-screw granulation is poised to become even more integral to the pharmaceutical industry.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-additional-resources\">Additional resources<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?tracksrc=IntEm-Button1-1886402&amp;leadsource=Email&amp;C_Campaign_Element=7014z000001pnZpAAI&amp;elqTrackId=d906e53a3034463794d56801ef09928a&amp;elq=030c890862424165b2ca931aed8213dc&amp;elqaid=6638&amp;elqat=1&amp;elqCampaignId=2511&amp;elqak=8AF5AA52347C136C96ABD76E4830368B068B5AF58B191B8845E34D35611AFBA07FEA\">Continuous Manufacturing and Granu<\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?tracksrc=IntEm-Button1-1886402&amp;leadsource=Email&amp;C_Campaign_Element=7014z000001pnZpAAI&amp;elqTrackId=d906e53a3034463794d56801ef09928a&amp;elq=030c890862424165b2ca931aed8213dc&amp;elqaid=6638&amp;elqat=1&amp;elqCampaignId=2511&amp;elqak=8AF5AA52347C136C96ABD76E4830368B068B5AF58B191B8845E34D35611AFBA07FEAicid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">l<\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods\/technologies\/continuous-granulation.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">ation Technology<\/a><\/li>\n\n\n\n<li>White paper: <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/global\/forms\/industrial\/white-paper-continuous-twin-screw-granulation.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">Continuous Twin-Screw Granulation<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.thermofisher.com\/order\/catalog\/product\/553-4040?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">Pharma Twin-Screw Granulator<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods.html?icid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">Technologies and Solutions for Improving Pha<\/a><a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/industrial\/manufacturing-processing\/improving-pharmaceutical-biotech-manufacturing-processes-production-methods.htmlicid=CAD_blog_LSM_2025Sept\" target=\"_blank\" rel=\"noreferrer noopener\">rmaceutical and Biotech Manufacturing Processes<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oral solid dosage forms, such as tablets and capsules, are among the most common and preferred methods of drug delivery due to their convenience, stability, and patient compliance. The production of these pharmaceuticals requires precise control and optimization of several processes, from raw material preparation to final packaging. Understanding these stages is crucial to help<\/p>\n","protected":false},"author":38,"featured_media":19110,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1087],"tags":[2513,2326,2512],"division":[],"class_list":{"0":"post-19109","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-pharmamfg","8":"tag-oral-solid-dosage","9":"tag-pharmaceutical-manufacturing","10":"tag-twin-screw-granulation","11":"entry"},"_selected_authors":[945],"_selected_reviewers":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Twin-Screw Granulation in Oral Solid Dosage Manufacturing \u2013 Process, Benefits &amp; Optimization - Behind the Bench<\/title>\n<meta name=\"description\" content=\"Learn how twin-screw granulation enhances oral solid dosage pharmaceutical production. Discover processes, advantages, and expert tips for optimizing efficiency and product quality.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Twin-Screw Granulation in Oral Solid Dosage Manufacturing \u2013 Process, Benefits &amp; Optimization\" \/>\n<meta property=\"og:description\" content=\"Learn how twin-screw granulation enhances oral solid dosage pharmaceutical production. Discover processes, advantages, and expert tips for optimizing efficiency and product quality.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\/\" \/>\n<meta property=\"og:site_name\" content=\"Behind the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-02T08:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-03T19:08:22+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2025\/08\/iStock-1465073080_pillmfg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2309\" \/>\n\t<meta property=\"og:image:height\" content=\"1299\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Marlene Gasdia-Cochrane\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Marlene Gasdia-Cochrane\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/\"},\"author\":{\"name\":\"Marlene Gasdia-Cochrane\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/11bbcaf39c3abda3e0648991cb0f5ea8\"},\"headline\":\"Twin-Screw Granulation in Oral Solid Dosage Manufacturing \u2013 Process, Benefits &amp; Optimization\",\"datePublished\":\"2025-09-02T08:00:00+00:00\",\"dateModified\":\"2025-09-03T19:08:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/\"},\"wordCount\":820,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2025\\\/08\\\/iStock-1465073080_pillmfg.jpg\",\"keywords\":[\"oral solid dosage\",\"pharmaceutical manufacturing\",\"Twin screw granulation\"],\"articleSection\":[\"Pharma &amp; Biotech Manufacturing\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/\",\"name\":\"Twin-Screw Granulation in Oral Solid Dosage Manufacturing \u2013 Process, Benefits &amp; Optimization - Behind the Bench\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/twin-screw-granulation-in-oral-solid-dosage-manufacturing-process-benefits-optimization\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2025\\\/08\\\/iStock-1465073080_pillmfg.jpg\",\"datePublished\":\"2025-09-02T08:00:00+00:00\",\"dateModified\":\"2025-09-03T19:08:22+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/11bbcaf39c3abda3e0648991cb0f5ea8\"},\"description\":\"Learn how twin-screw granulation enhances oral solid dosage pharmaceutical production. 