{"id":7700,"date":"2016-03-01T17:37:15","date_gmt":"2016-03-01T17:37:15","guid":{"rendered":"http:\/\/admin.acceleratingscience.com\/?p=7700"},"modified":"2020-05-28T19:10:28","modified_gmt":"2020-05-28T19:10:28","slug":"looking-at-tumor-evolution-with-cfdna","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/behindthebench\/looking-at-tumor-evolution-with-cfdna\/","title":{"rendered":"Liquid Biopsy Clinical Research \u2013 Looking at Tumor Evolution with cfDNA"},"content":{"rendered":"<p>Today, clinical researchers are using automated, end-to-end solutions to make the most of limited liquid biopsy samples. To enable this work, leaders in the field are partnering with us to design next-generation sequencing (NGS) assays that target critical questions in cancer research and tumor biology.<\/p>\n<p><strong><a href=\"http:\/\/www.i3s.up.pt\/research-groups\/cancer\/genetic-dynamics-cancer-cells\/person\/jose-luis-costa\" target=\"_blank\" rel=\"noopener noreferrer\">Professor Jos\u00e9 Luis Costa<\/a><\/strong>, PhD,\u00a0<span class=\"s1\">i3S\/IPATIMUP<\/span>, is leading efforts to use cell-free DNA (cfDNA) to detect rare mutations in lung cancer research blood samples. After his workshop at the Association of Molecular Pathology, we talked with him about the <u><a href=\"\/\/www.thermofisher.com\/us\/en\/home\/life-science\/cancer-research\/cancer-genomics\/liquid-biopsy-cancer-research-applications.html?CID=fl-WE120379?socid=social_btb\" target=\"_blank\" rel=\"noopener noreferrer\">liquid biopsy applications<\/a><\/u>.<\/p>\n<p><iframe loading=\"lazy\" width=\"760\" height=\"428\" src=\"https:\/\/www.youtube.com\/embed\/WR7wt2RZLM0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p><a href=\"http:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2016\/02\/costa-amp-2015-11-04-final-slide-for-blog1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-7850 size-medium\" src=\"http:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2016\/02\/costa-amp-2015-11-04-final-slide-for-blog1-300x225.jpg\" alt=\"Prof Jose Luis Costa\" width=\"300\" height=\"225\" srcset=\"https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2016\/02\/costa-amp-2015-11-04-final-slide-for-blog1-300x225.jpg 300w, https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2016\/02\/costa-amp-2015-11-04-final-slide-for-blog1-400x300.jpg 400w, https:\/\/admin.acceleratingscience.com\/behindthebench\/wp-content\/uploads\/sites\/9\/2016\/02\/costa-amp-2015-11-04-final-slide-for-blog1.jpg 720w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>His preliminary data (right) shows concordance in detection of somatic variants on cfDNA lung cancer\u00a0<span style=\"line-height: 1.5\">research\u00a0samples using the <\/span><a style=\"line-height: 1.5\" href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-select-targets\/ampliseq-target-selection.html?socid=social_btb\" target=\"_blank\" rel=\"noopener noreferrer\">Ion\u2122 AmpliSeq Colon and Lung Cancer Research Panel v2<\/a><span style=\"line-height: 1.5\"> and analyses on the <\/span><a style=\"line-height: 1.5\" href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/ion-torrent-next-generation-sequencing-workflow\/ion-torrent-next-generation-sequencing-run-sequence\/ion-pgm-system-for-next-generation-sequencing.html?socid=social_btb\" target=\"_blank\" rel=\"noopener noreferrer\">Ion\u2122 PGM System<\/a><span style=\"line-height: 1.5\"> and the Applied Biosystems\u2122 <\/span><a style=\"line-height: 1.5\" href=\"https:\/\/www.thermofisher.com\/us\/en\/home\/life-science\/pcr\/digital-pcr\/quantstudio-3d-digital-pcr-system.html?socid=social_btb\" target=\"_blank\" rel=\"noopener noreferrer\">QuantStudio\u2122 3D Digital PCR System<\/a><span style=\"line-height: 1.5\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>For more information on\u00a0<span class=\"s1\">Liquid biopsy solutions<\/span> and upcoming 2016 conferences <strong><a href=\"http:\/\/admin.acceleratingscience.com\/behindthebench\/ctcs-cfdna-and-germline-all-working-in-harmony\/?socid=social_btb\" target=\"_blank\" rel=\"noopener noreferrer\">click here<\/a><\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>For Research Use Only. Not for use in diagnostic procedures.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Today, clinical researchers are using automated, end-to-end solutions to make the most of limited liquid biopsy samples. To enable this work, leaders in the field are partnering with us to design next-generation sequencing (NGS) assays that target critical questions in cancer research and tumor biology. Professor Jos\u00e9 Luis Costa, PhD,\u00a0i3S\/IPATIMUP, is leading efforts to use<\/p>\n","protected":false},"author":120,"featured_media":7862,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[54],"tags":[17,11,43,55],"division":[],"class_list":{"0":"post-7700","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cancer-research","8":"tag-applied-biosystems","9":"tag-ion-torrent","10":"tag-pcr","11":"tag-peripheral-monitoring","12":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Liquid Biopsy Clinical Research \u2013 Looking at Tumor Evolution with cfDNA - Behind the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/looking-at-tumor-evolution-with-cfdna\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liquid Biopsy Clinical Research \u2013 Looking at Tumor Evolution with cfDNA\" \/>\n<meta property=\"og:description\" content=\"Today, clinical researchers are using automated, end-to-end solutions to make the most of limited liquid biopsy samples. 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