{"id":6372,"date":"2015-10-28T13:39:50","date_gmt":"2015-10-28T17:39:50","guid":{"rendered":"http:\/\/admin.acceleratingscience.com\/?p=6372"},"modified":"2022-08-18T20:29:13","modified_gmt":"2022-08-18T20:29:13","slug":"low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\/","title":{"rendered":"Low Input RNA Sequencing \u2013 RNA:RNA Interactions in Breast Cancer | ASHG 2015"},"content":{"rendered":"<p>Kelli Bramlett of Thermo Fisher Scientific recently spoke with us at the ASHG annual meeting about\u00a0microRNA (miRNA) and mRNA interactions in Breast Cancer.<\/p>\n<p>Her poster, titled \u201c<a href=\"http:\/\/www.slideshare.net\/ThermoFisher\/advances-in-breast-tumor-biomarker-discovery-methods\" target=\"_blank\" rel=\"noopener\">Advances in Breast Tumor Biomarker Discovery Methods<\/a>\u201d explores mRNA and miRNA expressions profiles in breast cancer research samples to potentially identify downstream gene targets that may elicit a disease phenotype.<\/p>\n<p><iframe loading=\"lazy\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/leOWxsUzubI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>They used <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/gene-expression-analysis-genotyping\/laser-capture-microdissection.html?socid=social_btb\" target=\"_blank\" rel=\"noopener\">Laser-capture microdissection<\/a> to collect tumor cells with the ability to spatially locate the cell and its neighboring environment. While traditional RNA sequencing methods require large input amounts, by using the <a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-select-targets\/ampliseq-target-selection\/ampliseq-transcriptome.html?socid=social_btb\" target=\"_blank\" rel=\"noopener\">Ion AmpliSeq<sup>TM<\/sup> transcriptome<\/a> workflow they could start with just 10ng of total RNA input. They were able to prepare two different libraries, one to study mRNA and one for miRNA from the same samples; with technical reproducibility. Their research sheds important light into the world of the complex cancer transcriptomes and biomarker discovery.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kelli Bramlett of Thermo Fisher Scientific recently spoke with us at the ASHG annual meeting about\u00a0microRNA (miRNA) and mRNA interactions in Breast Cancer. Her poster, titled \u201cAdvances in Breast Tumor Biomarker Discovery Methods\u201d explores mRNA and miRNA expressions profiles in breast cancer research samples to potentially identify downstream gene targets that may elicit a disease<\/p>\n","protected":false},"author":120,"featured_media":6373,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[113],"tags":[31,11,74],"division":[],"class_list":{"0":"post-6372","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-events-and-tradeshows","8":"tag-ashg15","9":"tag-ion-torrent","10":"tag-sequencing","11":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Low Input RNA Sequencing \u2013 RNA:RNA Interactions in Breast Cancer | ASHG 2015 - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low Input RNA Sequencing \u2013 RNA:RNA Interactions in Breast Cancer | ASHG 2015\" \/>\n<meta property=\"og:description\" content=\"Kelli Bramlett of Thermo Fisher Scientific recently spoke with us at the ASHG annual meeting about\u00a0microRNA (miRNA) and mRNA interactions in Breast Cancer. Her poster, titled \u201cAdvances in Breast Tumor Biomarker Discovery Methods\u201d explores mRNA and miRNA expressions profiles in breast cancer research samples to potentially identify downstream gene targets that may elicit a disease\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\/\" \/>\n<meta property=\"og:site_name\" content=\"Behind the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2015-10-28T17:39:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-18T20:29:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2015\/11\/ASHG-2015-Photos-for-social-15-1024x683.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Behind The Bench Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Behind The Bench Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/\"},\"author\":{\"name\":\"Behind The Bench Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/#\\\/schema\\\/person\\\/9bbb2d67616274d3d4a21a584f7f4a0c\"},\"headline\":\"Low Input RNA Sequencing \u2013 RNA:RNA Interactions in Breast Cancer | ASHG 2015\",\"datePublished\":\"2015-10-28T17:39:50+00:00\",\"dateModified\":\"2022-08-18T20:29:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/\"},\"wordCount\":160,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/behindthebench\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2015\\\/11\\\/ASHG-2015-Photos-for-social-15.jpg\",\"keywords\":[\"ASHG15\",\"Ion