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While traditional manufacturing focuses on larger equipment and higher throughput, many specialized pharmaceutical programs utilize continuous manufacturing and face different constraints. In these cases, successful scale-up is measured by maintaining process consistency, reproducibility, and control rather than\u2026","rel":"","context":"In &quot;Pharma &amp; Biotech Manufacturing&quot;","block_context":{"text":"Pharma &amp; Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"A pill on blue background","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-1218800138.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19353,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/manufacturing-strategy-in-pharma-scale-up-vs-scale-out-for-continuous-processes\/","url_meta":{"origin":19109,"position":1},"title":"Scale-Up vs. Scale-Out Strategies for Continuous Pharma Manufacturing","author":"Marlene Gasdia-Cochrane","date":"February 3, 2026","format":false,"excerpt":"As pharmaceutical pipelines evolve, manufacturing strategies are being tested in new ways. Drug candidates are more complex, development timelines are tighter, and expectations for quality and consistency continue to rise. Against this backdrop, one question comes up repeatedly for formulation and manufacturing teams:\u00a0should we scale up, or should we scale\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Sorting pharmaceutical capsules by a sorting machine on a production line","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-1499814881.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19792,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/reducing-discontinuities-in-pharmaceutical-scale-up\/","url_meta":{"origin":19109,"position":2},"title":"Reducing Discontinuities in Pharmaceutical Scale-Up","author":"Marlene Gasdia-Cochrane","date":"June 23, 2026","format":false,"excerpt":"Overview Successful pharmaceutical scale-up depends on more than increased production capacity. Continuity across processing parameters or the geometry of equipment is essential. Scale-up challenges often arise when multiple geometric and operational changes are introduced simultaneously, making it difficult to identify the sources of variability. If the material\u2019s processing environment changes,\u2026","rel":"","context":"In &quot;Pharma &amp; Biotech Manufacturing&quot;","block_context":{"text":"Pharma &amp; Biotech Manufacturing","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/pharmamfg\/"},"img":{"alt_text":"Multicolored pills on white background","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/06\/iStock-889516078_pills.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19585,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/advanced-verification-in-pharmaceutical-manufacturing-using-raman-spectroscopy\/","url_meta":{"origin":19109,"position":3},"title":"Advanced Verification in Pharmaceutical Manufacturing Using Raman Spectroscopy","author":"Marlene Gasdia-Cochrane","date":"April 21, 2026","format":false,"excerpt":"Article Summary Pharmaceutical manufacturing relies on strict quality control to ensure that every product released to the market is safe, effective, and compliant with regulatory standards. Analytical testing plays a critical role in verifying product identity, composition, and consistency. Among modern analytical techniques, Raman spectroscopy stands out as a powerful\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Syringes, injection bottles and tablets lying on the table. Close-up, indoors, view from above. Day light, studio photo. 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Medicinal chemists are designing molecules with unprecedented potency and selectivity, enabling therapies that were not possible even a decade ago. Yet despite these scientific gains, many promising drug candidates still struggle to reach patients. One of the most common reasons is poor solubility.\u00a0\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Fizzing Tablet in Water","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/iStock-182713597.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19658,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/is-raman-spectroscopy-a-better-verification-method-in-pharmaceutical-manufacturing\/","url_meta":{"origin":19109,"position":5},"title":"Is Raman Spectroscopy a Better Verification Method in Pharmaceutical Manufacturing?","author":"Marlene Gasdia-Cochrane","date":"May 5, 2026","format":false,"excerpt":"Article Summary Verification testing is a critical step in pharmaceutical manufacturing, helping to ensure that every product released meets strict safety, quality, and regulatory standards. 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