{"id":7095,"date":"2016-01-08T13:27:51","date_gmt":"2016-01-08T18:27:51","guid":{"rendered":"http:\/\/admin.acceleratingscience.com\/?p=7095"},"modified":"2018-10-18T23:38:40","modified_gmt":"2018-10-18T23:38:40","slug":"7095","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/7095\/","title":{"rendered":"Evolution of Metagenomic Sequencing"},"content":{"rendered":"<p>Early metagenomic work (before it was even called that) began in the early 1990\u2019s using a single PCR product that was cloned into a bacteriophage and then sequenced on a manual slab gel with radioactive <sup>32<\/sup>P- labeled primers. Anyone remember those days?<\/p>\n<p>The field of metagenomics has been revolutionized by next-gen sequencing as researchers can now look at the diversity of uncultured organisms, from nearly any sample, on a massive scale, detecting millions of sequences from a single sample.<\/p>\n<p>With decades of analysis and hundreds of studies completed, we\u2019ve learned that the diversity of microbes is even greater than expected. And the diversity of those species can tell us much about the health of an ecosystem or how their interactions may be linked to diseases such as IBD, obesity, and chronic wounds.<\/p>\n<p>I<a href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-run-sequence\/ion-pgm-system-for-next-generation-sequencing.html?socid=social_btb\" target=\"_blank\">on Torrent\u2122 sequencing<\/a> offers a complete solution for analyzing these complex metagenomics samples without the need to culture samples and gets you to your answers in less than 3 days time. <a href=\"https:\/\/www.youtube.com\/watch?v=N7tivSQb37k&amp;feature=youtu.be?socid=social_btb\" target=\"_blank\">Watch the video<\/a>\u00a0to learn how clinical researchers and environmental researchers are using the <a href=\"http:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/dna-sequencing\/microbial-sequencing\/microbial-identification-ion-torrent-next-generation-sequencing\/ion-16s-metagenomics-solution.html?socid=social_btb\" target=\"_blank\">Ion 16S\u2122 Metagenomics Kit<\/a> with <a href=\"http:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-data-analysis-workflow\/ion-reporter-software.html?socid=social_btb\" target=\"_blank\">Ion Reporter\u2122 Software<\/a> to make their own discoveries from the trillions of bacterial cells and thousands of species that inhabit our bodies and the environment.<\/p>\n<p><iframe loading=\"lazy\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/N7tivSQb37k?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Early metagenomic work (before it was even called that) began in the early 1990\u2019s using a single PCR product that was cloned into a bacteriophage and then sequenced on a manual slab gel with radioactive 32P- labeled primers. Anyone remember those days? The field of metagenomics has been revolutionized by next-gen sequencing as researchers can<\/p>\n","protected":false},"author":115,"featured_media":7015,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[84],"tags":[103,11,6,74],"division":[],"class_list":{"0":"post-7095","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-metagenomics","8":"tag-16s-rrna-microbial","9":"tag-ion-torrent","10":"tag-next-generation-sequencing","11":"tag-sequencing","12":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Evolution of Metagenomic Sequencing - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/7095\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evolution of Metagenomic Sequencing\" \/>\n<meta property=\"og:description\" content=\"Early metagenomic work (before it was even called that) began in the early 1990\u2019s using a single PCR product that was cloned into a bacteriophage and then sequenced on a manual slab gel with radioactive 32P- labeled primers. Anyone remember those days? 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Today\u2019s labs are not only looking for accuracy\u2014they need speed, flexibility, and reliable\u2026","rel":"","context":"In &quot;General&quot;","block_context":{"text":"General","link":"https:\/\/admin.acceleratingscience.com\/behindthebench\/general\/"},"img":{"alt_text":"DNA sequencing sample tube with DNA helix and sequencing chromatogram representing Sanger sequencing workflow.","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2026\/08\/ChatGPT-Image-Aug-5-2026-09_44_12-AM.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":19883,"url":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/building-a-better-sample-qc-workflow-from-extraction-to-sequencing\/","url_meta":{"origin":7095,"position":1},"title":"Building a Better Sample QC Workflow: From Extraction to Sequencing","author":"Marlene Gasdia-Cochrane","date":"August 25, 2026","format":false,"excerpt":"Article Summary Successful genomics experiments don't begin with sequencing\u2014they begin with sample quality. 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