Torrent\",\"sequencing\"],\"articleSection\":[\"Events and Tradeshows\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/behindthebench\\\/low-input-rna-sequencing-rnarna-interactions-in-breast-cancer-ashg-2015\\\/\",\"name\":\"Low Input RNA Sequencing \u2013 RNA:RNA Interactions in Breast Cancer | ASHG 2015 - 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While immunohistochemistry remains central\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Clinical Pathologist in a Molecular Diagnostics Laboratory","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/Bartsch-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/Bartsch-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/Bartsch-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/01\/Bartsch-1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":19911,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/multiplex-mirna-profiling-precision-oncology\/","url_meta":{"origin":6372,"position":1},"title":"A scalable multiplex miRNA profiling workflow for precision oncology research","author":"Ashleigh Barlow","date":"August 18, 2026","format":false,"excerpt":"The promise of precision oncology rests on our ability to reliably monitor tumor biology in real time. 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(1,2) Because cancer\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Scientist pipetting a laboratory sample during molecular biomarker research.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/lisa-blog-picture.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":20004,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/a-guide-to-nucleic-acid-quality-control-dna-and-rna-purity\/","url_meta":{"origin":6372,"position":2},"title":"A Guide to Nucleic Acid Quality Control: DNA and RNA Purity","author":"Marlene Gasdia-Cochrane","date":"September 22, 2026","format":false,"excerpt":"Article Summary Nucleic acid quality control helps researchers evaluate DNA and RNA concentration and purity before downstream applications such as PCR, qPCR, and next-generation sequencing (NGS). A standardized workflow combining reliable extraction, concentration and purity assessment, application-appropriate quantification, and consistent laboratory practices can help identify sample issues early, improve reproducibility,\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"Close-up shot of a dna sequence on a screen, a digital representation of genetic code, used for analysis.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/iStock-2212923489_dnasequence-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":20019,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/qpcr-dpcr-ngs-cancer-research\/","url_meta":{"origin":6372,"position":3},"title":"From tumor heterogeneity to low-frequency variants: How qPCR, dPCR, and NGS work together in cancer research","author":"Ashleigh Barlow","date":"September 26, 2026","format":false,"excerpt":"Dr. Javier Hernandez Losa explains how combining broad genomic profiling with targeted, sensitive confirmation can help researchers address some of cancer biology\u2019s most difficult analytical challenges. A Q&A with Dr. Javier Hernandez Losa, Director of the Molecular Biology Laboratory, Department of Pathology, Hospital Universitario Vall d\u2019Hebron, Barcelona Cancer research increasingly\u2026","rel":"","context":"In &quot;Cancer Research&quot;","block_context":{"text":"Cancer Research","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/cancer-research\/"},"img":{"alt_text":"Dr. Javier Hernandez Losa, Director of the Molecular Biology Laboratory at Hospital Universitario Vall d'Hebron in Barcelona.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/Picture133.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/Picture133.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/Picture133.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/Picture133.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/09\/Picture133.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":19943,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/dna-and-rna-purity-ratios-a260-a280-and-a260-a230-explained\/","url_meta":{"origin":6372,"position":4},"title":"DNA and RNA Purity Ratios: A260\/A280 and A260\/A230 Explained","author":"Marlene Gasdia-Cochrane","date":"September 1, 2026","format":false,"excerpt":"Overview DNA and RNA purity ratios help researchers assess nucleic acid sample quality before downstream analysis. The A260\/A280 ratio can indicate potential protein contamination, while the A260\/A230 ratio can reveal residual salts, phenol, guanidine compounds, and other extraction-related contaminants. 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